Nancy Schwarting
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View article: The minor allele of Ptpn22 changes pro-inflammatory cytokine production in dendritic cells 4699
The minor allele of Ptpn22 changes pro-inflammatory cytokine production in dendritic cells 4699 Open
Description Dendritic cells (DCs) produce cytokines with direct antiviral properties, such as type I interferon (IFN-I), as well as polarizing cytokines that promote T cell differentiation (e.g. IL-12). Previously, we found that the common…
View article: The autoimmunity-associated minor allele of PTPN22 enhances innate antiviral immunity during coronavirus infection 3695
The autoimmunity-associated minor allele of PTPN22 enhances innate antiviral immunity during coronavirus infection 3695 Open
Description Allelic variation can impact viral clearance and disease severity. Mice expressing the autoimmunity-associated allelic variant of Ptpn22 (PEP-R619W) clear chronic LCMV-cl13 infection whereas PEP-WT mice do not. However, little …
View article: PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses
PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses Open
PARP14 is a 203 kDa multi-domain protein that is primarily known as an ADP-ribosyltransferase and is involved in a variety of cellular functions, including DNA damage, microglial activation, inflammation, and cancer progression. In additio…
View article: Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle Open
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins. Mac1 is a key virulence factor that counters antiviral ADP-ribos…
View article: An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infection
An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infection Open
Allelic variation can impact viral clearance and disease severity. Still, our understanding of the effect of the autoimmunity-associated allelic variant of Ptpn22 (PEP-R619W) on antiviral immunity remains incomplete, as previous reports ha…
View article: Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle Open
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins. Mac1 is a key virulence factor that counters antiviral ADP-ribos…
View article: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner Open
ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains. Several ARTs, also known a…
View article: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner Open
ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains. Several ARTs, also known a…
View article: Activity of CcpA-Regulated GH18 Family Glycosyl Hydrolases That Contributes to Nutrient Acquisition and Fitness in Enterococcus faecalis
Activity of CcpA-Regulated GH18 Family Glycosyl Hydrolases That Contributes to Nutrient Acquisition and Fitness in Enterococcus faecalis Open
Enterococcus faecalis has emerged as a multidrug-resistant (MDR) nosocomial pathogen that causes life-threatening health care-associated infections. Nutrient acquisition systems and immune evasion strategies are key factors that contribute…
View article: Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication
Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication Open
In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conser…
View article: An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication
An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication Open
All coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in non-structural protein 3 (nsp3) which binds and hydrolyzes ADP-ribose covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent viru…
View article: Involvement of Chromosomally Encoded Homologs of the RRNPP Protein Family in Enterococcus faecalis Biofilm Formation and Urinary Tract Infection Pathogenesis
Involvement of Chromosomally Encoded Homologs of the RRNPP Protein Family in Enterococcus faecalis Biofilm Formation and Urinary Tract Infection Pathogenesis Open
Enterococcus faecalis causes health care-associated infections and displays resistance to a variety of broad-spectrum antibiotics by acquisition of resistance traits as well as the ability to form biofilms. Even though a growing number of …