Explanipedia

A 2025-update of “historical evolution of ideas on eclampsia/preeclampsia’’ (2017, workshop reunion 2016) Open

Pierre Robillard, Nándor Gábor Than, Silvia Iacobelli, Francesco Bonsante, Malik Boukerrou , et al. · 2025

This paper updates the 2017 article, "Historical Evolution of Ideas on clampsia/Preeclampsia: A Proposed Optimistic View of Preeclampsia", published in the Journal of Reproductive Immunology, incorporating advances in preeclampsia research…

Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface Open

Eszter Tóth, Máté Posta, Dániel Györffy, Orsolya Oravecz, E Farkas , et al. · 2025

Introduction Miscarriages affect 50-70% of all gestations and 15-20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL) occurs in 1-5% of clinical pregnancies and has an enormous demographic impact. However, the etiologie…

Maternal and placental galectins: key players in the feto-maternal symbiotic tango Open

Orsolya Oravecz, Yiran Xie, Andrea Balogh, Máté Posta, Charlotte Harms , et al. · 2025

Galectins, a family of β-galactoside-binding proteins, are critical in regulating feto-maternal interactions during pregnancy. Their evolutionary trajectory is reflected in their expression patterns and diverse functions in embryo implanta…

The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta Open

Gudrun Meinhardt, Hanna Waldhäusl, Andreas Ian Lackner, Jasmin Wächter, Theresa Maxian , et al. · 2025

Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epit…

The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells Open

Julianna Novák, Tamás Takács, Álmos Tilajka, Loretta László, Orsolya Oravecz , et al. · 2025

Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is a double-edged sword in immunity. On one hand, it plays a crucial role in regulating diverse immune cell functions, including the apoptosis of activated T …

Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia Open

L. Gál, Ábel Fóthi, G. Oròsz, Sándor Nagy, Nándor Gábor Than , et al. · 2024

Introduction Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset hypertension and proteinuria and it is often associated with fetal intrauterine growth restriction (IUGR). PE leads to long-term health complication…

Decreased Expression of Placental Proteins in Recurrent Pregnancy Loss: Functional Relevance and Diagnostic Value Open

Eszter Tóth, Dániel Györffy, Máté Posta, Petronella Hupuczi, Andrea Balogh , et al. · 2024

Miscarriages affect 50–70% of all conceptions and 15–20% of clinically recognized pregnancies. Recurrent pregnancy loss (RPL, ≥2 miscarriages) affects 1–5% of recognized pregnancies. Nevertheless, our knowledge about the etiologies and pat…

Quantitative Discrimination of Small for Gestational Age (Sga) Singleton Newborns. Incidences, Risk Factors and Foetal Outcomes of the Three Major Subtypes of Sga: A 23-Year Cohort of 8,601 Singleton Sga (Out of 83,917 Births) Open

Pierre‐Yves Robillard, Gustaaf Dekker, Nándor Gábor Than, Francesco Bonsante, Malik Boukerrou , et al. · 2024

Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention Open

Nándor Gábor Than, Roberto Romero, Máté Posta, Dániel Györffy, Gábor Szalai , et al. · 2023

The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinical…

Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma Open

Nardhy Gomez‐Lopez, Roberto Romero, María Fernanda Escobar, Javier Carvajal, Maria Paula Echavarría , et al. · 2023

The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma Open

Gaurav Bhatti, Roberto Romero, Nardhy Gomez‐Lopez, Tinnakorn Chaiworapongsa, Nándor Gábor Than , et al. · 2023

Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death Open

Dahiana M. Gallo, Wendy Fitzgerald, Roberto Romero, Nardhy Gomez‐Lopez, Dereje W. Gudicha , et al. · 2023

Pregnant women with fetal death have different concentrations of 19 proteins in the EV and soluble fractions compared to controls, and the direction of changes in concentration was similar between fractions. The combination of EV and solub…

Acute pyelonephritis in pregnancy and plasma syndecan-1: evidence of glycocalyx involvement Open

Timothy Immonen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz‐Primera, Francesca Gotsch , et al. · 2023

Plasma syndecan-1 concentration is higher in pregnant women and increases as a function of gestational age. Patients with acute pyelonephritis have a higher plasma concentration of syndecan-1, and this is particularly the case in the prese…

Maternal plasma syndecan-1: a biomarker for fetal growth restriction Open

Alexander Juusela, Eunjung Jung, Dahiana M. Gallo, Mariachiara Bosco, Manaphat Suksai , et al. · 2023

Low maternal plasma syndecan-1 may reflect placental diseases and this protein could be a biomarker for fetal growth restriction. However, as a sole biomarker for this condition, its accuracy is low.

Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death Open

Dahiana M. Gallo, Wendy Fitzgerald, Roberto Romero, Nardhy Gomez‐Lopez, Dereje W. Gudicha , et al. · 2023

Fetal death is a complication of pregnancy caused by multiple etiologies rather than being the end-result of a single disease process. Many soluble analytes in the maternal circulation, such as hormones and cytokines, have been implicated …

Placental galectins regulate innate and adaptive immune responses in pregnancy Open

Orsolya Oravecz, Roberto Romero, Eszter Tóth, Judit Kapitány, Máté Posta , et al. · 2022

Introduction Galectins are master regulators of maternal immune responses and placentation in pregnancy. Galectin-13 (gal-13) and galectin-14 (gal-14) are expressed solely by the placenta and contribute to maternal-fetal immune tolerance b…

Perturbations in kinetics of the thrombin generation assay identify women at risk of preeclampsia in the first trimester and provide the rationale for a preventive approach Open

Offer Erez, Francesca Gotsch, Eunjung Jung, Tinnakorn Chaiworapongsa, Dereje W. Gudicha , et al. · 2022

Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention Open

Nándor Gábor Than, Roberto Romero, Dániel Györffy, Máté Posta, Gaurav Bhatti , et al. · 2022

Objectives The heterogeneous nature of preeclampsia is a major obstacle to early screening and prevention, and a molecular taxonomy of disease is needed. We have previously identified four subclasses of preeclampsia based on first-trimeste…

Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma Open

Nardhy Gomez‐Lopez, Roberto Romero, María Fernanda Escobar, Javier Carvajal, Maria Paula Echavarría , et al. · 2022

Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we …

Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas Open

Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhász , et al. · 2022

Proteoglycan macromolecules play key roles in several physiological processes (e.g., adhesion, proliferation, migration, invasion, angiogenesis, and apoptosis), all of which are important for placentation and healthy pregnancy. However, th…

Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies Open

Nándor Gábor Than, Máté Posta, Dániel Györffy, László Orosz, G. Oròsz , et al. · 2022

Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease Open

Zoltán Szabolcsi, Amanda Demeter, Péter Király, Andrea Balogh, Melissa L. Wilson , et al. · 2021

Gestational trophoblastic diseases (GTDs) have not been investigated for their epigenetic marks and consequent transcriptomic changes. Here, we analyzed genome-wide DNA methylation and transcriptome data to reveal the epigenetic basis of d…

Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation Open

Ellen Menkhorst, Nándor Gábor Than, Udo Jeschke, Gabriela Barrientos, László Szereday , et al. · 2021

Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicat…

Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study Open

Adi L. Tarca, Andreea B. Taran, Roberto Romero, Eunjung Jung, C Paredes , et al. · 2021

Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival Open

Andrea Balogh, Lilla Reiniger, Szabolcs Hetey, Péter Király, Eszter Tóth , et al. · 2020

Zinc finger protein 554 (ZNF554), a member of the Krüppel-associated box domain zinc finger protein subfamily, is predominantly expressed in the brain and placenta in humans. Recently, we unveiled that ZNF554 regulates trophoblast invasion…

Proteomic identification of Placental Protein 1 (PP1), PP8, and PP22 and characterization of their placental expression in healthy pregnancies and in preeclampsia Open

S. Szabo, Katalin Karászi, Roberto Romero, Eszter Tóth, András Szilágyi , et al. · 2020

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta Open

Gudrun Meinhardt, Sandra Haider, Victoria Kunihs, Leila Saleh, Jürgen Pollheimer , et al. · 2020

Various pregnancy complications, such as severe forms of preeclampsia or intrauterine growth restriction, are thought to arise from failures in the differentiation of human placental trophoblasts. Progenitors of the latter either develop i…

Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype Open

Lenka Vokálová, Andrea Balogh, Eszter Tóth, Shane Vontelin van Breda, Günther Schäfer , et al. · 2020

Termed as galectin-13, placental protein 13 (PP13) is exclusively expressed in the placenta of anthropoid primates. Research on PP13 in normal and pathologic pregnancies show alteration of PP13 concentrations in pregnancy affected by preec…

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia Open

András Szilágyi, Zsolt Gelencser, Roberto Romero, Yi Xu, Péter Király , et al. · 2020

The human placenta maintains pregnancy and supports the developing fetus by providing nutrition, gas-waste exchange, hormonal regulation, and an immunological barrier from the maternal immune system. The villous syncytiotrophoblast carries…

Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study Open

Adi L. Tarca, Roberto Romero, Offer Erez, Dereje W. Gudicha, Nándor Gábor Than , et al. · 2020

Circulating early transcriptomic markers for preeclampsia can be found either by untargeted profiling of the cellular transcriptome or by focusing on placental cell-specific mRNAs. The untargeted cellular mRNA signature was consiste…

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