Nancy Vargas
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View article: A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA Signaling
A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA Signaling Open
Our new genetic model implicates ADAR1-mediated dsRNA signaling in gastric pre-neoplasia.
View article: Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis
Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis Open
Sickle cell disease, is a genetic disorder caused by a mutation in the HBB gene, affecting the β-globin and resulting in the formation of sickle hemoglobin. The disease can affect the kidney through various mechanisms, including vaso-occlu…
View article: Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis
Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis Open
Sickle cell disease, is a genetic disorder caused by a mutation in the HBB gene, affecting the β-globin and resulting in the formation of sickle hemoglobin. The disease can affect the kidney through various mechanisms, including vaso-occlu…
View article: Barriers and Facilitators of Colonoscopy Screening Among Latino Men in a Colorectal Cancer Screening Promotion Program
Barriers and Facilitators of Colonoscopy Screening Among Latino Men in a Colorectal Cancer Screening Promotion Program Open
Colorectal cancer (CRC) is the second leading cause of cancer death among Latino men in the United States, yet they have low screening rates. This study explored barriers and facilitators of colonoscopy screening among Latino participants …
View article: Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium
Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium Open
Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA…
View article: Calcinosis cutis distrófica en un paciente con dermatomiositis clásica
Calcinosis cutis distrófica en un paciente con dermatomiositis clásica Open
A 41-year-old woman with past medical history of dermatomyositis diagnosed 6 years earlier, on treatment with prednisone and hydroxychloroquine. She had been well until 3 months before her admission, when she began with multiple and painfu…
View article: BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion
BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion Open
The exocrine pancreas can give rise to endocrine insulin-producing cells upon ectopic expression of key transcription factors. However, the need for genetic manipulation remains a translational hurdle for diabetes therapy. Here we report t…