Nancy A. Obuchowski
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View article: Scalable Clinical Annotation with Location Evidence (SCALE)
Scalable Clinical Annotation with Location Evidence (SCALE) Open
Deep learning can mitigate the global radiologist shortage but its development requires large-scale annotated datasets. This study introduces SCALE (Scalable Clinical Annotation with Location Evidence), a fully automated method for generat…
View article: Poster 140: Patella Shape is Associated with ACL Injury and Changes in KOOS Following ACL Reconstruction
Poster 140: Patella Shape is Associated with ACL Injury and Changes in KOOS Following ACL Reconstruction Open
Objectives: Osteoarthritis (OA) is a heterogeneous disease characterized by progressive cartilage loss, subchondral bone remodeling, osteophyte formation, and synovial inflammation which can lead to joint pain and disability and affects an…
View article: Diffusion tensor imaging in the SPRINT-MS clinical trial: Advancing trial methodology
Diffusion tensor imaging in the SPRINT-MS clinical trial: Advancing trial methodology Open
Background SPRINT-MS was a placebo-controlled phase 2 trial of ibudilast in secondary and primary progressive multiple sclerosis. The trial included multimodal imaging to assess brain tissue integrity. This contribution focuses on improved…
View article: AI-Assisted vs Unassisted Identification of Prostate Cancer in Magnetic Resonance Images
AI-Assisted vs Unassisted Identification of Prostate Cancer in Magnetic Resonance Images Open
Importance Artificial intelligence (AI) assistance in magnetic resonance imaging (MRI) assessment for prostate cancer shows promise for improving diagnostic accuracy but lacks large-scale observational evidence. Objective To evaluate wheth…
View article: Capturing deep partial-thickness cartilage loss with semiquantitative scoring: A supplemented MRI Osteoarthritis Knee Score (sMOAKS)
Capturing deep partial-thickness cartilage loss with semiquantitative scoring: A supplemented MRI Osteoarthritis Knee Score (sMOAKS) Open
View article: Model observer task‐based assessment of computed tomography metal artifact reduction using a hip arthroplasty phantom
Model observer task‐based assessment of computed tomography metal artifact reduction using a hip arthroplasty phantom Open
Background The United States Food and Drug Administration (FDA) recently published a model observer‐based framework for the objective performance assessment of computed tomography (CT) metal artifact reduction (MAR) algorithms and demonstr…
View article: ISIT-GEN: an in silico imaging trial to assess the inter-scanner generalizability of CTLESS for myocardial perfusion SPECT on defect-detection task
ISIT-GEN: an in silico imaging trial to assess the inter-scanner generalizability of CTLESS for myocardial perfusion SPECT on defect-detection task Open
A recently proposed scatter-window and deep learning-based attenuation compensation (AC) method for myocardial perfusion imaging (MPI) by single-photon emission computed tomography (SPECT), namely CTLESS, demonstrated promising performance…
View article: 61 Phase 2 Clinical trial success: Association with statistical decision-making in preceding rodent experiments
61 Phase 2 Clinical trial success: Association with statistical decision-making in preceding rodent experiments Open
Objectives/Goals: In neurological animal research, statistical misapplication may lead to overoptimism in a therapy’s potential for successful translation. This pilot study investigated whether human clinical trials that fail have higher p…
View article: Radiomic features of infrapatellar fat pad are associated with knee symptoms and radiographic post-traumatic osteoarthritis at 10+ years after anterior cruciate ligament reconstruction
Radiomic features of infrapatellar fat pad are associated with knee symptoms and radiographic post-traumatic osteoarthritis at 10+ years after anterior cruciate ligament reconstruction Open
Radiomics features describing IPFP intensity, morphology, and texture achieve fair to moderate performance in discriminating PTOA-positive from PTOA-negative patients, defined either symptomatically or radiographically. These features desc…
View article: Comparing quantitative imaging biomarker alliance volumetric CT classifications with RECIST response categories
Comparing quantitative imaging biomarker alliance volumetric CT classifications with RECIST response categories Open
Purpose To assess agreement between CT volumetry change classifications derived from Quantitative Imaging Biomarker Alliance Profile cut-points (ie, QIBA CTvol classifications) and the Response Evaluation Criteria in Solid Tumors (RECIST) …
View article: Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis
Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis Open
Aims Sex differences in prognosis of functional mitral regurgitation (FMR) associated with ischaemic cardiomyopathy (ICM) demonstrate the need to identify sex differences in cardiac remodelling. This study aimed to characterize sex differe…
View article: The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas
The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas Open
The Quantitative Imaging Biomarkers Alliance Profile for dynamic susceptibility contrast (DSC) MRI and its longitudinal claims for the precision of a DSC MRI–derived quantitative imaging biomarker to assess the relative cerebral blood volu…
View article: Reproducibility of proton density fat fraction assessment of thigh muscle in a multi-site, multi-vendor cohort study at 10 years after anterior cruciate ligament reconstruction
Reproducibility of proton density fat fraction assessment of thigh muscle in a multi-site, multi-vendor cohort study at 10 years after anterior cruciate ligament reconstruction Open
Reproducible multi-site, multi-vendor intramuscular PDFF measurement is enabled by 6-point Dixon MRI with standardized acquisition and processing. The method is sensitive enough to detect differences in muscle groups between operated and n…
View article: CTLESS: A Scatter-Window Projection and Deep Learning-Based Transmission-Less Attenuation Compensation Method for Myocardial Perfusion SPECT
CTLESS: A Scatter-Window Projection and Deep Learning-Based Transmission-Less Attenuation Compensation Method for Myocardial Perfusion SPECT Open
Attenuation compensation (AC), while being beneficial for visual-interpretation tasks in myocardial perfusion imaging (MPI) by SPECT, typically requires the availability of a separate X-ray CT component, leading to additional radiation dos…
View article: Evaluating Biparametric Versus Multiparametric Magnetic Resonance Imaging for Diagnosing Clinically Significant Prostate Cancer: An International, Paired, Noninferiority, Confirmatory Observer Study
Evaluating Biparametric Versus Multiparametric Magnetic Resonance Imaging for Diagnosing Clinically Significant Prostate Cancer: An International, Paired, Noninferiority, Confirmatory Observer Study Open
View article: The QIBA Profile for Diffusion-Weighted MRI: Apparent Diffusion Coefficient as a Quantitative Imaging Biomarker
The QIBA Profile for Diffusion-Weighted MRI: Apparent Diffusion Coefficient as a Quantitative Imaging Biomarker Open
The claims and procedures of the Quantitative Imaging Biomarker Alliance Diffusion-Weighted Imaging Biomarker Committee are summarized for apparent diffusion coefficient as a quantitative biomarker to monitor lesions in the brain, liver, p…
View article: Special Report on the Consensus QIBA Profile for Objective Analytical Validation of Non-calcified and High-risk Plaque and Other Biomarkers using Computed Tomography Angiography
Special Report on the Consensus QIBA Profile for Objective Analytical Validation of Non-calcified and High-risk Plaque and Other Biomarkers using Computed Tomography Angiography Open
View article: Artificial intelligence and radiologists in prostate cancer detection on MRI (PI-CAI): an international, paired, non-inferiority, confirmatory study
Artificial intelligence and radiologists in prostate cancer detection on MRI (PI-CAI): an international, paired, non-inferiority, confirmatory study Open
View article: Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials
Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials Open
View article: Prospective comparison of positron emission tomography (PET)/magnetic resonance and PET/computed tomography dosimetry in hepatic malignant neoplastic disease after 90Y radioembolization treatment
Prospective comparison of positron emission tomography (PET)/magnetic resonance and PET/computed tomography dosimetry in hepatic malignant neoplastic disease after 90Y radioembolization treatment Open
Although PET/MR significantly underestimated the absorbed dose when compared to PET/CT, the intermodality agreement was high and the degree of underestimation was better than previously reported. Intermodality differences were more pronoun…
View article: METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII
METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII Open
View article: Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials
Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials Open
BACKGROUND Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients with bone-dominant metastases ineligible for clinical trials with potential…
View article: Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy
Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy Open
View article: Impact of a Sex and Comprehensive Anxiolytic Approach on Scan Duration and Image Quality During Cardiac MRI Acquisition
Impact of a Sex and Comprehensive Anxiolytic Approach on Scan Duration and Image Quality During Cardiac MRI Acquisition Open
View article: Impact of Aromatherapy as an Alternative Anxiolytic Therapy on Scan Time and Nursing Interventions for Patients Undergoing Cardiac MRI
Impact of Aromatherapy as an Alternative Anxiolytic Therapy on Scan Time and Nursing Interventions for Patients Undergoing Cardiac MRI Open
View article: Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography
Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography Open
Purpose The purpose of this investigation was to assess the effect of visceral adipose tissue volume (VA) on reader efficacy in diagnosing and characterizing small bowel Crohn's disease using lower exposure CT enterography (CTE). Secondari…
View article: METhodological RadiomICs Score (METRICS): A quality scoring tool for radiomics research
METhodological RadiomICs Score (METRICS): A quality scoring tool for radiomics research Open
View article: Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium
Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium Open
Background There is a need for reliable noninvasive methods for diagnosing and monitoring nonalcoholic fatty liver disease (NAFLD). Thus, the multidisciplinary Non-invasive Biomarkers of Metabolic Liver disease (NIMBLE) consortium was form…
View article: Calibration phantom-based prediction of CT lung nodule volume measurement performance
Calibration phantom-based prediction of CT lung nodule volume measurement performance Open
This is the first report of a calibration phantom-based method's ability to predict both small lung nodule volume measurement bias and precision. Volume measurement bias and precision for small lung nodules can be predicted using simple lo…
View article: Paper 31: Quantitative MRI of the Hamstring Muscles Ten Years After Autograft Hamstring ACLR
Paper 31: Quantitative MRI of the Hamstring Muscles Ten Years After Autograft Hamstring ACLR Open
Objectives: After autograft hamstring harvesting for anterior cruciate ligament reconstruction (ACLR) there are several studies of semitendinosus (ST) and gracilis (G) tendon showing variation in muscle/tendon regeneration, muscle atrophy …