Explanipedia

G-Quadruplex Structures Formed by Human Telomere and C9orf72 GGGGCC Repeats Open

Bing Yan, Monica Ching Suen, Naining Xu, Chao Lu, Changdong Liu , et al. · 2025

G-quadruplexes (G4s) are unique nucleic acid structures composed of guanine-rich (G-rich) sequences that can form diverse topologies based on the arrangement of their four strands. G4s have attracted attention for their potential roles in …

Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD Open

Yanyan Geng, Changdong Liu, Naining Xu, Monica Ching Suen, Haitao Miao , et al. · 2024

The abnormal GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause the fatal neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal dementia. The transcribed RNA HREs, short for r(G4C2)n, can form t…

[Corrigendum] Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Open

Naining Xu, Honglei Tian, Chun Po Fung, Yuntao Lin, Yuling Chen , et al. · 2023

[This corrects the article DOI: 10.3892/etm.2023.11790.].

Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Open

Naining Xu, Honglei Tian, Chun Po Fung, Yuntao Lin, Yuling Chen , et al. · 2023

Head and neck squamous cell carcinoma (HNSCC), which originates from mucosal epithelium in the oral cavity, pharynx and larynx, is the sixth most common malignancy in the world. The prognosis of HNSCC is not satisfactory due to metastasis,…

CCDC 2082249: Experimental Crystal Structure Determination Open

Aifang Cheng, Changdong Liu, Wenkang Ye, Duli Huang, Weiyi She , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Selective <i>C9orf72</i> G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models Open

Aifang Cheng, Changdong Liu, Wenkang Ye, Duli Huang, Weiyi She , et al. · 2022

The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Developing selective G4-binding liga…

Cryo-EM structure of human hexameric MCM2-7 complex Open

Naining Xu, Qingpeng Lin, Honglei Tian, Changdong Liu, Peiyi Wang , et al. · 2022

The parallel tetrameric DNA G-quadruplex formed by the two-repeat C9orf72 GGGGCC sequence in solution Open

Changdong Liu, Bo Zhou, Naining Xu, Chun Po Fung, Bing Yan , et al. · 2022

LASER-ASSISTED HATCHING ON DAY 1 OF EMBRYO CULTURE DEMONSTRATES SIGNIFICANT IMPLANTATION RATE INCREASE COMPARED TO EMBRYOS WITH STANDARD DAY 3 ASSISTED HATCHING Open

Elizabeth A. Dilday, Nasario E. Ramos, Lindsay Kroener, Naining Xu, Nicholas Jackson , et al. · 2021

Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence Open

Yanyan Geng, Changdong Liu, Qixu Cai, Zhipu Luo, Haitao Miao , et al. · 2021

The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat exp…

Quantitative evaluation and comparison of two prodrug-activating suicide gene therapies on oral squamous cell carcinoma. Open

Naining Xu, Honglei Tian, Chun Po Fung, Yuntao Lin, Guang Zhu , et al. · 2021

Prodrug-activating suicide gene therapy (PA suicide gene therapy for short) for cancer is to introduce cancer cells with suicide genes. The enzyme encoded by suicide gene is not toxic but is able to kill cancer cells by converting a non-to…

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA Open

Naining Xu, Yingying You, Changdong Liu, Maxim Balasov, Lee Tung Lun , et al. · 2020

The six-subunit origin recognition complex (ORC), a DNA replication initiator, defines the localization of the origins of replication in eukaryotes. The Orc6 subunit is the smallest and the least conserved among ORC subunits. It is require…

The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA Open

Yanyan Geng, Changdong Liu, Bo Zhou, Qixu Cai, Haitao Miao , et al. · 2019

Human telomeric guanine-rich DNA, which could adopt different G-quadruplex structures, plays important roles in protecting the cell from recombination and degradation. Although many of these structures were determined, the chair-type G-qua…

Study on the existence of Environmental Kuznets Curve in China Open

Naining Xu · 2018

Environmental Kuznets Curve is one of the important indicators to measure environmental pollution and economic growth. This paper USES panel data of environment and economy of 31 provinces, municipalities and autonomous regions in China to…

A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K<sup>+</sup>solution Open

Changdong Liu, Bo Zhou, Yanyan Geng, Dick Yan Tam, Rui Feng , et al. · 2018

The chair-type G-quadruplex structure formed by human telomeric variant DNA.

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence Open

Bo Zhou, Yanyan Geng, Changdong Liu, Haitao Miao, Yaguang Ren , et al. · 2018

The large expansion of GGGGCC (G4C2) repeats of the C9orf72 gene have been found to lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The structural polymo…

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