Nancy E. Ward
YOU?
Author Swipe
View article: Highly Specific Detection of Oxytocin in Saliva
Highly Specific Detection of Oxytocin in Saliva Open
Oxytocin is a peptide neurophysin hormone made up of nine amino acids and is used in induction of one in four births worldwide (more than 13 percent in the United States). Herein, we have developed an antibody alternative aptamer-based ele…
View article: PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTP
PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTP Open
Summary Protein phosphatase 1 (PP1) regulates synaptic plasticity and has been described as a molecular constraint on learning and memory. There are three neuronal isoforms, PP1α, PP1β, and PP1γ, but little is known about their individual …
View article: Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission
Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission Open
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro , our previous …
View article: Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development
Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development Open
Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a known regulator of gene expression and has been shown to play roles in many physiological or pathological processes such as stem cell proliferation and skin inflammation. While NIPP1 …
View article: PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission
PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission Open
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous w…
View article: Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations Open
BEST1 is a Ca 2+ -activated Cl − channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestroph…
View article: Expression and Purification of Mammalian Bestrophin Ion Channels
Expression and Purification of Mammalian Bestrophin Ion Channels Open
The human genome encodes four bestrophin paralogs, namely BEST1, BEST2, BEST3, and BEST4. BEST1, encoded by the BEST1 gene, is a Ca2+-activated Cl- channel (CaCC) predominantly expressed in retinal pigment epithelium (RPE). The physiologic…
View article: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE
Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE Open
Mutations in the human BEST1 gene lead to retinal degenerative diseases displaying progressive vision loss and even blindness. BESTROPHIN1, encoded by BEST1, is predominantly expressed in retinal pigment epithelium (RPE), but its physiolog…
View article: Author response: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE
Author response: Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mutations in the human BEST1 …