Nancy E. LePard
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View article: Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs
Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs Open
Our data support the development of therapeutic strategies to target MDSCs and to monitor MDSC levels before and after primary tumor resection to enhance the effectiveness of immune-based therapies and improve the treatment of metastatic b…
View article: Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes
Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes Open
Packaging of small molecular factors, including miRNAs, into small extracellular vesicles (SEVs) may contribute to malignant phenotypes and facilitate communication between cancer cells and tumor stroma. The process by which some miRNAs ar…
View article: Maraviroc decreases CCL8-mediated migration of CCR5<sup>+</sup>regulatory T cells and reduces metastatic tumor growth in the lungs
Maraviroc decreases CCL8-mediated migration of CCR5<sup>+</sup>regulatory T cells and reduces metastatic tumor growth in the lungs Open
Regulatory T cells (Tregs) play a crucial physiological role in the regulation of immune homeostasis, although recent data suggest Tregs can contribute to primary tumor growth by suppressing antitumor immune responses. Tregs may also influ…
View article: SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice
SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice Open
SH2-containing-inositol-5'-phosphatase (SHIP) is a negative regulator of the phosphatidylinositol-3-kinase pathway in hematopoietic cells and limits the development of leukemias and lymphomas. The potential role of SHIP in solid tumor deve…