Naohiko Nakamura
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View article: Inhibition of fatty acid binding protein suppresses pancreatic cancer progression and metastasis
Inhibition of fatty acid binding protein suppresses pancreatic cancer progression and metastasis Open
Obesity is a known risk factor for Pancreatic ductal adenocarcinoma (PDAC). Fatty acid binding protein 4 (FABP4) is higher in plasma of obese patients, and linked to the progression of obesity-related cancers. To provide insights into the …
View article: Inhibition of adipose tissue-derived fatty acid binding protein suppresses pancreatic cancer progression and metastasis
Inhibition of adipose tissue-derived fatty acid binding protein suppresses pancreatic cancer progression and metastasis Open
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and obesity is a known risk factor for PDAC. Fatty acid binding protein 4 (FABP4) is noted to be higher in obese patients, and linked to the progress…
View article: Interferon‐expressing oncolytic adenovirus + chemoradiation inhibited pancreatic cancer growth in a hamster model
Interferon‐expressing oncolytic adenovirus + chemoradiation inhibited pancreatic cancer growth in a hamster model Open
Past clinical trials of adjuvant therapy combined with interferon (IFN) alpha, fluorouracil, cisplatin, and radiation improved the 5‐year survival rate of pancreatic ductal adenocarcinoma (PDAC). However, these trials also revealed the dis…
View article: Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report
Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report Open
Key Clinical Message Malignant peritoneal mesothelioma, a rare and poor prognosis disease, is seldom treated surgically, especially for recurrence. However, early diagnosis and aggressive treatment of primary and recurrent tumors can achie…
View article: Prognostic factors in T4b gastric cancer after surgery: A more balanced and sequential therapy for patients?
Prognostic factors in T4b gastric cancer after surgery: A more balanced and sequential therapy for patients? Open
Introduction: This study aimed to evaluate the prognostic factors in T4b gastric cancer (GC) in order to improve future therapeutic strategies. Methods: We retrospectively analyzed the medical records of 43 patients with advanced GC who un…
View article: Infectivity-Enhanced, Conditionally Replicative Adenovirus for COX-2-Expressing Castration-Resistant Prostate Cancer
Infectivity-Enhanced, Conditionally Replicative Adenovirus for COX-2-Expressing Castration-Resistant Prostate Cancer Open
Background: The development of conditionally replicative adenoviruses (CRAds) for castration-resistant prostate cancer (CRPC), particularly neuroendocrine prostate cancer (NEPC), has two major obstacles: choice of control element and poor …
View article: Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report
Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report Open
Malignant peritoneal mesothelioma, a rare disease with a very poor prognosis, is seldom treated surgically, especially for recurrence. However, early diagnosis and aggressive treatment of primary and recurrent tumors, particularly the loca…
View article: Non-alcoholic fatty liver disease may be a risk factor for liver metastasis after radical surgery for colorectal cancer: a retrospective study
Non-alcoholic fatty liver disease may be a risk factor for liver metastasis after radical surgery for colorectal cancer: a retrospective study Open
Background The liver is the most common site for distant colorectal cancer (CRC) metastasis, which develops in approximately one-third of CRC patients who undergo radical surgery. Hepatectomy for colorectal liver metastasis (CRLM) is the o…
View article: Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery
Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery Open
More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for the development of metabolic syndrome but also for many can…
View article: Intra-tumoral FGFR2 Expression Predicts Prognosis and Chemotherapy Response in Advanced HER2-positive Gastric Cancer Patients
Intra-tumoral FGFR2 Expression Predicts Prognosis and Chemotherapy Response in Advanced HER2-positive Gastric Cancer Patients Open
Background/Aim: This study aimed to evaluate the relationship between clinical outcomes and intra-tumoral fibroblast growth factor receptor 2 (FGFR2) expression in human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC…
View article: Preoperative diagnosis of gallbladder torsion by magnetic resonance cholangiopancreatography: A case report
Preoperative diagnosis of gallbladder torsion by magnetic resonance cholangiopancreatography: A case report Open
Gallbladder torsion is a rare and potentially fatal condition presenting with acute abdominal pain. Gallbladder torsion requires early diagnosis and treatment; however, preoperative diagnosis is difficult. In the present case, magnetic res…
View article: Hyaluronic Acid May Be a Predictive Biomarker for Thrombocytopenia and Liver Dysfunction After Oxaliplatin-based Chemotherapy
Hyaluronic Acid May Be a Predictive Biomarker for Thrombocytopenia and Liver Dysfunction After Oxaliplatin-based Chemotherapy Open
Background/Aim: Following oxaliplatin-based chemotherapy, approximately half of all colorectal cancer patients develop sinusoidal obstruction syndrome (SOS). SOS can be monitored by measuring splenic volume; however, obtaining this measure…
View article: Conservative management of spontaneous isolated superior mesenteric artery dissection: A case report
Conservative management of spontaneous isolated superior mesenteric artery dissection: A case report Open
Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare and potentially fatal cause diagnosis presenting with acute abdominal; however, because of its rarity, the pathogenic factors of SISMAD remain unknown and no cle…
View article: Life prognosis of sentinel node navigation surgery for early-stage gastric cancer: Outcome of lymphatic basin dissection
Life prognosis of sentinel node navigation surgery for early-stage gastric cancer: Outcome of lymphatic basin dissection Open
The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery.
View article: nPTD classification: an updated classification of gastric cancer location for function preserving gastrectomy based on physiological lymphatic flow
nPTD classification: an updated classification of gastric cancer location for function preserving gastrectomy based on physiological lymphatic flow Open
Background The correlation between tumor location and lymphatic flow distribution in gastric cancer has been previously reported, and PTD (Proximal – Transitional – Distal) classification was proposed. Our group updated and developed the n…
View article: Conservative management of spontaneous isolated superior mesenteric artery dissection: a case report
Conservative management of spontaneous isolated superior mesenteric artery dissection: a case report Open
Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare and potentially fatal cause diagnosis presenting with acute abdominal; however, because of its rarity, the pathogenic factors of SISMAD remain unknown and no cle…
View article: Relationship between fatty liver change and nutritional status after total gastrectomy in gastric cancer patients: a retrospective study
Relationship between fatty liver change and nutritional status after total gastrectomy in gastric cancer patients: a retrospective study Open
Background The relationship between chronological nutritional changes and development of fatty liver after total gastrectomy (TG) in gastric cancer (GC) patients is still unclear. This study aimed to evaluate relationship between developme…
View article: nPTD Classification: An Updated Classification of Gastric Cancer Location for Function Preserving Gastrectomy Based on Physiological Lymphatic Flow
nPTD Classification: An Updated Classification of Gastric Cancer Location for Function Preserving Gastrectomy Based on Physiological Lymphatic Flow Open
Background: The correlation between tumor location and lymphatic flow distribution in gastric cancer has been previously reported, and PTD (Proximal – Transitional – Distal) classification, proposed. We updated and developed the nPTD class…
View article: Laparoscopic intraperitoneal mesh repair of a large incisional hernia in a kidney transplantation patient: A case report
Laparoscopic intraperitoneal mesh repair of a large incisional hernia in a kidney transplantation patient: A case report Open
A 73‐year‐old woman presented to our hospital because of painful bulging in the right lower abdomen, and developed a 17 × 12 cm incisional hernia after kidney transplantation using right oblique incision. Laparoscopic intraperitoneal onlay…
View article: Advanced gastric cancer with abdominal wall invasion treated with curative resection after chemotherapy: a case report
Advanced gastric cancer with abdominal wall invasion treated with curative resection after chemotherapy: a case report Open
View article: Risk Factors for Overall Complications and Remote Infection After Gastrectomy in Elderly Gastric Cancer Patients
Risk Factors for Overall Complications and Remote Infection After Gastrectomy in Elderly Gastric Cancer Patients Open
Preoperative anemia and intraoperative factors, including the surgical procedure, could affect the occurrence of postoperative complications in elderly patients.
View article: Relationship Between Fatty Liver Change and Nutritional Status After Total Gastrectomy in Gastric Cancer Patients: A Retrospective Study
Relationship Between Fatty Liver Change and Nutritional Status After Total Gastrectomy in Gastric Cancer Patients: A Retrospective Study Open
Background : The relationship between chronological nutritional changes and development of fatty liver after total gastrectomy (TG) in gastric cancer (GC) patients is still unclear. This study aimed to evaluate relationship between develop…
View article: Chronological Changes in Neutrophil/lymphocyte Ratio in Advanced Gastric Cancer Patients Treated with Nivolumab: a Report of Nine Cases
Chronological Changes in Neutrophil/lymphocyte Ratio in Advanced Gastric Cancer Patients Treated with Nivolumab: a Report of Nine Cases Open
We experienced nine GC cases treated with nivolumab and assessed the association between chronological NLR changes throughout chemotherapy and tumor response to nivolumab. Changes in NLR during pretreatment chemotherapy might predict tumor…
View article: Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report
Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report Open
View article: Predictive factors for developing acute cholangitis and/or cholecystitis in patients undergoing delayed cholecystectomy: A retrospective study
Predictive factors for developing acute cholangitis and/or cholecystitis in patients undergoing delayed cholecystectomy: A retrospective study Open
View article: A Case of Advanced Gastroesophageal Junction Cancer with Bulky Lymph Node Metastases Treated with Nivolumab
A Case of Advanced Gastroesophageal Junction Cancer with Bulky Lymph Node Metastases Treated with Nivolumab Open
A 71-year-old woman was diagnosed with advanced gastroesophageal junction cancer with bulky lymph nodes along the cardiac region and the lower mediastinum (GE-Circ type 3 T3 N3 M0 H0 stage III) and received treatment with S-1 and oxaliplat…
View article: Efficacy of the fat-dissociation method for nodal harvesting in gastric cancer
Efficacy of the fat-dissociation method for nodal harvesting in gastric cancer Open
Based on our results, the fat-dissociation method is effective in shortening the duration of lymph node harvest in gastric cancer surgery.
View article: Severity of postgastrectomy syndrome and quality of life after advanced gastric cancer radical gastrectomy
Severity of postgastrectomy syndrome and quality of life after advanced gastric cancer radical gastrectomy Open
It has previously been suggested that postgastrectomy syndrome (PGS) is more severe in patients after surgery for advanced gastric cancer than in patients with early gastric cancer. Using the postgastrectomy syndrome assessment scale-45 (P…
View article: Spleen Volume as a Predictive Biomarker for Thrombocytopenia and Liver Dysfunction After Oxaliplatin-based Chemotherapy
Spleen Volume as a Predictive Biomarker for Thrombocytopenia and Liver Dysfunction After Oxaliplatin-based Chemotherapy Open
SV was significantly associated with thrombocytopenia and liver dysfunction in CRC patients, and predicted SOS.
View article: Pancreatic neuroendocrine tumor featuring growth into the main pancreatic duct and tumor thrombus within the splenic vein: a case report
Pancreatic neuroendocrine tumor featuring growth into the main pancreatic duct and tumor thrombus within the splenic vein: a case report Open
A 48-year-old woman was admitted to our hospital because of upper abdominal pain. Computer tomography showed an enhancing mass in the pancreatic body, dilation of the main pancreatic duct (MPD) and a filling defect within the splenic vein.…