Explanipedia

Chronic skin damage induces small intestinal damage via IL-13-induced apoptosis Open

Rina Tanemoto, Masaaki Higashiyama, Akira Tomioka, Suguru Ito, Akinori Mizoguchi , et al. · 2024

The gut–skin axis has recently been widely recognized, and both the gut and skin have been found to affect each other through a bidirectional connection; however, the precise mechanisms remain to be elucidated. Therefore, we aimed to inves…

Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome Open

Nao Sugihara, Yoshikiyo Okada, Akira Tomioka, Suguru Ito, Rina Tanemoto , et al. · 2023

These results suggest that traditional fermented foods such as miso in Japan are valuable sources of probiotic yeast candidates, which may be useful for preventing and treating stress-induced visceral hypersensitivity.

Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids Open

Yoshihiro Akita, Masaaki Higashiyama, Chie Kurihara, Suguru Ito, Shin Nishii , et al. · 2022

Immunoglobulin G4‐related disease accompanying a small intestinal ulcer: A case Open

Yuta Yoshidome, Akinori Mizoguchi, Kazuyuki Narimatsu, Shun Takahashi, Dai Hirata , et al. · 2021

Immunoglobulin (Ig)G4‐related disease (IgG4‐RD) is a systemic condition associated with fibroinflammatory lesions and is characterized by elevated serum IgG4 levels and IgG4‐positive cell infiltration into the affected tissues. It has been…

Changes in Colonic Inflammation Related with Takayasu Arteritis during a 10-year Observation Period Open

Akinori Wada, Masaaki Higashiyama, Dai Hirata, Suguru Ito, Rina Tanemoto , et al. · 2021

Takayasu arteritis (TA) sometimes presents with colitis, which may be diagnosed as inflammatory bowel disease unclassified (IBDU) because of atypical or mixed findings of ulcerative colitis (UC) and Crohn's disease. We herein report an 18-…

Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling Open

Toshiaki Teratani, Kengo Tomita, Sachiko Toma-Fukai, Yutaro Nakamura, Toshimasa Itoh , et al. · 2020

The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ has been implicated in the pathogenesis of various human diseases including fatty liver. Although nuclear translocation of PPARγ plays an important role in PPARγ signa…

Su1186 DEOXYCHOLIC ACID ENHANCES INTESTINAL LYMPHOCYTE MIGRATION TO VASCULAR ENDOTHELIUM BY DIRECT INCREASE IN EXPRESSIONS OF ICAM-I AND VCAM-1 THROUGH SPHINGOSINE-1-PHOSPHATE RECEPTOR 2 Open

Naoki Shibuya, Masaaki Higashiyama, Shin Nishii, Akinori Mizoguchi, Kenichi Inaba , et al. · 2020

Chitinase 3‐like 1 deficiency ameliorates liver fibrosis by promoting hepatic macrophage apoptosis Open

Masaaki Higashiyama, Kengo Tomita, Nao Sugihara, Hiroyuki Nakashima, Hirotaka Furuhashi , et al. · 2019

Aim Chitinase 3‐like 1 (CHI3L1), an 18‐glycosyl hydrolase‐related molecule, is a member of the enzymatically inactive chitinase‐like protein family. Serum levels of CHI3L1 are strongly correlated with hepatic fibrosis progression during ma…

Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice Open

Toshiaki Teratani, Kengo Tomita, Hirotaka Furuhashi, Nao Sugihara, Masaaki Higashiyama , et al. · 2019

Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism and energy balance in the human body. Conversely, LPL expression is almost absent in normal adult livers. Therefore, i…

Su1775 – Artificial Sweetener Acesulfame Potassium Enhanced Lymphocyte Migration to Intestinal Microvessels by Enhancing Expression of Adhesion Molecules Through Dysbiosis Open

Yoshinori Hanawa, Masaaki Higashiyama, Nao Sugihara, Akinori Wada, Kenichi Inaba , et al. · 2019

Su1550 – Aortic Carboxypeptidase-Like Protein Promotes Hepaatocellular Carcinoma Progression in Nonalcoholic Fatty Liver Disease in Mice by Activating Canonical Wint Signaling Open

Nao Sugihara, Kengo Tomita, Hirotaka Furuhashi, Chie Kurihara, Masaaki Higashiyama , et al. · 2019

147 – Pept1 Enhanced Bacterial Peptide Transport Into Lps-Treated Colonic Epithelium and Induces Neutrophil Recruitment Open

Chikako Watanabe, Kenichi Inaba, Nao Sugihara, Akinori Wada, Yoshinori Hanawa , et al. · 2019

Su1013 – Increased Basophil Recruitment to the Colon of Ulcerative Colitis Patients and Oxazolone-Induced Mice Colitis Possibly Through Ccl2-Ccr2 Axis Open

Kenichi Inaba, Chikako Watanabe, Shin Nishii, Akinori Mizoguchi, Nao Sugihara , et al. · 2019

Crohn's Disease Accompanied with Small Intestinal Extramedullary Plasmacytoma Open

Yoshinori Hanawa, Masaaki Higashiyama, Kazuki Horiuchi, Kana Ayaki, Suguru Ito , et al. · 2019

We herein present the case of an immunocompetent 63-year-old man who had previously undergone resection of Crohn's disease (CD)-related small intestinal obstruction more than 30 years ago. He had not been receiving any medication for many …

Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats Open

Takeshi Takajo, Kengo Tomita, Hanae Tsuchihashi, Shingo Enomoto, Masaaki Tanichi , et al. · 2019

Our rat model of depression is useful for clarifying the effect of depression on IBS and suggests that depression itself, rather than specific stressors, promotes the onset of IBS. Further, we provided evidence that various psychiatric dis…

Atypical Clinical Presentation of Crohn's Disease with Superior Mesenteric Vein Obstruction and Protein-losing Enteropathy Open

Suguru Ito, Masaaki Higashiyama, Kazuki Horiuchi, Akinori Mizoguchi, Shigeyoshi Soga , et al. · 2018

We herein report a 44-year-old man suffering from systemic edema due to protein-losing enteropathy (PLE) with superior mesenteric vein (SMV) obstruction and development of collateral veins, which subsequently proved to be a chronic result …

Endoscopic drainage was effective in infectious biloma after repeated transcatheter arterial chemoembolizations and radiofrequency ablation for hepatocellular carcinoma : a case report Open

Hiroyuki Tahara, Nao Sugihara, Shigeaki Nagao, Akinori Mizoguchi, Shin Nishii , et al. · 2016

A 67-year-old woman who had been treated for intraductal papillary mucinous carcinoma with bile duct jejunum anastomosis was admitted due to fever. She had undergone three sessions of repeated transcatheter arterial chemoembolizations (TAC…

A case of protein loosing enteritis probably because of cytomegalovirus infectio Open

Nakayama Kana, Shigeaki Nagao, Kazuki Horiuchi, Chihiro Yasue, Akikiko Yoshimatsu , et al. · 2015

An 80-year-old man, who had been suffering from anorexia and upper abdominal pain since 6 months ago, was sent to our hospital suspected of protein loosing enteritis (PLE) because of the marked hypoalbuminemia and the edematous states in t…

A case of immunohistochemical false positive staining caused by incompatibility between a CD4 antibody and an autostainer. Open

Ikuo Matsuda, Nao Sugihara, Hiroshi Yunokizaki, Takashi Abe, Seiichi Hirota · 2015

Precise immunophenotyping of tumor cells by immunohistochemistry is complementary to morphological examination. It is critical for the correct histopathological diagnosis of lymphomas. In this paper, we report a case of T-cell lymphoma who…

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