Nancy L. Weigel
YOU?
Author Swipe
View article: 3C. 3-Ketosteroid receptors in GtoPdb v.2025.3
3C. 3-Ketosteroid receptors in GtoPdb v.2025.3 Open
Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 221, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids …
View article: 3C. 3-Ketosteroid receptors in GtoPdb v.2023.1
3C. 3-Ketosteroid receptors in GtoPdb v.2023.1 Open
Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids …
View article: Data from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Data from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen receptor (AR) signaling, in part by elevated expression of AR splice variants (ARv) including ARv7, a constitutively active, ligand binding domain (LB…
View article: Supplementary Table 3 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 3 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
AR signature in LNCaP cells
View article: Figure S4 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S4 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Effect of JG98 on endogenous or exogenous FL-AR/ARv7 protein/target gene expression; cell lysate input for Figure 4A
View article: Supplementary Methods & Figure Legends from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Supplementary Methods & Figure Legends from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
A Word file that contains Supplementary Methods & Figure Legends
View article: Figure S5 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S5 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Average mouse body weight for Figure 5; PD analyses of C86 +/- JG98 in vivo; in vitro effects of C86 +/- JG98 on other client proteins
View article: Figure S1 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S1 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Structure of C86 and its effects on endogenous or exogenous FL-AR/ARv7 protein/target gene expression and VCaP viability
View article: Supplementary table 7 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary table 7 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
Correlation analysis between NCOR1 and NCOR2 expression and AR transcriptional output
View article: Supplementary Table 2 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 2 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
DHT regulated pathways
View article: Figure S1 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S1 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Structure of C86 and its effects on endogenous or exogenous FL-AR/ARv7 protein/target gene expression and VCaP viability
View article: Data from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Data from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
Purpose: Castration therapy in advanced prostate cancer eventually fails and leads to the development of castration-resistant prostate cancer (CRPC), which has no cure. Characteristic features of CRPC can be increased androgen recep…
View article: Supplementary Table 1 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 1 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
NCOR1 regulated pathways
View article: Figure S3 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S3 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Cell lysate inputs for Figure 3
View article: Supplementary Figures from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Figures from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
Supplementary Figure 1 Comparison of NCOR1 and NCOR2 knockdown in LAPC4 and LNCaP cells Supplementary Figure 2 NCOR1 regulates motility of LNCaP cells Supplementary Figure 3 AR signature is present among bicalutamide treated genes in both …
View article: Supplementary Table 2 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 2 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
DHT regulated pathways
View article: Supplementary Table 3 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 3 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
AR signature in LNCaP cells
View article: Supplementary Table 4 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 4 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
SIAH2 signature in LNCaP cells
View article: Figure S2 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S2 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Effects of biotinylated-C86 on binding of purified Hsp40/Hsp70/Hsp90 protein; effect of 17-AAG on FL-AR/ARv7 protein; cell lysate inputs for Figure 2
View article: Figure S4 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S4 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Effect of JG98 on endogenous or exogenous FL-AR/ARv7 protein/target gene expression; cell lysate input for Figure 4A
View article: Supplementary table 7 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary table 7 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
Correlation analysis between NCOR1 and NCOR2 expression and AR transcriptional output
View article: Figure S5 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S5 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Average mouse body weight for Figure 5; PD analyses of C86 +/- JG98 in vivo; in vitro effects of C86 +/- JG98 on other client proteins
View article: Supplementary Table 5 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 5 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
Sequences of siRNAs and primers and probes for qPCR
View article: Figure S2 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S2 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Effects of biotinylated-C86 on binding of purified Hsp40/Hsp70/Hsp90 protein; effect of 17-AAG on FL-AR/ARv7 protein; cell lysate inputs for Figure 2
View article: Figure S3 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Figure S3 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Cell lysate inputs for Figure 3
View article: Supplementary Methods & Figure Legends from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Supplementary Methods & Figure Legends from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
A Word file that contains Supplementary Methods & Figure Legends
View article: Supplementary Table 4 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary Table 4 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
SIAH2 signature in LNCaP cells
View article: Supplementary table 6 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary table 6 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
NCOR1 signature
View article: Supplementary table 6 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Supplementary table 6 from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression Open
NCOR1 signature
View article: Data from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
Data from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer Open
Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen receptor (AR) signaling, in part by elevated expression of AR splice variants (ARv) including ARv7, a constitutively active, ligand binding domain (LB…