Naohisa Yahagi
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View article: Technical evolution in endoscopic submucosal dissection: The role of the water pressure method
Technical evolution in endoscopic submucosal dissection: The role of the water pressure method Open
The water pressure method (WPM) is an innovative technique in endoscopic submucosal dissection (ESD) that employs active waterjet pressure to expand the submucosal space in three dimensions. Rather than merely creating an underwater enviro…
View article: Predictors of local recurrence and piecemeal resection in duodenal underwater endoscopic mucosal resection
Predictors of local recurrence and piecemeal resection in duodenal underwater endoscopic mucosal resection Open
View article: Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer
Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer Open
View article: Endoscopic ultrasound classification for prediction of endoscopic submucosal dissection resectability: PREDICT classification
Endoscopic ultrasound classification for prediction of endoscopic submucosal dissection resectability: PREDICT classification Open
Background and study aims The safety of endoscopic submucosal dissection (ESD) has been reported, and the risk of lymph node metastasis is low for colorectal cancer if depth of invasion is the only non-curative factor on histological evalu…
View article: Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study
Distinctive duodenal microbiomes and bile acid profiles in duodenal tumor patients revealed by prospective observational study Open
The incidence of duodenal tumors (DTs) is increasing. However, the mechanisms underlying its development remain unclear. Environmental factors, including the microbiome and bile acids (BAs), are believed to influence tumor development. The…
View article: Novel thin endoscope enables endoscopic submucosal dissection without retroflexion for tumor involving the whole pyloric ring
Novel thin endoscope enables endoscopic submucosal dissection without retroflexion for tumor involving the whole pyloric ring Open
The narrow lumen of the pyloric ring and the duodenal bulb greatly restrict the maneuverability of an endoscope. In the forward view, the steep angle of the back side of the pyloric ring makes it difficult to approach the lesion extending …
View article: Colorectal tumor comorbidity is common in patients with duodenal tumors: Exploratory cross-sectional study
Colorectal tumor comorbidity is common in patients with duodenal tumors: Exploratory cross-sectional study Open
Background and study aims The duodenum and colorectum are target organs for familial colorectal adenomatous polyposis, however, the association of duodenal epithelial tumors (DETs) and colorectal tumors is still controversial. The aim of o…
View article: Novel therapeutic endoscope facilitates endoscopic submucosal dissection of adenocarcinoma at the esophagogastric junction
Novel therapeutic endoscope facilitates endoscopic submucosal dissection of adenocarcinoma at the esophagogastric junction Open
Endoscopic submucosal dissection (ESD) of lesions at the esophagogastric junction (EGJ) presents technical difficulties, with resection on the anal side presenting particular difficulties because of the steepness of the fornix [1]. Recentl…
View article: Automatic water irrigation synchronized with the electrosurgical unit: Bubble-free underwater endoscopic submucosal dissection
Automatic water irrigation synchronized with the electrosurgical unit: Bubble-free underwater endoscopic submucosal dissection Open
The water pressure method is a underwater ESD technique, which facilitates direct visualization of the submucosa using a water stream through the waterjet channel of an endoscope [1]. This method significantly improves endoscopic exposure …
View article: Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer
Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer Open
The dense stroma is one cause of poor efficacy of T cell-mediated immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Carbohydrate sulfotransferase 15 (CHST15) is a proteoglycan-synthetic enzyme responsible for remodeling tumor strom…
View article: Efficacy and safety of the water pressure method for endoscopic submucosal dissection in superficial pharyngeal cancer
Efficacy and safety of the water pressure method for endoscopic submucosal dissection in superficial pharyngeal cancer Open
Background and study aims Superficial pharyngeal cancers can be cured with transoral surgery (TOS), which preserves organ function and quality of life. Pharyngeal endoscopic submucosal dissection (ESD) is challenging to perform because of …
View article: Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023
Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023 Open
View article: Effectiveness of Clinical Management of COVID-19 Based on Structured Clinical Knowledge and Process Paths
Effectiveness of Clinical Management of COVID-19 Based on Structured Clinical Knowledge and Process Paths Open
This study examined the effectiveness of a systematic approach to the clinical management of COVID-19, focusing on nursing turnover. METHODS: Between 2017 and 2019, a clinical process support system based on structured clinical knowledge (…
View article: Layered closure by endoscopic hand suturing involving the muscle layer for large defect after gastric endoscopic submucosal dissection
Layered closure by endoscopic hand suturing involving the muscle layer for large defect after gastric endoscopic submucosal dissection Open
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View article: Oncologic Decision after Endoscopic Resection of Gastrointestinal Malignancies: Interdisciplinary Discussion
Oncologic Decision after Endoscopic Resection of Gastrointestinal Malignancies: Interdisciplinary Discussion Open
View article: Successful management of bile duct injury with duodenal perforation using endoscopic naso-pancreatic drainage and fully covered self-expandable metallic stent deployment
Successful management of bile duct injury with duodenal perforation using endoscopic naso-pancreatic drainage and fully covered self-expandable metallic stent deployment Open
Video 1A case of bile and pancreatic duct injury with duodenal perforation during endoscopic submucosal dissection for superficial duodenal epithelial neoplasia.
View article: Endoscopic submucosal dissection using a novel therapeutic thin gastroscope for a locally recurrent rectal tumor after endoluminal rectal surgery
Endoscopic submucosal dissection using a novel therapeutic thin gastroscope for a locally recurrent rectal tumor after endoluminal rectal surgery Open
The lower rectum is the part of the gastrointestinal tract that gains most benefit from minimally invasive treatment such as endoscopic resection, because invasive surgery results in such a significant decrease in quality of life [1]. Howe…
View article: Implementation of endoscopic submucosal dissection in Europe: survey after 10 ESD Expert Training Workshops, 2009 to 2018
Implementation of endoscopic submucosal dissection in Europe: survey after 10 ESD Expert Training Workshops, 2009 to 2018 Open
Background and aims Transfer of ESD technique for early gastrointestinal cancer from Japan requires expert-supervised experimental training before unsupervised implementation of clinical ESD. Aims To evaluate unsupervised implementation of…
View article: Intensive endoscopic resection strategy for multiple duodenal polyposis associated with familial adenomatous polyposis
Intensive endoscopic resection strategy for multiple duodenal polyposis associated with familial adenomatous polyposis Open
Background and Aim Multiple duodenal polyposis associated with familial adenomatous polyposis (FAP) is a high risk of duodenal cancer development. We evaluated the feasibility of intensive endoscopic resection that is a comprehensive treat…
View article: Novel quantitative assessment indicators for efficiency and precision of endoscopic submucosal dissection in animal training models by analyzing an electrical surgical unit
Novel quantitative assessment indicators for efficiency and precision of endoscopic submucosal dissection in animal training models by analyzing an electrical surgical unit Open
Objectives Although endoscopic submucosal dissection (ESD) training is important, quantitative assessments have not been established. This study aimed to explore a novel quantitative assessment system by analyzing an electrical surgical un…
View article: Characteristics of flat‐type ulcerative colitis‐associated neoplasia on chromoendoscopic imaging with indigo carmine dye spraying
Characteristics of flat‐type ulcerative colitis‐associated neoplasia on chromoendoscopic imaging with indigo carmine dye spraying Open
Objectives Despite recent advances in endoscopic equipment and diagnostic techniques, early detection of ulcerative colitis‐associated neoplasia (UCAN) remains difficult because of the complex background of the inflamed mucosa of ulcerativ…
View article: Effectiveness of water pressure method in colorectal endoscopic submucosal dissection by novice endoscopists
Effectiveness of water pressure method in colorectal endoscopic submucosal dissection by novice endoscopists Open
Background and study aims Colorectal endoscopic submucosal dissection (ESD) remains challenging for novice endoscopists. Not only the underwater conditions but also active use of water pressure with the water pressure method (WPM) can help…
View article: Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice
Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice Open
Limited intratumoral T‐cell infiltration in pancreatic ductal adenocarcinoma (PDAC) is an obstacle to immunotherapy, yet the efficient approach to enhance tumor‐infiltrating T cells is not fully established. Here, we show that tumor‐specif…
View article: A successful case of endoscopic submucosal dissection using the water pressure method for hypopharyngeal carcinoma with severe fibrosis
A successful case of endoscopic submucosal dissection using the water pressure method for hypopharyngeal carcinoma with severe fibrosis Open
Endoscopic submucosal dissection (ESD) is a local treatment method for pharyngeal carcinoma that can preserve organs and maintain patients' quality of life. However, it is challenging because of the narrow and three-dimensional structure, …
View article: Successful endoscopic submucosal dissection for a cecal laterally spreading tumor using a motorized spiral enteroscope in a case with difficult intubation
Successful endoscopic submucosal dissection for a cecal laterally spreading tumor using a motorized spiral enteroscope in a case with difficult intubation Open
In colorectal endoscopic submucosal dissection (ESD), it is essential to intubate with the endoscope in a straight position and maintain stable maneuverability during the procedure. It is however often difficult to obtain these good condit…
View article: Novel therapeutic thin endoscope facilitates endoscopic submucosal dissection for cervical esophageal cancer involving the pharyngoesophageal junction
Novel therapeutic thin endoscope facilitates endoscopic submucosal dissection for cervical esophageal cancer involving the pharyngoesophageal junction Open
The cervical esophagus, especially the pharyngoesophageal junction, is narrow; thus, the movement of the endoscope is severely limited [1] [2]. This region also has strong flexion to the posterior wall; thus, it is occasionally difficult t…
View article: Supplementary Tables S1-S2, Figures 1-7 from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State
Supplementary Tables S1-S2, Figures 1-7 from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State Open
Supplementary Tables S1-S2, Figures 1-7 from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State
View article: Data from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State
Data from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State Open
The mammalian SWI/SNF chromatin remodeling complex, an essential epigenetic regulator, contains either a single Brm or BRG1 molecule as its catalytic subunit. We observed frequent loss of Brm expression but not of BRG1 in human gastric can…
View article: Data from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State
Data from Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State Open
The mammalian SWI/SNF chromatin remodeling complex, an essential epigenetic regulator, contains either a single Brm or BRG1 molecule as its catalytic subunit. We observed frequent loss of Brm expression but not of BRG1 in human gastric can…