Nancy J. Phillips
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View article: Giant Cell Arteritis Refractory to Interleukin‐6 and Interleukin‐17 Inhibition Treated With Upadacitinib
Giant Cell Arteritis Refractory to Interleukin‐6 and Interleukin‐17 Inhibition Treated With Upadacitinib Open
Giant cell arteritis (GCA) is a granulomatous vasculitis that can involve both cranial and extracranial vessels. Although interleukin‐6 (IL‐6) receptor blockade is an established therapy, treatment options for medically refractory disease …
View article: Immunity Against Mycobacterium avium Induced by DAR-901 and BCG
Immunity Against Mycobacterium avium Induced by DAR-901 and BCG Open
Background: The prevalence of pulmonary nontuberculous mycobacteria (NTM) is increasing in Europe and North America. Most pulmonary NTM cases are caused by Mycobacterium avium complex (MAC). The treatment of pulmonary MAC is suboptimal wit…
View article: Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae
Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae Open
The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea. Neisseria gonorrhoeae strains FA1090 and MS11 have been used in challenge studies in hum…
View article: Augmenting endometriosis analysis from ultrasound data with deep learning
Augmenting endometriosis analysis from ultrasound data with deep learning Open
Endometriosis is a non-malignant disorder that affects 176 million women globally. Diagnostic delays result in severe dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Therefore, there is a significant need to diagnose patie…
View article: Capture, Release, and Identification of Newly Synthesized Proteins for Improved Profiling of Functional Translatomes
Capture, Release, and Identification of Newly Synthesized Proteins for Improved Profiling of Functional Translatomes Open
New protein synthesis is regulated both at the level of mRNA transcription and translation. RNA-Seq is effective at measuring levels of mRNA expression, but techniques to monitor mRNA translation are much more limited. Previously, we repor…
View article: Regulation of eIF4E guides a unique translational program to control erythroid maturation
Regulation of eIF4E guides a unique translational program to control erythroid maturation Open
Translation control is essential in balancing hematopoietic precursors and differentiation; however, the mechanisms underlying this program are poorly understood. We found that the activity of the major cap-binding protein eIF4E is unexpec…
View article: Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows
Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows Open
Teat disinfection is a common pre- and post-milking mastitis prevention practice that is part of a mastitis control program in dairy herds. Commercially available teat disinfectants are generally chemical-based products. The use of these p…
View article: Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS
Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS Open
Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-κB via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor…
View article: Table of contents
Table of contents Open
Study Cover Figure: C-X-C motif chemokine ligand 1 (CXCL1)induced neutrophil infiltration and reactive oxygen species (ROS) production activates ROS-sensitive kinases and their downstream stress kinases (p38 and JNK) and subsequently enhan…
View article: Establishment of a Patient‐Derived Xenograft Tumor From Hepatitis C–Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy
Establishment of a Patient‐Derived Xenograft Tumor From Hepatitis C–Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy Open
Background and Aims Chronic hepatitis C virus (HCV) infection is one of the major causal factors for hepatocellular carcinoma (HCC). The treatment options for HCC are limited for lack of a convenient animal model for study in HCV infection…
View article: Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations Open
Context.— Familial adenomatous polyposis (FAP) is a rare genetic disorder with autosomal dominant inheritance, defined by numerous adenomatous polyps, which inevitably progress to colorectal carcinoma unless detected and managed early. Gre…
View article: Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence
Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence Open
The pathogenicity of Campylobacter concisus, increasingly found in the human gastrointestinal (GI) tract, is unclear. Some studies indicate that its role in GI conditions has been underestimated, whereas others suggest that the organism ha…
View article: Revealing nascent proteomics in signaling pathways and cell differentiation
Revealing nascent proteomics in signaling pathways and cell differentiation Open
Significance Deciphering which networks of genes allow cells to rapidly respond to environmental cues is key to understanding processes such as proliferation, differentiation, and death. Here, we describe a technique to quantitatively iden…
View article: Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections
Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections Open
Infections due to Neisseria meningitidis afflict more than one million people worldwide annually and cause death or disability in many survivors. The clinical course of invasive infections has been well studied, but our understanding of th…
View article: Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding Open
Significance At this time, multidrug-resistant gram-negative bacteria are estimated to cause approximately 700,000 deaths per year globally, with a prediction that this figure could reach 10 million a year by 2050. Antivirulence therapy, i…
View article: Gastric heterotopia in rectum: A literature review and its diagnostic pitfall
Gastric heterotopia in rectum: A literature review and its diagnostic pitfall Open
Objectives: The term heterotopia, in pathology, refers to the presence of normal tissues at foreign sites. Gastric heterotopia has been reported anywhere in the gastrointestinal tract. However, the presence of gastric heterotopia in the re…
View article: Involvement of c-Fos in the Promotion of Cancer Stem-like Cell Properties in Head and Neck Squamous Cell Carcinoma
Involvement of c-Fos in the Promotion of Cancer Stem-like Cell Properties in Head and Neck Squamous Cell Carcinoma Open
Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Although improvements in surgical techniques, chemotherapy and radiation delivery, and supportive care have improved quality of life for pati…
View article: Isolated craniopharyngioma in the nasal cavity
Isolated craniopharyngioma in the nasal cavity Open
We describe the occurrence of a papillary squamous infrasellar craniopharyngioma isolated to the nasal cavity and maxillary sinus in a 48-year-old male presenting with epistaxis and nasal obstruction. Diagnosis was made by histological ana…
View article: Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage
Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage Open
The degree of phosphorylation and phosphoethanolaminylation of lipid A on neisserial lipooligosaccharide (LOS), a major cell-surface antigen, can be correlated with inflammatory potential and the ability to induce immune tolerance in vitro…
View article: An Obturation Technique for Closure of Body Wall Defects
An Obturation Technique for Closure of Body Wall Defects Open
Aims:In the vast majority of instances, closure of abdominal wall defects relies on the tensile strength of transposed native tissue and/or prosthetic material.The purpose of this report is to alert clinicians to a different strategy for c…