Nan Chiang
YOU?
Author Swipe
View article: Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation
Nouveau benzo-mimetics of 17R-Resolvin D2 are potent resolution agonists for inflammation Open
The acute inflammatory response is a highly coordinated protective process governed by a superfamily of mediators termed specialized proresolving mediators. This includes the recently uncovered 17R-Resolvin D2 (17R-RvD2). We report 17R-RvD…
View article: In‐Depth Assessment of Cytologic Features in 106 Cervical Papanicolaou Tests of Transgender Male Patients on Testosterone: An Institutional Experience
In‐Depth Assessment of Cytologic Features in 106 Cervical Papanicolaou Tests of Transgender Male Patients on Testosterone: An Institutional Experience Open
Background There is a decreased cervical cancer screening rate among female to male transgender (FTMTG) patients. Data on the distinct cytologic features present in cervical cytology (CC) of those on testosterone therapy is limited. Method…
View article: Leukotriene receptors in GtoPdb v.2025.3
Leukotriene receptors in GtoPdb v.2025.3 Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [36, 39]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Formylpeptide receptors in GtoPdb v.2025.3
Formylpeptide receptors in GtoPdb v.2025.3 Open
The human formylpeptide receptor subfamily of GPCRs (FPR: nomenclature described in [169, 227] [1, 2]) comprises three members (FPR1, FPR2, and FPR3). Two of these, FPR1 and FPR2, recognize peptides bearing N-terminal formyl-Met from invad…
View article: Formylpeptide receptors in GtoPdb v.2025.1
Formylpeptide receptors in GtoPdb v.2025.1 Open
The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [150]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLF) and endogenous ligands such as lipoxi…
View article: A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva
A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva Open
Production of specialized proresolving mediators (SPMs) during the resolution phase in the acute inflammatory response is key to orchestrating complete resolution. Here, we uncovered a trihydroxy resolvin in fresh human saliva. We identifi…
View article: Understanding cytomorphologic changes in Pap tests of transgender men on testosterone therapy
Understanding cytomorphologic changes in Pap tests of transgender men on testosterone therapy Open
Introduction/Objective Pap test findings in transgender men on testosterone therapy can often lead to misdiagnosis of dysplasia, especially in the setting of a positive HPV test. We reviewed relevant literature to analyze the cytomorpholog…
View article: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: Author Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity
Author Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity Open
The original version of this Article contained an error in Fig. 1a, in which the two chromatograms for RvD2 and RvD5 were produced by re-plotting the raw LC-MS-MS output and omitting peaks considered of less relevance because there were no…
View article: Stereochemistry and functions of the new cysteinyl‐resolvin, <scp>4S</scp>,<scp>5R‐RCTR1</scp>, in efferocytosis and erythrophagocytosis of human senescent erythrocytes
Stereochemistry and functions of the new cysteinyl‐resolvin, <span>4S</span>,<span>5R‐RCTR1</span>, in efferocytosis and erythrophagocytosis of human senescent erythrocytes Open
Specialized pro‐resolving lipid mediators play key functions in the resolution of the acute inflammatory response. Herein, we elucidate the stereochemical structure of the new 4S,5R‐RCTR1, a cysteinyl‐resolvin, recently uncovered in human …
View article: Maternal-neonatal model of immune protection to type 2 pulmonary inflammation
Maternal-neonatal model of immune protection to type 2 pulmonary inflammation Open
Asthma tends to “run in families” is a concept supported by several research studies of asthma genetics, but this only explains a relatively small fraction of asthma inheritance. We are now standing this paradigm on its head by asking the …
View article: Leukotriene receptors in GtoPdb v.2023.1
Leukotriene receptors in GtoPdb v.2023.1 Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [35, 38]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Resolvin T-series reduce neutrophil extracellular traps
Resolvin T-series reduce neutrophil extracellular traps Open
The newly identified 13-series (T-series) resolvins (RvTs) regulate phagocyte functions and accelerate resolution of infectious inflammation. Because severe acute respiratory syndrome coronavirus 2 elicits uncontrolled inflammation involvi…
View article: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors Open
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasi…
View article: Formylpeptide receptors in GtoPdb v.2021.2
Formylpeptide receptors in GtoPdb v.2021.2 Open
The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [196]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as lipoxi…
View article: Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation
Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation Open
Significance Resolution of inflammation, infection, and injury are essential for host defense and homeostasis. Cysteinyl-specialized proresolving mediators (cys-SPMs) are potent chemical signals that accelerate resolution of inflammation, …
View article: Specialized pro-resolving mediator network: an update on production and actions
Specialized pro-resolving mediator network: an update on production and actions Open
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic syndrome and many other diseases of public health concern (e.g. …
View article: Leukotriene receptors (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database
Leukotriene receptors (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [34, 37]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1<sub><i>n</i>−3 DPA</sub>
Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1<sub><i>n</i>−3 DPA</sub> Open
The authors wish to provide detailed protocol that clarifies and supports their results with RvD1n−3 DPA and RvD1 in this manuscript. The following paragraph should be inserted at Line 3 on page 1479: A) Validation of n−3 DPA Resolvins The…
View article: Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions Open
Resolution of acute inflammation is an active process orchestrated by endogenous mediators and mechanisms pivotal in host defense and homeostasis. The macrophage mediator in resolving inflammation, maresin 1 (MaR1), is a potent immunoresol…
View article: Formylpeptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Formylpeptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [185]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as annexi…
View article: Leukotriene receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Leukotriene receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [31, 34]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The…
View article: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1<sub><i>n</i>−3 DPA</sub>
Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1<sub><i>n</i>−3 DPA</sub> Open
New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro‐resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying such bioactio…
View article: Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132
Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132 Open
Significance Small-molecule enhancers of hematopoietic stem cell transplant could improve the safety of this treatment and expand the pool of eligible patients. We previously showed that the lipid 11,12-epoxyeicosatrienoic acid (EET) enhan…