Nancy Pleshko
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The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur Open
Bone mechanical function is determined by multiple factors, some of which are still being elucidated. Here, we present a multivariate analysis of the role of bone tissue composition in the proximal femur stiffness of cadaver bones (n = 12,…
In Situ Assessment of Porcine Osteochondral Repair Tissue in the Visible–Near Infrared Spectral Region Open
Standard assessment of cartilage repair progression by visual arthroscopy can be subjective and may result in suboptimal evaluation. Visible–near infrared (Vis-NIR) fiber optic spectroscopy of joint tissues, including articular cartilage a…
Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs Open
The synovial cavity and its fluid are essential for joint function and lubrication, but their developmental biology remains largely obscure. Here, we analyzed E12.5 to E18.5 mouse embryo hindlimbs and discovered that cavitation initiates a…
Nondestructive assessment of tissue engineered cartilage based on biochemical markers in cell culture media: application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy Open
ATR spectral data obtained from cell culture medium discards can be used to assess glucose and lactate content, which are shown here to be a surrogate for matrix development in tissue engineered cartilage.
View article: Hesperidin Promotes Osteogenesis and Modulates Collagen Matrix Organization and Mineralization In Vitro and In Vivo
Hesperidin Promotes Osteogenesis and Modulates Collagen Matrix Organization and Mineralization In Vitro and In Vivo Open
This study evaluated the direct effect of a phytochemical, hesperidin, on pre-osteoblast cell function as well as osteogenesis and collagen matrix quality, as there is little known about hesperidin’s influence in mineralized tissue formati…
View article: Characterization of Collagen Structure in Normal, Wooden Breast and Spaghetti Meat Chicken Fillets by FTIR Microspectroscopy and Histology
Characterization of Collagen Structure in Normal, Wooden Breast and Spaghetti Meat Chicken Fillets by FTIR Microspectroscopy and Histology Open
Recently, two chicken breast fillet abnormalities, termed Wooden Breast (WB) and Spaghetti Meat (SM), have become a challenge for the chicken meat industry. The two abnormalities share some overlapping morphological features, including myo…
Applications of Vibrational Spectroscopy for Analysis of Connective Tissues Open
Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key e…
View article: Characterization of Collagen Structure in Normal, Wooden Breast and Spaghetti Meat Chicken Fillets by FTIR Microspectroscopy and Histology
Characterization of Collagen Structure in Normal, Wooden Breast and Spaghetti Meat Chicken Fillets by FTIR Microspectroscopy and Histology Open
Recently, two chicken breast fillet abnormalities, termed Wooden Breast (WB) and Spaghetti Meat (SM), have become a challenge for the chicken meat industry. The two abnormalities share some overlapping morphological features, including myo…
Glycosylation and Cross-linking in Bone Type I Collagen Open
Fibrillar type I collagen is the major organic component in bone, providing a stable template for mineralization. During collagen biosynthesis, specific hydroxylysine residues become glycosylated in the form of galactosyl- and glucosylgala…
Unusual Fragmentation Pathways in Collagen Glycopeptides Open
Collagens are the most abundant glycoproteins in the body. One characteristic of this protein family is that the amino acid sequence consists of repeats of three amino acids –(X—Y—Gly)n. Within this motif, the Y residue is often 4-hydroxyp…
Temporal Changes in Collagen Cross-Links in Spontaneous Articular Cartilage Repair Open
Little is known about how the biochemical properties of collagen change during tissue regeneration following cartilage damage. In the current study, temporal changes in cartilage repair tissue biochemistry were assessed in a rabbit osteoch…
DMOG Negatively Impacts Tissue Engineered Cartilage Development Open
Objective Articular cartilage exists in a hypoxic environment, which motivates the use of hypoxia-simulating chemical agents to improve matrix production in cartilage tissue engineering. The aim of this study was to investigate whether dim…
Approaches for <i>In Situ</i> Monitoring of Matrix Development in Hydrogel-Based Engineered Cartilage Open
Near infrared (NIR) spectroscopy using a fiber optic probe shows great promise for the nondestructive in situ monitoring of tissue engineered construct development; however, the NIR evaluation of matrix components in samples with high wate…
Near infrared spectroscopic assessment of loosely and tightly bound cortical bone water Open
NIR spectroscopy can differentiate water loosely bound to bone tissue, and tightly bound to either collagen or mineral.
Fourier transform infrared spectroscopy of developing bone mineral: from amorphous precursor to mature crystal Open
The developing bone mineral is comprised by an amorphous component prior to apatite crystallization.
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
Ethics of Using Animal Models as Predictors of Human Response in Tissue Engineering Open
Use of outcomes from animal research for prediction of human response in tissue engineering studies has many ethical considerations. This article aims to contribute to the ethical discussion by delineating the framework of animal research …
Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function Open
We have reported that recombinant biglycan (BGN) core protein accelerates bone formation in vivo by enhancing bone morphogenetic protein (BMP)-2 function. The purpose of the present study was to identify the specific domain (“effector”) wi…
Non-Destructive Spectroscopic Assessment of High and Low Weight Bearing Articular Cartilage Correlates with Mechanical Properties Open
Objective Autologous articular cartilage (AC) harvested for repair procedures of high weight bearing (HWB) regions of the femoral condyles is typically obtained from low weight bearing (LWB) regions, in part due to the lack of non-destruct…
View article: Adele Ludin Boskey, PhD
Adele Ludin Boskey, PhD Open
The orthopedic community has lost one of its most prestigious and beloved scientists. Adele Ludin Boskey, PhD, passed away on May 2, 2017 in New York City. A memorial service was held at the Hospital for Special Surgery (HSS) on May 17, 20…
Near-Infrared Spectroscopy Predicts Compositional and Mechanical Properties of Hyaluronic Acid-Based Engineered Cartilage Constructs Open
Hyaluronic acid (HA) has been widely used for cartilage tissue engineering applications. However, the optimal time point to harvest HA-based engineered constructs for cartilage repair is still under investigation. In this study, we investi…
Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties Open
Articular cartilage degeneration causes pain and reduces the mobility of millions of people annually. Regeneration of cartilage is challenging, due in part to its avascular nature, and thus tissue engineering approaches for cartilage repai…
View article: Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion
Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion Open
The anterior cruciate ligament (ACL)‐to‐bone interface constitutes a complex, multi‐tissue structure comprised of contiguous ligament, non‐mineralized fibrocartilage, mineralized fibrocartilage, and bone regions. This composite structure e…