Nancy Varice
YOU?
Author Swipe
View article: Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?
Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact? Open
PURPOSE Although germline genetic testing (GT) is recommended for all patients with ovarian cancer (OC) and some patients with endometrial cancer (EC), uptake remains low with multiple barriers. Our center performs GT in parallel with soma…
View article: Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA
Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA Open
Drug resistance is the major cause of therapeutic failure in high-grade serous ovarian cancer (HGSOC). Yet, the mechanisms by which tumors evolve to drug resistant states remains largely unknown. To address this, we aimed to exploit clone-…
View article: Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer
Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer Open
Whole-genome doubling (WGD) is a critical driver of tumor development and is linked to drug resistance and metastasis in solid malignancies. Here, we demonstrate that WGD is an ongoing mutational process in tumor evolution. Using single-ce…