Nanxue Yuan
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View article: Isolating subsurface fluorescence in macroscopic lifetime imaging via high-spatial-frequency structured illumination
Isolating subsurface fluorescence in macroscopic lifetime imaging via high-spatial-frequency structured illumination Open
Macroscopic fluorescence lifetime imaging (MFLI) has emerged as a robust, non-invasive imaging technique offering quantitative insights into physiological and molecular processes within live tissues, independent of fluorophore concentratio…
View article: Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination
Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination Open
Significance Macroscopic Fluorescence Lifetime Imaging (MFLI) is a powerful, non-invasive imaging modality that offers robust, physiologically relevant contrast largely independent of fluorophore concentration, excitation intensity, and ti…
View article: Real-Time Wide-Field Fluorescence Lifetime Imaging via Single-Snapshot Acquisition for Biomedical Applications
Real-Time Wide-Field Fluorescence Lifetime Imaging via Single-Snapshot Acquisition for Biomedical Applications Open
Fluorescence lifetime imaging (FLI) is a powerful tool for investigating molecular processes, microenvironmental parameters, and molecular interactions across tissue to (sub-)cellular levels. Despite its established value in numerous biome…
View article: Design and characterization of an optical phantom for mesoscopic multimodal fluorescence lifetime imaging and optical coherence elastography
Design and characterization of an optical phantom for mesoscopic multimodal fluorescence lifetime imaging and optical coherence elastography Open
We developed a novel methodology for manufacturing multimodal, tissue-mimicking phantoms that exhibit both molecular and biomechanical contrast. This methodology leverages the immiscibility of silicone and hydrogels to create solid mesosca…
View article: Quantifying Lifetime Uncertainty in Gated-ICCD Fluorescence Lifetime Imaging
Quantifying Lifetime Uncertainty in Gated-ICCD Fluorescence Lifetime Imaging Open
Fluorescence lifetime imaging (FLI) is a versatile technique for quantifying molecular processes in biomedical applications. Wide-field FLI analyzes fluorescence temporal decays computationally, often using intensified charge-coupled devic…
View article: Enhancing Fluorescence Lifetime Parameter Estimation Accuracy with Differential Transformer Based Deep Learning Model Incorporating Pixelwise Instrument Response Function
Enhancing Fluorescence Lifetime Parameter Estimation Accuracy with Differential Transformer Based Deep Learning Model Incorporating Pixelwise Instrument Response Function Open
Fluorescence Lifetime Imaging (FLI) is a critical molecular imaging modality that provides unique information about the tissue microenvironment, which is invaluable for biomedical applications. FLI operates by acquiring and analyzing photo…
View article: Transformer-based Deep Learning Model for Fluorescence Lifetime Parameter Estimations using Pixelwise Instrument Response Function
Transformer-based Deep Learning Model for Fluorescence Lifetime Parameter Estimations using Pixelwise Instrument Response Function Open
Fluorescence lifetime imaging (FLI) is an important molecular imaging modality that can provide unique information for biomedical applications. FLI is based on acquiring and processing photon time of arrival histograms. The shape and tempo…