Nancy E. Rawson
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View article: Organoid models for chemosensing cell studies
Organoid models for chemosensing cell studies Open
Over the past decade, tremendous progress has been made in using organoids—three-dimensional, miniature organ-like structures—to model tissues and organs in vitro, including both regenerative tissues (which contain tissue-residing stem/pro…
View article: Integrating the Patient’s Voice into the Research Agenda for Treatment of Chemosensory Disorders
Integrating the Patient’s Voice into the Research Agenda for Treatment of Chemosensory Disorders Open
World-wide some 658 million people were infected with COVID-19 and millions suffer from chemosensory impairment associated with long COVID. Current treatments for taste and smell disorders are limited. Involving patients has the potential …
View article: Topical platelet‐rich plasma as a possible treatment for olfactory dysfunction—A randomized controlled trial
Topical platelet‐rich plasma as a possible treatment for olfactory dysfunction—A randomized controlled trial Open
Background Olfactory dysfunction (OD) affects many survivors of COVID‐19. Prior studies have investigated the use of platelet‐rich plasma (PRP) injections for OD. We describe the first randomized controlled trial investigating topical PRP …
View article: Worldwide study of the taste of bitter medicines and their modifiers
Worldwide study of the taste of bitter medicines and their modifiers Open
The bitter taste of medicines hinders patient compliance, but not everyone experiences these difficulties because people worldwide differ in their bitterness perception. To better understand how people from diverse ancestries perceive medi…
View article: Patient Insights into the Diagnosis of Smell and Taste Disorders in the United States
Patient Insights into the Diagnosis of Smell and Taste Disorders in the United States Open
OBJECTIVES Diagnosis of smell/taste dysfunction is necessary for appropriate medical care. This study examines factors affecting testing and diagnosis of smell/taste disorders. METHODS The online USA Smell and Taste Patient Survey was made…
View article: Thiazolidinediones are partially effective bitter blockers
Thiazolidinediones are partially effective bitter blockers Open
Purpose The bad bitter taste of some medicines is a barrier to overcoming non-compliance with medication use, especially life-saving drugs given to children and the elderly. Here we evaluated a new class of bitter blockers (thiazolidinedio…
View article: Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders
Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders Open
It is estimated that 20%–67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of …
View article: Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders
Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders Open
It is estimated that 20-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of t…
View article: Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway
Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway Open
The taste stimulus glucose comprises approximately half of the commercial sugar sweeteners used today, whether in the form of the di-saccharide sucrose (glucose-fructose) or half of high-fructose corn syrup (HFCS). Therefore, oral glucose …
View article: Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium
Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium Open
Neural precursors in the developing olfactory epithelium (OE) give rise to three major neuronal classes – olfactory receptor (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons. Nevertheless, the molecular and prol…
View article: Inhibition of Bitter Taste from Oral Tenofovir Alafenamide
Inhibition of Bitter Taste from Oral Tenofovir Alafenamide Open
Children have difficulty swallowing capsules. Yet, when presented with liquid formulations, children often reject oral medications due to their intense bitterness. Presently, effective strategies to identify methods, reagents, and tools to…
View article: <i>SCENTinel 1.0</i> : Development of a Rapid Test to Screen for Smell Loss
<i>SCENTinel 1.0</i> : Development of a Rapid Test to Screen for Smell Loss Open
Commercially available smell tests are primarily used in research or in-depth clinical evaluations and are too costly and time-consuming for population surveillance in health emergencies like COVID-19. To address this need, we developed th…
View article: <i>SCENTinel 1.0</i>: development of a rapid test to screen for smell loss
<i>SCENTinel 1.0</i>: development of a rapid test to screen for smell loss Open
Background Commercially available smell tests are primarily used in research or in-depth clinical evaluations, but are too costly and lengthy for population surveillance in health emergencies like COVID-19. We developed the SCENTinel 1 . 0…
View article: Studies of Human Twins Reveal Genetic Variation That Affects Dietary Fat Perception
Studies of Human Twins Reveal Genetic Variation That Affects Dietary Fat Perception Open
To learn more about the mechanisms of human dietary fat perception, we asked 398 human twins to rate the fattiness and how much they liked 6 types of potato chips that differed in triglyceride content (2.5%, 5%, 10%, and 15% corn oil); rel…
View article: Studies of human twins reveal genetic variation that affects dietary fat perception
Studies of human twins reveal genetic variation that affects dietary fat perception Open
To learn more about the mechanisms of human dietary fat perception, 398 human twins rated fattiness and liking for six types of potato chips that differed in triglyceride content (2.5, 5, 10, and 15% corn oil); reliability estimates were o…
View article: Standardization of a Videofluoroscopic Swallow Study Protocol to Investigate Dysphagia in Dogs
Standardization of a Videofluoroscopic Swallow Study Protocol to Investigate Dysphagia in Dogs Open
Background Videofluoroscopic swallow study ( VFSS ) is the gold standard for diagnosis of dysphagia in veterinary medicine but lacks standardized protocols that emulate physiologic feeding practices. Age impacts swallow function in humans …
View article: The influence of nasal airflow on respiratory and olfactory epithelial distribution in felids
The influence of nasal airflow on respiratory and olfactory epithelial distribution in felids Open
The surface area of the maxilloturbinals and fronto-ethmoturbinals is commonly used as an osteological proxy for respiratory and olfactory epithelium, respectively. However, this assumption does not fully account for animals with short sno…