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View article: Understanding human mobility patterns under a public health emergency
Understanding human mobility patterns under a public health emergency Open
These findings highlight the importance of integrating different mobility models to capture the complex human mobility picture by different population groups during an epidemic outbreak. Overall, this study advances our understanding of be…
View article: Tailoring hierarchical deformation mechanisms in metastable β titanium alloy via heterogeneous lamellar β structure design
Tailoring hierarchical deformation mechanisms in metastable β titanium alloy via heterogeneous lamellar β structure design Open
The deformation mechanism of Ti-7Mo-3Nb-3Cr-3Al alloy was tailored by constructing heterogeneous lamellar β structure. This structural design induces hierarchical mechanism and thereby enhances work hardening and ultimate strength. During …
View article: YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs
YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs Open
Despite promising initial results in targeting the RAF-MEK-ERK cascade, resistance to BRAF/MEK inhibitors remains a critical challenge in nearly 50% of melanoma patients. Our study demonstrates that robust YAP1 activation in metastatic mel…
View article: Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis
Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis Open
View article: Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study
Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study Open
Background The seasonal cycle of the influenza virus causes substantial morbidity and mortality globally. The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the circulation of influenza viruses can influence infl…
View article: The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction
The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction Open
Manganese-based STING-activating tumor immunotherapy faces limitations due to T cell exhaustion. Mitochondrial dysfunction is a key factor contributing to T cell exhaustion. Modulating mitochondrial function during manganese-based immunoth…
View article: Interface‐Directed Growth of Tin Perovskite for Efficient Light‐Emitting Diodes
Interface‐Directed Growth of Tin Perovskite for Efficient Light‐Emitting Diodes Open
Controlling the crystallization dynamics of solution‐processed tin perovskites remains pivotal yet challenging for achieving high‐performance lead‐free optoelectronic devices. Herein, it is demonstrated that substrate‐regulated interfacial…
View article: 3'-Sialyllactose and <i>B. infantis</i> synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis
3'-Sialyllactose and <i>B. infantis</i> synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis Open
Ulcerative colitis (UC) poses significant threats to human health and quality of life worldwide, as it is a chronic inflammatory bowel disease. 3'-sialyllactose (3'-SL) is a key functional component of milk oligosaccharides. This study sys…
View article: Multidimensional regulation of transcription factors: decoding the comprehensive signals of plant secondary metabolism
Multidimensional regulation of transcription factors: decoding the comprehensive signals of plant secondary metabolism Open
Plants synthesize an extensive array of secondary metabolites in response to diverse biotic and abiotic stresses. These metabolites function not only as defensive compounds but also constitute significant sources of nutrition and pharmaceu…
View article: Hyperwilsol a, a Highly Modified 2-Nor-Polycyclic Polyprenylated Acylphloroglucinol Possessing an Unusual 6/6/5/5 Spirotetracyclic Skeleton from Hypericum Wilsonii
Hyperwilsol a, a Highly Modified 2-Nor-Polycyclic Polyprenylated Acylphloroglucinol Possessing an Unusual 6/6/5/5 Spirotetracyclic Skeleton from Hypericum Wilsonii Open
View article: Recognition site modifiable tetrapodal receptor and the effect of alkane chains on monosaccharide recognition
Recognition site modifiable tetrapodal receptor and the effect of alkane chains on monosaccharide recognition Open
Traditional molecular recognition studies usually focus on obtaining strong host–guest interactions, which may lead to the neglect of important tendencies caused by other factors. Moreover, most receptors typically fix their recognition si…
View article: Dynamic Path-Planning Approach of Garbage Cleanup Oriented Unmanned Ship Based on Simplified Flow Velocity Prediction
Dynamic Path-Planning Approach of Garbage Cleanup Oriented Unmanned Ship Based on Simplified Flow Velocity Prediction Open
Research on artificial intelligence and robotics for the ecological protection and restoration of waters has increased in importance with the promotion of national green sustainable development strategies. Autonomous Surface Vessel for Wat…
View article: AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis Open
View article: Developments and prospects of multiple cropping in China
Developments and prospects of multiple cropping in China Open
China is the country with the most extensive development of multiple cropping worldwide with a long history. Multiple cropping plays an irreplaceable role in alleviating the contradiction between more people and less land, ensuring nationa…
View article: OsUGE2 Regulates Plant Growth through Affecting ROS Homeostasis and Iron Level in Rice
OsUGE2 Regulates Plant Growth through Affecting ROS Homeostasis and Iron Level in Rice Open
View article: Differential Microbial Degradation of Cross-Linked Polythene by Aspergillus Niger in Space and on the Ground
Differential Microbial Degradation of Cross-Linked Polythene by Aspergillus Niger in Space and on the Ground Open
View article: Underactuated Humanoid Peeling Approach for Pickled Mustard Tuber Based on Metamorphic Constraints
Underactuated Humanoid Peeling Approach for Pickled Mustard Tuber Based on Metamorphic Constraints Open
Pickled mustard tuber (PMT), also known as Brassica juncea var. tumida, is a conical tuberous vegetable with a scaly upper part and a coarse fiber skin covering the lower part. Due to its highly distorted and complex heterogeneous fiber ne…
View article: Breastmilk microbiome changes associated with lactational mastitis and treatment with dandelion extract
Breastmilk microbiome changes associated with lactational mastitis and treatment with dandelion extract Open
Introduction Dandelion (Pugongying) is one of the most frequently used Chinese herbs for treating lactational mastitis (LM). Pugongying granules, a patented medication primarily comprised of dandelion extract, have been approved by CFDA fo…
View article: Construction of an index system of the biosafety incident response capability for nursing staff: A Delphi study
Construction of an index system of the biosafety incident response capability for nursing staff: A Delphi study Open
Aim: This study was to establish an index system of the biosafety incident response capability for nursing staff. Background: Faced with austere situations of the biosafety threat, the study on the requirement for nursing staff to respond …
View article: Construction and application on the training course of information literacy for clinical nurses
Construction and application on the training course of information literacy for clinical nurses Open
Design A two-round Delphi survey was conducted to seek opinions from experts about the index system for the evaluation of training courses of clinical nursing staff’s information literacy. Besides, a non-randomized controlled experimental …
View article: Nuclear translocation of OsMADS25 facilitated by OsNAR2.1 in reponse to nitrate signals promotes rice root growth by targeting OsMADS27 and OsARF7
Nuclear translocation of OsMADS25 facilitated by OsNAR2.1 in reponse to nitrate signals promotes rice root growth by targeting OsMADS27 and OsARF7 Open
Nitrate is an important nitrogen source and signaling molecule that regulates plant growth and development. Although several components of the nitrate signaling pathway have been identified, the detailed mechanisms are still unclear. Our p…
View article: Psychological capital and alienation among patients with COVID-19 infection: the mediating role of social support
Psychological capital and alienation among patients with COVID-19 infection: the mediating role of social support Open
Background COVID-19 infection continues all over the world, causing serious physical and psychological impacts to patients. Patients with COVID-19 infection suffer from various negative emotional experiences such as anxiety, depression, ma…
View article: Practice and consideration of master protocol in clinical trials
Practice and consideration of master protocol in clinical trials Open
There is considerable interest in expediting late-stage therapy development by efficiently conducting trial designs that encompass multiple therapies or multiple subpopulations simultaneously within a unified protocol. Such trial designs a…
View article: Protocol for Bulk-ATAC sequencing in head and neck squamous cell carcinoma
Protocol for Bulk-ATAC sequencing in head and neck squamous cell carcinoma Open
View article: The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis
The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis Open
View article: Systematic analysis of MADS-box gene family in the U’s triangle species and targeted mutagenesis of BnaAG homologs to explore its role in floral organ identity in Brassica napus
Systematic analysis of MADS-box gene family in the U’s triangle species and targeted mutagenesis of BnaAG homologs to explore its role in floral organ identity in Brassica napus Open
MADS-box transcription factors play an important role in regulating floral organ development and participate in environmental responses. To date, the MADS-box gene family has been widely identified in Brassica rapa ( B. rapa ), Brassica ol…
View article: Psychological Capital and Alienation among patients with COVID-19 infection: The mediating role of Social Support
Psychological Capital and Alienation among patients with COVID-19 infection: The mediating role of Social Support Open
Background COVID-19 infection continues all over the world, causing serious physical and psychological impacts to patients. Patients with COVID-19 infection suffer from various negative emotional experiences such as anxiety, depression, ma…
View article: The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis
The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis Open
Background: The fear of hypoglycemia in type 2 diabetes mellitus (T2DM) patients with hypoglycemia has seriously affected their quality of life. They are always afraid of hypoglycemia and often take excessive action to avoid it. Yet, resea…
View article: The regulatory role of BMP4 in testicular Sertoli cells of Tibetan sheep
The regulatory role of BMP4 in testicular Sertoli cells of Tibetan sheep Open
This study aimed to determine the regulatory mechanism of bone morphogenetic protein 4 (BMP4) gene in the testes of Tibetan sheep and its role in the blood–testis barrier (BTB). First, we cloned BMP4 gene for bioinformatics analysis, and d…
View article: Trilobatin attenuates blood-brain barrier dysfunction induced by cerebral ischemia reperfusion by targeting MMP9: Involvement of APOE4/CypA/NF-κB signaling
Trilobatin attenuates blood-brain barrier dysfunction induced by cerebral ischemia reperfusion by targeting MMP9: Involvement of APOE4/CypA/NF-κB signaling Open
Background and Purpose: Blood-brain barrier (BBB) breakdown is one of the most crucial pathological changes of cerebral ischemia-reperfusion (I/R) injury. Trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect…