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View article: A <i>de novo</i> ‐assisted strategy to identify novel lncRNA‐encoded peptides in cerebrospinal fluid of demented subjects with or without amyloid positivity
A <i>de novo</i> ‐assisted strategy to identify novel lncRNA‐encoded peptides in cerebrospinal fluid of demented subjects with or without amyloid positivity Open
Background Long non‐coding RNAs (lncRNAs) play a significant role in the pathogenesis of Alzheimer's disease (AD). They modulate various cellular processes such as amyloid production, Tau hyperphosphorylation, neuroinflammation, and the im…
View article: Pregnancy pesticide exposure and child development in low- and middle-income countries: A prospective analysis of a birth cohort in rural Bangladesh and meta-analysis
Pregnancy pesticide exposure and child development in low- and middle-income countries: A prospective analysis of a birth cohort in rural Bangladesh and meta-analysis Open
Background Despite considerable evidence on a negative association between pregnancy pesticide exposure and child development in high-income countries, evidence from low- and middle-income countries (LMICs) is limited. Therefore, we assess…
View article: Accounting for <i>EGFR</i> Mutations in Epidemiologic Analyses of Non–Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data
Accounting for <i>EGFR</i> Mutations in Epidemiologic Analyses of Non–Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data Open
Background: Somatic EGFR mutations define a subset of non–small cell lung cancers (NSCLC) that have clinical impact on NSCLC risk and outcome. However, EGFR-mutation-status is often missing in epidemiologic datasets. We developed and teste…
View article: Association between initial opioid prescription diagnosis type and subsequent chronic prescription opioid use in Rhode Island: a population-based cohort study
Association between initial opioid prescription diagnosis type and subsequent chronic prescription opioid use in Rhode Island: a population-based cohort study Open
Objective To identify initial diagnoses associated with elevated risk of chronic prescription opioid use. Design Population-based, retrospective cohort study. Setting State of Rhode Island. Participants Rhode Island residents with an initi…
View article: Metabolomic profiling for second primary lung cancer: A pilot case-control study
Metabolomic profiling for second primary lung cancer: A pilot case-control study Open
SPLC cases may have distinct metabolomic profiles compared to those in IPLC patients without SPLC. A risk stratification approach integrating metabolomics may be useful for distinguishing patients based on SPLC risk. Prospective validation…
View article: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk Open
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung c…
View article: Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium
Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium Open
Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer a…
View article: Exposure Enriched Case‐Control (EECC) Design for the Assessment of Gene–Environment Interaction
Exposure Enriched Case‐Control (EECC) Design for the Assessment of Gene–Environment Interaction Open
Genetic susceptibility and environmental exposure both play an important role in the aetiology of many diseases. Case‐control studies are often the first choice to explore the joint influence of genetic and environmental factors on the ris…