Nairrita Majumder
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View article: Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury
Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury Open
No targeted interventions exist that improve the outcomes of patients with acute lung injury/ARDS. A few studies investigated Na + and Ca 2+ channels/transporters for potential therapeutic intervention but with limited translational succes…
View article: Pharmacological activation of BK channels protects against LPS-induced pneumonia
Pharmacological activation of BK channels protects against LPS-induced pneumonia Open
Bacterial pneumonia causes 1.4 million deaths annually worldwide. Besides antibiotics, current treatments are mostly supportive, and no other targeted therapies exist that improve patient outcomes. Key features of bacterial pneumonia inclu…
View article: Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone
Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone Open
Background Microbial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposure is scant. In thi…
View article: Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity
Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity Open
Air pollution accounts for more than 7 million premature deaths worldwide. Using ultrafine carbon black (CB) and ozone (O3) as a model for an environmental co-exposure scenario, the dose response relationships in acute pulmonary injury and…
View article: Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction
Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction Open
Background Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures. We examined transcriptomic changes after …
View article: Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure
Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Open
Environmental inhalation exposures are inherently mixed (gases and particles), yet regulations are still based on single toxicant exposures. While the impacts of individual components of environmental pollution have received substantial at…
View article: Ozone Inhalation During Sensitization Primes for a Greater Allergic Inflammation and Lung Function Decline
Ozone Inhalation During Sensitization Primes for a Greater Allergic Inflammation and Lung Function Decline Open
Asthma and other chronic obstructive pulmonary diseases are among the leading causes of respiratory morbidity and mortality.Episodes of increased air pollution precede significant increases in cardiopulmonary adverse event related hospital…
View article: Additional file 1 of Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction
Additional file 1 of Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction Open
Additional file 1. Raw data values used for generation of heat maps for real time PCR, ELISA, and primer sequences.
View article: Additional file 2 of Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction
Additional file 2 of Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction Open
Additional file 2. Differential expression analyses.