Nancy C. Andreasen
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View article: Phase 1/2a Intravenous and Subcutaneous Oligomer-Specific Antibody KHK6640 in Mild to Moderate Alzheimer's Disease
Phase 1/2a Intravenous and Subcutaneous Oligomer-Specific Antibody KHK6640 in Mild to Moderate Alzheimer's Disease Open
KHK6640 was well-tolerated across all doses, without any amyloid-related imaging abnormalities for edema, and amyloid-related imaging abnormalities for hemorrhage was as population background. The demonstrated dose-response of specific tar…
View article: Clinical and neurobiologic predictors of long-term outcome in schizophrenia
Clinical and neurobiologic predictors of long-term outcome in schizophrenia Open
Background Schizophrenia is a severe neuropsychiatric disorder accompanied by debilitating cognitive and psychosocial impairments over the course of the disease. As disease trajectories exhibit considerable inter-individual heterogeneity, …
View article: Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion Open
16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The g…
View article: Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years Open
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association betw…
View article: Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years Open
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may…
View article: Patients on the psychosis spectrum employ an alternate brain network to engage in complex decision-making
Patients on the psychosis spectrum employ an alternate brain network to engage in complex decision-making Open
Brain reward processing mechanisms that underlie complex decision-making are compromised in psychosis. The goal of this research was to advance our understanding of the underlying (1) neural mechanisms and (2) discrete neuro-economic/motiv…
View article: Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years
Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years Open
Delineating age-related cortical trajectories in healthy individuals is critical given the association of cortical thickness with cognition and behaviour. Previous research has shown that deriving robust estimates of age-related brain morp…
View article: Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years
Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years Open
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may…
View article: Patients on the psychosis spectrum employ an alternate brain network to engage in complex decision-making
Patients on the psychosis spectrum employ an alternate brain network to engage in complex decision-making Open
Brain reward processing mechanisms that underlie complex decision-making are compromised in psychosis. The goal of this research was to advance our understanding of the underlying (1) neural mechanisms and (2) discrete neuro-economic/motiv…
View article: Forty years of structural brain imaging in mental disorders: is it clinically useful or not?
Forty years of structural brain imaging in mental disorders: is it clinically useful or not? Open
Structural brain imaging was introduced into routine clinical practice more than 40 years ago with the hope that it would support the diagnosis and treatment of mental disorders. It is now widely used to exclude organic brain disease (eg, …
View article: Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction
Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction Open
View article: Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele
Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele Open
Misfolding and aggregation of amyloid β (Aβ) are key features of Alzheimer's disease (AD) pathogenesis, but the molecular events controlling this process are not known in detail. In vivo, Aβ aggregation and plaque formation occur in the in…
View article: Childhood‐onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2–p12.1 and two large chromosomal abnormalities at 16q22.3–q24.3 and Xq23–q28
Childhood‐onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2–p12.1 and two large chromosomal abnormalities at 16q22.3–q24.3 and Xq23–q28 Open
Key Clinical Message Childhood‐onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood‐onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletio…
View article: Comparing estimated cost per patient for dementia care: Two municipalities and Swedish national population data
Comparing estimated cost per patient for dementia care: Two municipalities and Swedish national population data Open
Aim: To evaluate a collaborative dementia program for its influence on cost and in which dementia care specialists and primary care centres collaborate with the municipality and, thereby, effect direct cost of dementia care. Methods: The c…