Nancy Holroyd
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View article: Canonical WNT signalling governs Echinococcus metacestode development
Canonical WNT signalling governs Echinococcus metacestode development Open
Alveolar echinococcosis (AE) is a lethal zoonosis caused by infiltrative growth of the metacestode larva of the tapeworm Echinococcus multilocularis in host organs. We previously showed that the Echinococcus metacestode is an evolutionaril…
View article: Project Psyche sample collection to genome assembly publication workflow v1
Project Psyche sample collection to genome assembly publication workflow v1 Open
This protocol summarises the workflow employed by Project Psyche (https://www.projectpsyche.org/) – a collaborative project which aims to generate chromosome-level reference genomes for all 11,000 species of Lepidoptera found in Europe.
View article: Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta
Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta Open
The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goats in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of drug re…
View article: The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in <i>Schistosoma mansoni</i>
The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in <i>Schistosoma mansoni</i> Open
Studies on transcription regulation in platyhelminth development are scarce, especially for parasitic flatworms. Here, we employed single-cell transcriptomics to identify genes involved in reproductive development in the trematode model Sc…
View article: Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta
Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta Open
The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goat farming in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of …
View article: Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function
Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function Open
The lethal zoonosis alveolar echinococcosis is caused by tumour-like growth of the metacestode stage of the tapeworm Echinococcus multilocularis within host organs. We previously demonstrated that metacestode proliferation is exclusively d…
View article: The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages
The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages Open
View article: Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map
Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map Open
View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: NCTC3000: a century of bacterial strain collecting leads to a rich genomic data resource
NCTC3000: a century of bacterial strain collecting leads to a rich genomic data resource Open
The National Collection of Type Cultures (NCTC) was founded on 1 January 1920 in order to fulfil a recognized need for a centralized repository for bacterial and fungal strains within the UK. It is among the longest-established collections…
View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: Genomic landscape of drug response reveals mediators of anthelmintic resistance
Genomic landscape of drug response reveals mediators of anthelmintic resistance Open
View article: Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities
Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities Open
Populations within schistosomiasis control areas, especially those in Africa, are recommended to receive regular mass drug administration (MDA) with praziquantel (PZQ) as the main strategy for controlling the disease. The impact of PZQ tre…
View article: Specimen and sample metadata standards for biodiversity genomics: a proposal from the Darwin Tree of Life project
Specimen and sample metadata standards for biodiversity genomics: a proposal from the Darwin Tree of Life project Open
The vision of the Earth BioGenome Project1 is to complete reference genomes for all of the planet’s ~2M described eukaryotic species in the coming decade. To contribute to this global endeavour, the Darwin Tree of Life Project (DToL2) was…
View article: Defining the early stages of intestinal colonisation by whipworms
Defining the early stages of intestinal colonisation by whipworms Open
Whipworms are large metazoan parasites that inhabit multi-intracellular epithelial tunnels in the large intestine of their hosts, causing chronic disease in humans and other mammals. How first-stage larvae invade host epithelia and establi…
View article: Genome-wide analysis of<i>Schistosoma mansoni</i>reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities
Genome-wide analysis of<i>Schistosoma mansoni</i>reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities Open
Populations within schistosomiasis control areas, especially those in Africa, are recommended to receive regular mass drug administration (MDA) with praziquantel (PZQ) as the main strategy for controlling the disease. The impact of PZQ tre…
View article: Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis Open
Schistosomes cause schistosomiasis, the world’s second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable…
View article: Schistosoma bovis assembly SBOS_v1.1_pilon.fasta
Schistosoma bovis assembly SBOS_v1.1_pilon.fasta Open
Using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis
View article: Schistosoma bovis assembly SBOS_v1.1_pilon.fasta
Schistosoma bovis assembly SBOS_v1.1_pilon.fasta Open
Using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis
View article: Schistosoma bovis assembly SBOS_v1.1_pilon.fasta
Schistosoma bovis assembly SBOS_v1.1_pilon.fasta Open
Using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis
View article: Daily rhythms in gene expression of the human parasite Schistosoma mansoni
Daily rhythms in gene expression of the human parasite Schistosoma mansoni Open
Background The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. U…
View article: Genomic landscape of drug response reveals novel mediators of anthelmintic resistance
Genomic landscape of drug response reveals novel mediators of anthelmintic resistance Open
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is key to improving the efficacy and sustainability of parasite control. Here, we use a genetic cross in a natural host-parasite system to simultaneousl…
View article: Assembled chromosomes of the blood fluke <i>Schistosoma mansoni</i> provide insight into the evolution of its ZW sex-determination system
Assembled chromosomes of the blood fluke <i>Schistosoma mansoni</i> provide insight into the evolution of its ZW sex-determination system Open
Background Schistosoma mansoni is a flatworm that causes a neglected tropical disease affecting millions worldwide. Most flatworms are hermaphrodites but schistosomes have genotypically determined male (ZZ) and female (ZW) sexes. Sex is es…
View article: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration Open
View article: Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system Open
<p><em>Schistosoma mansoni </em>has a diploid genome of approximately 380 MB, organized in 7 pairs of autosomes and 2 sex chromosomes. The original <em>Schistosoma mansoni </em>Genome Project was completed by …
View article: Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system Open
Schistosoma mansoni has a diploid genome of approximately 380 MB, organized in 7 pairs of autosomes and 2 sex chromosomes. The original Schistosoma mansoni Genome Project was completed by the Wellcome Sanger Institute in …
View article: Data release: Population genomics of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration
Data release: Population genomics of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration Open
Source data used in the publication: Berger et al. (2021) - Provisional title: 'Population genomics of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration'. These data were used …
View article: Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration Open
Source data used in the publication: Berger et al. (2021) - Provisional title: 'Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration'. These data were u…
View article: Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration
Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration Open
Source data used in the publication: Berger et al. (2021) - Provisional title: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite repeated mass drug administration. These data…
View article: Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
Data release: Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration Open
Source data used in the publication: Berger et al. (2021) - Provisional title: 'Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration'. These data were u…