Nandita Rani Das
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View article: Prion protein protects mice from lethal infection with influenza A viruses
Prion protein protects mice from lethal infection with influenza A viruses Open
The cellular prion protein, designated PrPC, is a membrane glycoprotein expressed abundantly in brains and to a lesser extent in other tissues. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in p…
View article: Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice
Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice Open
Conformational conversion of the cellular isoform of prion protein, PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie …
View article: Prions amplify through degradation of the VPS10P sorting receptor sortilin
Prions amplify through degradation of the VPS10P sorting receptor sortilin Open
Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of pri…
View article: Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line
Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line Open
Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell lin…