Naiyer Shahzad
YOU?
Author Swipe
View article: Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation
Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation Open
Introduction: Escitalopram oxalate (ESCI) is a biopharmaceutical classification system (BCS) class II antidepressant drug, that suffers limited oral bioavailability due to extensive hepatic metabolism. Therefore, this study aimed to develo…
View article: Karanjin-loaded soya lecithin-based ethosomal nanogel for the therapeutic intervention of psoriasis: formulation development, factorial design based-optimization, in vitro and in vivo assessment
Karanjin-loaded soya lecithin-based ethosomal nanogel for the therapeutic intervention of psoriasis: formulation development, factorial design based-optimization, in vitro and in vivo assessment Open
This study aimed to develop and optimize karanjin-loaded ethosomal nanogel formulation and evaluate its efficacy in alleviating symptoms of psoriasis in an animal model induced by imiquimod. These karanjin-loaded ethosomal nanogel, were fo…
View article: Glycemic homeostasis of ultrasound-assisted Murraya koenigii (Linn.) Spreng. bark extract in streptozocin-induced diabetes in rats
Glycemic homeostasis of ultrasound-assisted Murraya koenigii (Linn.) Spreng. bark extract in streptozocin-induced diabetes in rats Open
View article: A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer
A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer Open
View article: Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity
Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity Open
A novel combination of antibiotic, ciprofloxacin (CIP) with herbal counterpart naringin (NAR) was encapsulated by an oleic acid lipid core and carboxymethyl chitosan (CM-CS)/Alginate (AG) nanoparticle composite (CIP + NAR-CM-CS/AG-NPs) for…
View article: Synthesis and Characterization of Graphene Oxide/Polyethylene Glycol/Folic Acid/Brucine Nanocomposites and Their Anticancer Activity on HepG2 Cells
Synthesis and Characterization of Graphene Oxide/Polyethylene Glycol/Folic Acid/Brucine Nanocomposites and Their Anticancer Activity on HepG2 Cells Open
The results of this work demonstrate that GO/PEG/Bru-FA NCs suppress viability and induce apoptosis in HepG2 cells, indicating their potential as an anticancer candidate.
View article: Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR
Genetic Analysis and Epidemiological Impact of SARS-CoV-2: A Multinational Study of 1000 Samples Using RT-PCR Open
The ongoing global public health challenge posed by the COVID-19 pandemic necessitates continuous research and surveillance efforts. In this study, we comprehensively analyzed over 1000 COVID-19 RT-PCR tests conducted on a cohort of 1200 p…
View article: A cross-sectional study comparing the use of e-cigarettes and traditional tobacco cigarettes among young Makkah people
A cross-sectional study comparing the use of e-cigarettes and traditional tobacco cigarettes among young Makkah people Open
Background and Aims: Tobacco smoking has a significant role in health deterioration worldwide. The study was conducted to estimate the prevalence and awareness of smoking among young Makkah people. Methods: A cross-sectional study was cond…
View article: Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review
Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review Open
View article: Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells
Graphene oxide/chitosan/manganese/folic acid-brucine functionalized nanocomposites show anticancer activity against liver cancer cells Open
Nanomedicine is the application of nanomaterials and nanotechnology to the development of novel pharmaceuticals and drug delivery mechanisms. The present study synthesized a functionalized nanocomposite (NC) containing graphene oxide (GO),…
View article: The Gastroprotective Effects of Hydroalcoholic Extract of Monolluma quadrangula against Ethanol-Induced Gastric Mucosal Injuries in Sprague Dawley Rats [Retraction]
The Gastroprotective Effects of Hydroalcoholic Extract of Monolluma quadrangula against Ethanol-Induced Gastric Mucosal Injuries in Sprague Dawley Rats [Retraction] Open
[This retracts the article DOI: 10.2147/DDDT.S91247.].
View article: The Efficacy of Manual Therapy and Pressure Biofeedback-Guided Deep Cervical Flexor Muscle Strength Training on Pain and Functional Limitations in Individuals with Cervicogenic Headaches: A Randomized Comparative Study
The Efficacy of Manual Therapy and Pressure Biofeedback-Guided Deep Cervical Flexor Muscle Strength Training on Pain and Functional Limitations in Individuals with Cervicogenic Headaches: A Randomized Comparative Study Open
Objective. This study aimed to compare the efficacy of manual therapy and pressure biofeedback-guided DCFM strength training on pain intensity and functional limitations in individuals with CGH. Trial Design. A double-blinded, two-arm para…
View article: COVID-19 and severity of liver diseases: Possible crosstalk and clinical implications
COVID-19 and severity of liver diseases: Possible crosstalk and clinical implications Open
COVID-19-infected individuals and those who recovered from the infection have been demonstrated to have elevated liver enzymes or abnormal liver biochemistries, particularly with preexisting liver diseases, liver metabolic disorders, viral…
View article: Monitoring of adverse drug reactions in individuals with type 2 diabetes mellitus receiving oral hypoglycemic agents
Monitoring of adverse drug reactions in individuals with type 2 diabetes mellitus receiving oral hypoglycemic agents Open
Background: This study intends to ascertain the prevalence and overall burden of various adverse drug reactions (ADRs) driven by oral antidiabetics for treating type II diabetes mellitus (T2DM) in India. Methods: Patients with T2DM taking …
View article: The Role of Selective Flavonoids on Triple-Negative Breast Cancer: An Update
The Role of Selective Flavonoids on Triple-Negative Breast Cancer: An Update Open
Among the many types of breast cancer (BC), Triple-Negative Breast Cancer (TNBC) is the most alarming. It lacks receptors for the three main biomarkers: estrogen, progesterone, and human epidermal growth factor, hence the name TNBC. This m…
View article: Phytochemical D-Pinitol Loaded Graphene Oxide-Chitosan-Folic Acid Nanocomposite Induced Apoptosis in Hepatoma Hepg-2 Cells
Phytochemical D-Pinitol Loaded Graphene Oxide-Chitosan-Folic Acid Nanocomposite Induced Apoptosis in Hepatoma Hepg-2 Cells Open
View article: A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer
A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer Open
β–sitosterol is the most abundant type of phytosterol or plant sterol and can be found in various plant dietary sources including natural oils, soy products, and nuts. Numerous studies have demonstrated the potential therapeutic and clinic…
View article: Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review
Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review Open
Methods: This review provides scientific grounds in the literature for the phytochemical and pharmacological activities of Rhododendron arboreum, from 2010- 2021. Chiefly three bibliographic databases were used as the main sources of infor…
View article: Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry
Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry Open
View article: Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells
Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells Open
This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, po…
View article: In Vivo Pharmacological Testing of Herbal Drugs for Anti-Allergic and Anti-Asthmatic Properties
In Vivo Pharmacological Testing of Herbal Drugs for Anti-Allergic and Anti-Asthmatic Properties Open
Background: Asthma is a chronic inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness, and remodeling. Asthma prevalence has increased significantly globally over the last decade, and it remains incurable…
View article: Olea europaea subsp. Cuspidata and Juniperus procera Hydroalcoholic Leaves' Extracts Modulate Stress Hormones in Stress-Induced Cystitis in Rats
Olea europaea subsp. Cuspidata and Juniperus procera Hydroalcoholic Leaves' Extracts Modulate Stress Hormones in Stress-Induced Cystitis in Rats Open
Objective: To study the effect of Saudi medicinal plant in stress-induced cystitis in experimental rats. Materials and Methods: Seventy-two female Sprague Dawley rats (200–250 g) were divided into eight groups of 9 rats each. Group 1 and 2…
View article: Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells
Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells Open
View article: The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats
The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats Open
Evidence shows that inflammatory and immune processes within the brain might account for the pathophysiology of epilepsy. Therefore, developing new antiepileptic drugs that can modulate seizures through mechanisms other than traditional dr…
View article: The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats
The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats Open
Monolluma quadrangula (Forssk.) Plowes is used in Saudi traditional medicines to treat gastric ulcers. The hydroalcoholic extract of M. quadrangula (MHAE) was used in an in vivo model to investigate its gastroprotective effects against eth…