Nam Yong Lee
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View article: Species distribution of nontuberculous mycobacteria isolated from respiratory specimens at a tertiary care hospital in South Korea, 2017–2022
Species distribution of nontuberculous mycobacteria isolated from respiratory specimens at a tertiary care hospital in South Korea, 2017–2022 Open
The clinical relevance and drug resistance patterns of nontuberculous mycobacteria (NTM) vary by species. This study investigated the species distribution of NTM isolated from respiratory specimens at a tertiary care hospital in South Kore…
View article: Prospective Comparative Evaluation of the Xpert MTB/RIF and Xpert MTB/RIF Ultra Assays for Detecting <i>Mycobacterium tuberculosis</i> and Rifampin Resistance in High-resource, Intermediate-burden Settings
Prospective Comparative Evaluation of the Xpert MTB/RIF and Xpert MTB/RIF Ultra Assays for Detecting <i>Mycobacterium tuberculosis</i> and Rifampin Resistance in High-resource, Intermediate-burden Settings Open
Xpert Ultra tends to have increased sensitivity; however, it shows potential diagnostic ambiguity associated with trace- or very low-positive results. These findings highlight the importance of clinical correlation, particularly in culture…
View article: Evaluation of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor combinations and colistin in carbapenem-non-susceptible gram-negative bacilli
Evaluation of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor combinations and colistin in carbapenem-non-susceptible gram-negative bacilli Open
We assessed the performance of the VITEK 2 AST-N439 card for susceptibility testing of novel β-lactam/β-lactamase inhibitor (BL/BLI) combinations and colistin in carbapenem-non-susceptible gram-negative isolates. A total of 425 clinical is…
View article: Experimental study on factors influencing low identification rates and spectral quality of <i>Streptococcus pneumoniae</i> using the Sepsityper kit
Experimental study on factors influencing low identification rates and spectral quality of <i>Streptococcus pneumoniae</i> using the Sepsityper kit Open
The MBT Sepsityper Kit (Sepsityper) has a low identification rate for Streptococcus pneumoniae , and the underlying causes remain unclear. To elucidate these factors, we investigated five factors under controlled conditions simulating bloo…
View article: Evaluation of the cobas SARS-CoV-2 & Influenza A/B v2 assay for detecting SARS-CoV-2 and influenza A and B viruses in nasopharyngeal swab specimens
Evaluation of the cobas SARS-CoV-2 & Influenza A/B v2 assay for detecting SARS-CoV-2 and influenza A and B viruses in nasopharyngeal swab specimens Open
Accurate and rapid diagnostic assays that simultaneously detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/B are crucial for effective clinical management and infection control. In the present study, we ev…
View article: Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection
Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection Open
Microbiological diagnosis of pleural infection is often hindered by the low sensitivity of conventional culture. The automated blood culture system (ABCS) has been shown to improve diagnostic sensitivity for the culture of non-blood specim…
View article: Environmental Mold Management in Negative‐Pressure Isolation Wards During the COVID‐19 Pandemic: A Potential Indicator of COVID‐19‐Associated Pulmonary Aspergillosis
Environmental Mold Management in Negative‐Pressure Isolation Wards During the COVID‐19 Pandemic: A Potential Indicator of COVID‐19‐Associated Pulmonary Aspergillosis Open
High concentration of mold spores in inhaled air is an important risk factor for invasive mold infections. COVID‐19 (coronavirus disease 2019)‐associated pulmonary aspergillosis (CAPA) is a serious complication of severe COVID‐19. To inves…
View article: Comparison of the STANDARD M10 <i>C</i> . <i>difficile</i> , Xpert <i>C</i> . <i>difficile</i> , and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing <i>Clostridioides difficile</i> infection
Comparison of the STANDARD M10 <i>C</i> . <i>difficile</i> , Xpert <i>C</i> . <i>difficile</i> , and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing <i>Clostridioides difficile</i> infection Open
Current guidelines recommend a two-step algorithm rather than relying solely on a single test for diagnosing Clostridioides difficile infection. This algorithm starts with enzyme immunoassay (EIA) for detecting glutamate dehydrogenase (GDH…
View article: Group B <i>Streptococcus</i> Detection Rate and Clindamycin Resistance Among Reproductive-Age Women in Korea During 2003–2022
Group B <i>Streptococcus</i> Detection Rate and Clindamycin Resistance Among Reproductive-Age Women in Korea During 2003–2022 Open
This study demonstrated that GBS detection rates in Korean women of reproductive age significantly increased almost three times during the twenty years of the study period, with a persistently high clindamycin resistance rate of up to 40%.
View article: Comparative evaluation of the STANDARD M10 and Xpert <i>C</i> . <i>difficile</i> assays for detection of toxigenic <i>Clostridioides difficile</i> in stool specimens
Comparative evaluation of the STANDARD M10 and Xpert <i>C</i> . <i>difficile</i> assays for detection of toxigenic <i>Clostridioides difficile</i> in stool specimens Open
This study compared the performance of two commercial molecular assays, the STANDARD M10 Clostridioides difficile assay (M10) and the Xpert C. difficile assay (Xpert), for detecting toxigenic C. difficile in stool specimens. A total of 487…
View article: Evaluation of the <scp>QMAC‐</scp>d<scp>RAST</scp> System Version 2.5 for Rapid Antimicrobial Susceptibility Testing of Gram‐Negative Bacteria From Positive Blood Culture Broth and Subcultured Colony Isolates
Evaluation of the <span>QMAC‐</span>d<span>RAST</span> System Version 2.5 for Rapid Antimicrobial Susceptibility Testing of Gram‐Negative Bacteria From Positive Blood Culture Broth and Subcultured Colony Isolates Open
Background Rapid antimicrobial susceptibility testing (AST) for bloodstream infections (BSIs) facilitates the optimization of antimicrobial therapy, preventing antimicrobial resistance and improving patient outcomes. QMAC‐dRAST (QuantaMatr…
View article: Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam
Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam Open
With the introduction of ceftazidime-avibactam worldwide, the antimicrobial activity of new β-lactam/β-lactamase inhibitors (BL/BLIs) needs to be investigated. From January 2020 to June 2023, Klebsiella pneumoniae carbapenemase (KPC)-produ…
View article: Performance evaluation of the SMG HHV-6 Q Real-Time PCR Kit for quantitative detection and differentiation of human herpesvirus 6A and 6B
Performance evaluation of the SMG HHV-6 Q Real-Time PCR Kit for quantitative detection and differentiation of human herpesvirus 6A and 6B Open
The aim of this study was to compare the performance of the newly developed SMG HHV-6 Q Real-Time PCR Kit (SMG assay) with the RealStar HHV-6 PCR Kit (RealStar assay). The analytical sensitivity and specificity, linearity, and precision of…
View article: Rab14 Mediates Mitochondrial Dynamics and Mitophagy
Rab14 Mediates Mitochondrial Dynamics and Mitophagy Open
View article: No Significant Differences in Presepsin Levels According to the Causative Microorganism of Bloodstream Infection
No Significant Differences in Presepsin Levels According to the Causative Microorganism of Bloodstream Infection Open
We demonstrated that there were no significant differences in plasma presepsin levels according to microbial isolates in blood culture. The major cause of the variability in presepsin levels during bloodstream infection might be the immuno…
View article: 1106. Comparison of Diagnostic Power of Conventional Culture and Automated Blood Culture System with Pleural Fluid
1106. Comparison of Diagnostic Power of Conventional Culture and Automated Blood Culture System with Pleural Fluid Open
Background Microbiological diagnosis of empyema is often hindered by low sensitivity of conventional culture. Automated blood culture system has been reported to enhance diagnostic power for culture of non-blood specimens. The purpose of t…
View article: 212. Effectiveness of Empirical Piperacillin/tazobactam Compared to Cefepime for Bloodstream Infection Caused by Gram-Negative Bacilli
212. Effectiveness of Empirical Piperacillin/tazobactam Compared to Cefepime for Bloodstream Infection Caused by Gram-Negative Bacilli Open
Background Piperacillin/tazobactam (PTZ) and cefepime (CFP) are commonly used antibiotics for healthcare-associated infections and immunocompromised patients. However, few studies have compared the clinical effectiveness of these two antib…
View article: Optimization of extraction-free protocols for SARS-CoV-2 detection using a commercial rRT-PCR assay
Optimization of extraction-free protocols for SARS-CoV-2 detection using a commercial rRT-PCR assay Open
In the ongoing global fight against coronavirus disease 2019 (COVID-19), the sample preparation process for real-time reverse transcription polymerase chain reaction (rRT-PCR) faces challenges due to time-consuming steps, labor-intensive p…
View article: Evaluation of a Modified Protocol for the SepsiPrep Kit for Direct Identification and Antimicrobial Susceptibility Testing From Positive Blood Culture Using BACTEC Plus and BacT/Alert Blood Culture Bottles
Evaluation of a Modified Protocol for the SepsiPrep Kit for Direct Identification and Antimicrobial Susceptibility Testing From Positive Blood Culture Using BACTEC Plus and BacT/Alert Blood Culture Bottles Open
View article: False-positive <i>Aspergillus</i> galactomannan immunoassay in the glucose component of total parenteral nutrition products
False-positive <i>Aspergillus</i> galactomannan immunoassay in the glucose component of total parenteral nutrition products Open
In October 2022, we experienced a significant increase in samples showing high galactomannan (GM) indexes ranging from 6.22 to 10.58, as determined by the Platelia Aspergillus antigen immunoassay, also known as the GM test. After reviewing…
View article: Optimization of Extraction-Free Protocols for SARS-CoV-2 Detection using a Commercial rRT-PCR Assay
Optimization of Extraction-Free Protocols for SARS-CoV-2 Detection using a Commercial rRT-PCR Assay Open
The global combat against coronavirus disease 2019 (COVID-19) has primarily focused on developing innovative nucleic acid-based molecular diagnostic techniques and streamlining associated protocols. In this study, we investigated extractio…
View article: The lung microbiota in nontuberculous mycobacterial pulmonary disease
The lung microbiota in nontuberculous mycobacterial pulmonary disease Open
Background The role of bacterial microbiota in the pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM-PD) is unclear. We aimed to compare the bacterial microbiome of disease-invaded lesions and non-invaded lung tissue from…
View article: Impact of vancomycin resistance in Enterococcus faecium bloodstream infection on mortality: A retrospective analysis of nationwide surveillance data
Impact of vancomycin resistance in Enterococcus faecium bloodstream infection on mortality: A retrospective analysis of nationwide surveillance data Open
In patients with Efm BSI, vancomycin resistance was independently associated with mortality.
View article: Review of: "Characterizing the Initial and Subsequent NFT Sales Market Dynamics: Perspectives from Boom and Slump Periods"
Review of: "Characterizing the Initial and Subsequent NFT Sales Market Dynamics: Perspectives from Boom and Slump Periods" Open
My view point on NFT is highly skeptical, not much different from Bill Gates' viewpoint; NFTs are ’100% based on greater fool theory’. Based on this viewpoint, the results found in the manuscript are fairly predictable.
View article: Reducing Microbial Contamination in Hematopoietic Stem Cell Products and Quality Improvement Strategy: Retrospective Analysis of 1996-2021 Data
Reducing Microbial Contamination in Hematopoietic Stem Cell Products and Quality Improvement Strategy: Retrospective Analysis of 1996-2021 Data Open
The contamination rate decreased significantly during period 2, when the HSC management system was reorganized. Our results imply that handling HSC products by trained personnel and adopting established protocols, including quality assuran…
View article: Evaluation of the AdvanSure One-Stop COVID-19 Plus Kit for SARS-CoV-2 Detection Using a Streamlined RNA Extraction Method
Evaluation of the AdvanSure One-Stop COVID-19 Plus Kit for SARS-CoV-2 Detection Using a Streamlined RNA Extraction Method Open
Real-time reverse transcription (rRT)-PCR, which is the reference standard for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, generally involves a time-consuming and costly RNA extraction step prio…
View article: Retraction for Shin et al., “ <i>bla</i> <sub>NDM-5</sub> -Bearing IncFII-Type Plasmids of Klebsiella pneumoniae Sequence Type 147 Transmitted by Cross-Border Transfer of a Patient”
Retraction for Shin et al., “ <i>bla</i> <sub>NDM-5</sub> -Bearing IncFII-Type Plasmids of Klebsiella pneumoniae Sequence Type 147 Transmitted by Cross-Border Transfer of a Patient” Open
Volume 60, no. 3, p. 1932–1934, 2016, https://doi.org/10.1128/aac.02722-15. We hereby retract this article published in Antimicrobial Agents and Chemotherapy because of the presence of some errors in sequencing analysis for the published p…
View article: Performance Evaluation of the BACTEC MGIT 960 System for Rifampin Drug-Susceptibility Testing of Mycobacterium tuberculosis Using the Current WHO Critical Concentration
Performance Evaluation of the BACTEC MGIT 960 System for Rifampin Drug-Susceptibility Testing of Mycobacterium tuberculosis Using the Current WHO Critical Concentration Open
The World Health Organization recently lowered the rifampin (RIF) critical concentration (CC) for drug-susceptibility testing (DST) of Mycobacterium tuberculosis complex (MTBC) using the mycobacterial growth indicator tube (MGIT) 960 syste…
View article: Severe Human Rhinovirus Lower Respiratory Tract Infections in Young Children
Severe Human Rhinovirus Lower Respiratory Tract Infections in Young Children Open
View article: Evaluation of the Kaira COVID-19/Flu/RSV Detection Kit for detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus: A comparative study with the PowerChek SARS-CoV-2, influenza A&B, RSV Multiplex Real-time PCR Kit
Evaluation of the Kaira COVID-19/Flu/RSV Detection Kit for detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus: A comparative study with the PowerChek SARS-CoV-2, influenza A&B, RSV Multiplex Real-time PCR Kit Open
Background Co-circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses, such as influenza and respiratory syncytial virus (RSV), can be a severe threat to public health. The accurate detecti…