Namit Ranjan
YOU?
Author Swipe
View article: Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2
Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2 Open
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthami…
View article: Modulation of translational decoding by m6A modification of mRNA
Modulation of translational decoding by m6A modification of mRNA Open
N 6 -methyladenosine (m 6 A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m 6 A in the mRNA coding regions inhibits translation elongation. Here, we show how m 6 A modulates decoding in th…
View article: Translation Phases in Eukaryotes
Translation Phases in Eukaryotes Open
Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and ribosome recycling. In this review, we pro…
View article: Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation
Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation Open
In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the ribosomal A and E sites, its exact mecha…
View article: Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast Open
The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins, containing a single C-terminal transmembrane domain, to the ER. Here we uncover how the yeast GET pathway compone…
View article: eEF3 promotes late stages of tRNA translocation on the ribosome
eEF3 promotes late stages of tRNA translocation on the ribosome Open
Summary In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the A and E sites, its exact mechani…
View article: The epitranscriptome in translation regulation: <scp>mRNA</scp> and <scp>tRNA</scp> modifications as the two sides of the same coin?
The epitranscriptome in translation regulation: <span>mRNA</span> and <span>tRNA</span> modifications as the two sides of the same coin? Open
Translation of mRNA is a highly regulated process that is tightly coordinated with cotranslational protein maturation. Recently, mRNA modifications and tRNA modifications – the so called epitranscriptome – have added a new layer of regulat…
View article: tRNA wobble modifications and protein homeostasis
tRNA wobble modifications and protein homeostasis Open
tRNA is a central component of the protein synthesis machinery in the cell. In living cells, tRNAs undergo numerous post-transcriptional modifications. In particular, modifications at the anticodon loop play an important role in ensuring e…