Explanipedia

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese, Matthew Suderman , et al. · 2025

Background DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it …

Associations of fetal and infant growth patterns with behavior and cognitive outcomes in early adolescence Open

Romy Gonçalves, Romy Gaillard, Kelly K. Ferguson, Sara Sammallahti, Manon H. J. Hillegers , et al. · 2024

Background Fetal life and infancy might be critical periods for brain development leading to increased risks of neurocognitive disorders and psychopathology later in life. We examined the associations of fetal and infant weight growth patt…

Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation Open

Elizabeth W. Diemer, Johanna Tuhkanen, Sara Sammallahti, Kati Heinonen, Alexander Neumann , et al. · 2024

Low maternal vitamin D concentrations during pregnancy have been associated with a range of offspring health outcomes. DNA methylation is one mechanism by which the maternal vitamin D status during pregnancy could impact offspring's health…

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Open

Sara Sammallahti, M. Elisabeth Koopman‐Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera , et al. · 2024

Background: Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to unde…

Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression Open

Anthi C. Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link , et al. · 2024

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open

Alexander Neumann, Sara Sammallahti, Marta Cosín‐Tomás, Sarah E. Reese, Matthew Suderman , et al. · 2024

DNA methylation (DNAm) is a developmentally dynamic epigenetic process, yet we still know little about how epigenetic effects on health outcomes vary over time; whether DNAm alterations during certain periods of development are more inform…

Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy Open

Sara Sammallahti, Elisa Holmlund‐Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl , et al. · 2023

Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if materna…

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation Open

Anna Kotsakis, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder , et al. · 2023

Excessive Crying, Behavior Problems, and Amygdala Volume: A Study From Infancy to Adolescence Open

Sara Sammallahti, Fadila Serdarević, Henning Tiemeier · 2023

Excessive crying and irritability in infancy may reflect an early vulnerability to behavioral problems and may be linked with neurobiological differences in the development of the amygdala.

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health Open

Nora Fernández‐Jiménez, Ruby Fore, Ariadna Cilleros‐Portet, Johanna Lepeule, Patrice Perron , et al. · 2022

Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing Open

Darina Czamara, Cristiana Cruceanu, Marius Lahti‐Pulkkinen, Linda Dieckmann, Maik Ködel , et al. · 2022

Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher likelihood of adv…

Human neurogenesis is altered via glucocorticoid-mediated regulation of<i>ZBTB16</i>expression Open

Anthi C. Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link , et al. · 2022

Summary Glucocorticoids are important for proper organ maturation and their levels are tightly regulated during development. Here we use human cerebral organoids and mice to study cell-type specific effects of glucocorticoids on neurogenes…

Epigenome-Wide Meta-Analysis of Prenatal Maternal Stressful Life Events and Newborn DNA Methylation Open

Kelly J. Brunst, Anna Kotsakis, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski , et al. · 2022

Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biologic mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysi…

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Open

Sara Sammallahti, M. Elisabeth Koopman‐Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera , et al. · 2022

Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies Open

Linda Dieckmann, Cristiana Cruceanu, Marius Lahti‐Pulkkinen, Jari Lahti, Tuomas Kvist , et al. · 2022

The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease risk. However, DNAm…

Cohort profile: InTraUterine sampling in early pregnancy (ITU), a prospective pregnancy cohort study in Finland: study design and baseline characteristics Open

Tuomas Kvist, Sara Sammallahti, Marius Lahti‐Pulkkinen, Cristiana Cruceanu, Darina Czamara , et al. · 2022

Purpose The InTraUterine sampling in early pregnancy (ITU) is a prospective pregnancy cohort study. The overarching aim of ITU is to unravel genomic, epigenomic, transcriptomic, endocrine, inflammatory and metabolic maternal-placental-feta…

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health Open

Nora Fernández‐Jiménez, Ruby Fore, Ariadna Cilleros‐Portet, Johanna Lepeule, Patrice Perron , et al. · 2022

Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. Placenta is a key organ in fetal development …

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health Open

Nora Fernández‐Jiménez, Ruby Fore, Ariadna Cilleros‐Portet, Johanna Lepeule, Patrice Perron , et al. · 2022

Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. Placenta is a key organ in fetal development …

Maternal early‐pregnancy ferritin and offspring neurodevelopment: A prospective cohort study from gestation to school age Open

Sara Sammallahti, Henning Tiemeier, Irwin Reiss, Martina U. Muckenthaler, Hanan El Marroun , et al. · 2021

Background Iron plays a role in many key processes in the developing brain. During pregnancy, iron supplementation is widely recommended to prevent and treat iron deficiency; however, the prevalence of iron deficiency and the risk of iron …

Patterns of Fetal and Infant Growth and Brain Morphology at Age 10 Years Open

Carolina C. V. Silva, Hanan El Marroun, Sara Sammallahti, Meike W. Vernooij, Ryan L. Muetzel , et al. · 2021

This cohort study's findings suggest that both fetal and infant weight growth might be critical for cerebral and cerebellar brain volumes during childhood. Whether these associations link to neurocognitive outcomes should be further studie…

Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy Open

Sara Sammallahti, Elisa Holmlund‐Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl , et al. · 2021

Reference-Based Versus Reference-Free Cell Type Estimation In DNA Methylation Studies Using Human Placental Tissue Open

Linda Dieckmann, Cristiana Cruceanu, Marius Lahti‐Pulkkinen, Jari Lahti, Tuomas Kvist , et al. · 2021

The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates to disease risk. However, DNAm…

Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation Open

Darina Czamara, Linda Dieckmann, Simone Röh, Sarah Kraemer, Rebecca C. Rancourt , et al. · 2021

Fetal Growth Trajectories Among Small for Gestational Age Babies and Child Neurodevelopment Open

Kelly K. Ferguson, Sara Sammallahti, Emma M. Rosen, Michiel A. van den Dries, Anjoeka Pronk , et al. · 2021

Background: Being born small for gestational age (SGA, <10th percentile) is a risk factor for worse neurodevelopmental outcomes. However, this group is a heterogeneous mix of healthy and growth-restricted babies, and not all will experienc…

Characteristics of epigenetic aging across gestational and perinatal tissues Open

Linda Dieckmann, Marius Lahti‐Pulkkinen, Tuomas Kvist, Jari Lahti, Peter E. DeWitt , et al. · 2021

Background Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially regarding diffe…

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation Open

Sara Sammallahti, Andrea P. Cortés Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder , et al. · 2021

Additional file 9 of Characteristics of epigenetic aging across gestational and perinatal tissues Open

Linda Dieckmann, Marius Lahti‐Pulkkinen, Tuomas Kvist, Jari Lahti, Peter E. DeWitt , et al. · 2021

Additional file 9. Table S3: Median (MED) coefficients, 95% confidence intervals (lcl = lower confidence limit; ucl = upper confidence limit) and % of non-zero of predictor variables across 1000 bootstrap samples for the final elastic net …

Additional file 2 of Characteristics of epigenetic aging across gestational and perinatal tissues Open

Linda Dieckmann, Marius Lahti‐Pulkkinen, Tuomas Kvist, Jari Lahti, Peter E. DeWitt , et al. · 2021

Additional file 2. Table S2: Mean estimated cell-type proportions (%) and SD in every data set.

Additional file 11 of Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation Open

Darina Czamara, Linda Dieckmann, Simone Röh, Sarah Kraemer, Rebecca C. Rancourt , et al. · 2021

Additional file 11: Table S8. Biological function GO terms which are significantly enriched for genes from the turquoise module at FDR-level of 5%

Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation Open

Darina Czamara, Linda Dieckmann, Simone Roeh, Sarah Kraemer, Rebecca C. Rancourt , et al. · 2021

Background Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects of antenatal sGCs h…

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