Nanami Senoo
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View article: Disturbed mitochondrial maturation in cardiolipin remodeling-deficient cardiomyocytes
Disturbed mitochondrial maturation in cardiolipin remodeling-deficient cardiomyocytes Open
Summary Barth syndrome, a rare X-linked genetic disorder, features early-onset cardiomyopathy. The causal gene, TAFAZZIN , encodes a transacylase that mediates acyl chain remodeling of cardiolipin, a critical phospholipid in the inner mito…
View article: Mitochondrial Structure and Function in Human Heart Failure
Mitochondrial Structure and Function in Human Heart Failure Open
Despite clinical and scientific advancements, heart failure is the major cause of morbidity and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the development and progression of heart failure. Although i…
View article: Abstract 1951 Conserved and specific cardiolipin-mitochondrial ADP/ATP carrier interactions assume structural and functional roles
Abstract 1951 Conserved and specific cardiolipin-mitochondrial ADP/ATP carrier interactions assume structural and functional roles Open
Lipid-protein interactions are crucial for maintaining membrane homeostasis. Mitochondrial membranes have a unique lipid-protein environment that ensures bioenergetic efficiency. Cardiolipin, the signature phospholipid in mitochondria, pla…
View article: Abstract 1376 LPLAT7 regulates acyl chain profiles at sn-1 position of phospholipids in murine skeletal muscle
Abstract 1376 LPLAT7 regulates acyl chain profiles at sn-1 position of phospholipids in murine skeletal muscle Open
Skeletal muscle consists of both fast- and slow-twitch fibers. Phospholipids (PLs) are essential structural components of cellular membranes, and the diversity of their fatty acid compositions affects membrane fluidity and permeability. Al…
View article: Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice
Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice Open
Low-temperature-induced fatty acid desaturation is highly conserved in animals, plants, and bacteria. Allyl isothiocyanate (AITC) is an agonist of the transient receptor potential ankyrin 1 (TRPA1), which is activated by various chemophysi…
View article: APOE expression and secretion are modulated by mitochondrial dysfunction
APOE expression and secretion are modulated by mitochondrial dysfunction Open
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more ex…
View article: Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant Open
Summary The mitochondrial phospholipid cardiolipin (CL) promotes bioenergetics via oxidative phosphorylation (OXPHOS). Three tightly bound CLs are evolutionarily conserved in the ADP/ATP carrier (AAC in yeast; adenine nucleotide translocat…
View article: Author response: APOE expression and secretion are modulated by mitochondrial dysfunction
Author response: APOE expression and secretion are modulated by mitochondrial dysfunction Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mitocho…
View article: APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction
APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction Open
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more ex…
View article: Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry
Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry Open
A complex interplay between the extracellular space, cytoplasm and individual organelles modulates Ca2+ signaling to impact all aspects of cell fate and function. In recent years, the molecular machinery linking endoplasmic reticulum store…
View article: Fasting increases 18:2-containing phosphatidylcholines to complement the decrease in 22:6-containing phosphatidylcholines in mouse skeletal muscle
Fasting increases 18:2-containing phosphatidylcholines to complement the decrease in 22:6-containing phosphatidylcholines in mouse skeletal muscle Open
Fasting stimulates catabolic reactions in skeletal muscle to survive nutrient deprivation. Cellular phospholipids have large structural diversity due to various polar-heads and acyl-chains that affect many cellular functions. Skeletal musc…
View article: Cardiolipin, conformation, and respiratory complex-dependent oligomerization of the major mitochondrial ADP/ATP carrier in yeast
Cardiolipin, conformation, and respiratory complex-dependent oligomerization of the major mitochondrial ADP/ATP carrier in yeast Open
The structural assembly and conformation of yeast’s major ADP/ATP carrier is dependent on the signature lipid of mitochondria.
View article: Phospholipid ebb and flow makes mitochondria go
Phospholipid ebb and flow makes mitochondria go Open
Mitochondria, so much more than just being energy factories, also have the capacity to synthesize macromolecules including phospholipids, particularly cardiolipin (CL) and phosphatidylethanolamine (PE). Phospholipids are vital constituents…
View article: Metabolomic Analysis of Skeletal Muscle in Aged Mice
Metabolomic Analysis of Skeletal Muscle in Aged Mice Open
Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function. To better understand changes in skeletal muscle during sarcopenia, we performed a metabolomic analysis of skeletal muscle in young (8-week-old) and aged …
View article: Improved skeletal muscle Ca<sup>2+</sup> regulation in vivo following contractions in mice overexpressing PGC-1α
Improved skeletal muscle Ca<sup>2+</sup> regulation in vivo following contractions in mice overexpressing PGC-1α Open
In skeletal muscle, resting intracellular Ca 2+ concentration ([Ca 2+ ] i ) homeostasis is exquisitely regulated by Ca 2+ transport across the sarcolemmal, mitochondrial, and sarcoplasmic reticulum (SR) membranes. Of these three systems, t…
View article: Sports medicine and diseases
Sports medicine and diseases Open
The differences in regional distribution of white adipose tissue (WAT) has been related to both cardiovascular and diabetes risk profile.Recently, the homeobox superfamily is attracting a great deal of attention as plausible candidate gene…
View article: Exercise training
Exercise training Open
Aims] Skyrunning (SR) is an extreme sport of mountain running above 2,000 meters, and the number of participants in SR is rapidly increasing in Europe.In Japan, the sport has been growing in popularity since the establishment of the Japan …