Naokado Ikeda
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View article: RADT-19. ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, A RANDOMIZED CONTROLLED TRIAL FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMAS
RADT-19. ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, A RANDOMIZED CONTROLLED TRIAL FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMAS Open
BACKGROUND High-grade meningiomas (HGMs) recurred after X-ray treatment showed pessimistic prognosis. We conducted “A phase II investigator-lead RCT using accelerator-based boron neutron capture therapy (BNCT) system for refractory recurre…
View article: Surgical Resection of a Giant De Novo Cavernous Malformation in the Cerebral Basal Ganglia: Case Report
Surgical Resection of a Giant De Novo Cavernous Malformation in the Cerebral Basal Ganglia: Case Report Open
A 74-year-old woman had a lacunar infarction in the brainstem and was admitted to Takeda General Hospital for treatment. She had significant sequelae and was discharged with a Modified Rankin Scale 0. Imaging follow-up was conducted every …
View article: Ulnar Neuropathy Caused by a Giant Epidermal Cyst at the Elbow: Case Report
Ulnar Neuropathy Caused by a Giant Epidermal Cyst at the Elbow: Case Report Open
Here, we report an unusual case of ulnar neuropathy at the elbow caused by a giant epidermal cyst. A 76-year-old man was assessed on an outpatient basis for ulnar numbness of the left hand that had persisted for 6 months. A soft, elastic s…
View article: Two reports of iatrogenic pseudoaneurysms intraoperatively induced by an ultrasonic surgical aspirator: A rare intraoperative complication
Two reports of iatrogenic pseudoaneurysms intraoperatively induced by an ultrasonic surgical aspirator: A rare intraoperative complication Open
Background: The ultrasonic surgical aspirator is widely used in intracranial tumor resection as this instrument is considered safe. The advantage of an ultrasonic surgical aspirator is that it does not damage vessels or nerves close to the…
View article: Postoperative Airway Management after Anterior Cervical Spine Surgery: Retrospective Neurosurgical Multicenter Study
Postoperative Airway Management after Anterior Cervical Spine Surgery: Retrospective Neurosurgical Multicenter Study Open
Airway complications that occur after anterior cervical spine surgery pose a life-threatening risk, which encompasses complications including prolonged intubation, unplanned reintubation, and/or necessity of tracheostomy. The present study…
View article: A Case of Symptomatic Multiple Tarlov Cysts Treated with Microsurgical Wrapping Technique -Efficacy and Limitation of Surgical Procedure-
A Case of Symptomatic Multiple Tarlov Cysts Treated with Microsurgical Wrapping Technique -Efficacy and Limitation of Surgical Procedure- Open
Tarlov cysts (TCs) rarely cause clinical symptoms, such as leg pain, buttock pain, and bladder/bowel dysfunction. Surgery is considered when these symptoms persist despite medical treatments. Among several surgical procedures, microsurgica…
View article: The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures
The Effectiveness of Vertebral Height Restoration Based on the Vertebroplasty Procedure Used to Treat Osteoporotic Vertebral Fractures Open
Objective: Whether the use of a balloon or stent in vertebroplasty for vertebral fractures, such as balloon kyphoplasty (BKP) or vertebral body stenting (VBS), actually contributes to the restoration of postoperative vertebral height is un…
View article: Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty
Treatment for Osteoporotic Vertebral Fracture - A Short Review of Orthosis and Percutaneous Vertebroplasty and Balloon Kyphoplasty Open
The management of osteoporotic vertebral fractures (OVFs) in the elderly includes nonoperative treatment and vertebroplasty, but has not been established due to the diversity of patient backgrounds. The purpose of this study was to compare…
View article: Occult neurohypophyseal germinoma discovered during the course of long-term diabetes insipidus: illustrative case
Occult neurohypophyseal germinoma discovered during the course of long-term diabetes insipidus: illustrative case Open
BACKGROUND The authors report a case of occult neurohypophyseal germinoma detected in a patient with long-term diabetes insipidus. Central diabetes insipidus is the initial symptom in 95% of cases of neurohypophyseal germinoma. In occult n…
View article: Is Intraoperative 5-ALA PDD Effective for Brain Tumors Other than Malignant Gliomas!?—5-ALA PDD and Preoperative Image Analysis in Metastatic Brain Tumors—
Is Intraoperative 5-ALA PDD Effective for Brain Tumors Other than Malignant Gliomas!?—5-ALA PDD and Preoperative Image Analysis in Metastatic Brain Tumors— Open
脳腫瘍において，5-アミノレブリン酸（ALA）を用いた光線力学的診断（photodynamic diagnosis: PDD）の有用性はすでに周知されており，2013年には摘出率向上を目的して悪性神経膠腫に対する5-ALA製剤の術前投与が保険承認された．当教室では以前より様々な脳腫瘍に対する5-ALA-PDDを施行しており，蛍光強度の評価は従来行われている術者による主観的評価（肉眼的な3段階評価）に加え，分光スペクトル解析による蛍光強度の定量的評価（蛍光輝度計による測定）を…
View article: 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy
5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy Open
View article: History, Current Status, and Emerging Issue of 5-Aminolevulinic Acid Induced Fluorescence Guided Surgery in Neurological Surgery
History, Current Status, and Emerging Issue of 5-Aminolevulinic Acid Induced Fluorescence Guided Surgery in Neurological Surgery Open
悪性脳腫瘍に対する5-アミノレブリン酸(5-Aminolevulinic Acid: 5-ALA)を用いた蛍光ガイド手術は主に励起光源および観察用フィルターを内蔵した顕微鏡を用いて行われてきた.近年,5-ALAによる蛍光観察可能な内視鏡・サージカルルーペさらには外視鏡が登場し,その有用性が示唆されている.しかし,蛍光評価は長年蓄積された顕微鏡下評価を基盤にしており,新たな観察システムによる蛍光評価はこれらと異なる可能性があり注意が必要である.また,新たな蛍光観察システム導入…
View article: Chronic expanding pituitary hematoma with calcification resulting from pituitary adenoma: illustrative case
Chronic expanding pituitary hematoma with calcification resulting from pituitary adenoma: illustrative case Open
BACKGROUND Pituitary apoplexy (PA) is characterized by sudden headache, vomiting, visual dysfunction, anterior lobe dysfunction, and endocrine disorder due to bleeding or infarction from a pituitary adenoma. PA occurs in approximately 0.6–…
View article: Influence of surgical position and registration methods on clinical accuracy of navigation systems in brain tumor surgery
Influence of surgical position and registration methods on clinical accuracy of navigation systems in brain tumor surgery Open
The aim of this study was to evaluate the influence of skin distortion due to surgical positioning on the clinical accuracy of the navigation system. The distance errors were measured in four fiducial markers (anterior, posterior, right, a…
View article: Usefulness of Step-by-Step Anterior Clinoidectomy for Neck Clipping of Paraclinoid Aneurysms
Usefulness of Step-by-Step Anterior Clinoidectomy for Neck Clipping of Paraclinoid Aneurysms Open
前床突起は蝶形骨縁の内側端に位置し，外側からは蝶形骨縁，尾側からは視束管の一部であるoptic strutに支えられている．内頚動脈瘤頚部クリッピング術において前床突起削除は，内頚動脈近位部の確保や広い術野を得るために有用な手技である．微小解剖学的知識に基づいた段階的前床突起削除を行うことで，視神経や内頚動脈への熱損傷および機械的損傷を回避することができる．本稿では，われわれが行っている傍鞍部動脈瘤の頚部クリッピングにおける硬膜外前床突起の段階的削除法について紹介する．段階…
View article: Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells
Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells Open
ALA-PDT may be clinically effective against HGG by targeting GSCs, including MES-GSCs.
View article: Boron Compounds for Neutron Capture Therapy in the Treatment of Brain Tumors
Boron Compounds for Neutron Capture Therapy in the Treatment of Brain Tumors Open
Boron neutron capture therapy (BNCT), which uses the capture reaction between neutrons and boron-10, an isotope of boron, is rapidly gaining interest. The reason for this is the successful development of a compact accelerator-type neutron …
View article: Regression of retro-odontoid pseudotumor following botulinum injection into cervical muscles
Regression of retro-odontoid pseudotumor following botulinum injection into cervical muscles Open
Background: Posterior fixation of C1/2 has become more commonly performed to treat retro-odontoid pseudotumor (ROP). Here, we report a 60-year-old female with cervical dystonia (CD), whose ROP regressed and whose quadriparesis improved aft…
View article: Corrigendum: Evaluation of the Effectiveness of the Tap Test by Combining the Use of Functional Gait Assessment and Global Rating of Change
Corrigendum: Evaluation of the Effectiveness of the Tap Test by Combining the Use of Functional Gait Assessment and Global Rating of Change Open
[This corrects the article DOI: 10.3389/fneur.2022.846429.].
View article: Anatomical Limitation of Posterior Spinal Myelotomy for Intramedullary Hemorrhage Associated with Ependymoma or Cavernous Malformation of the High Cervical Spine
Anatomical Limitation of Posterior Spinal Myelotomy for Intramedullary Hemorrhage Associated with Ependymoma or Cavernous Malformation of the High Cervical Spine Open
Spinal intramedullary tumors such as ependymoma or vascular lesions such as cavernous malformation are often at risk of intramedullary hemorrhage. Surgical procedures involving the high cervical spinal cord are often challenging. This tech…
View article: Evaluation of the Effectiveness of the Tap Test by Combining the Use of Functional Gait Assessment and Global Rating of Change
Evaluation of the Effectiveness of the Tap Test by Combining the Use of Functional Gait Assessment and Global Rating of Change Open
Background Although the tap test for patients with suspected idiopathic normal pressure hydrocephalus (iNPH) is still often performed as part of the preoperative evaluation, it is true that some studies have reported the limitations of the…
View article: Characteristic and Management of Symptomatic Septum Pellucidum Cyst in Extreme Elderly Patient: Case Report and Literature Review
Characteristic and Management of Symptomatic Septum Pellucidum Cyst in Extreme Elderly Patient: Case Report and Literature Review Open
Septum pellucidum cyst is rare and is defined as a fluid-filled space between the lateral ventricles; it has a width of 10 mm or more. In this case report, a surgical patient of symptomatic septum pellucidum cyst (SPC) in extreme age is de…
View article: Frameless Stereotactic Biopsy with Intraoperative Computed Tomography "Assessment of Efficacy and Real Target Registration Error"
Frameless Stereotactic Biopsy with Intraoperative Computed Tomography "Assessment of Efficacy and Real Target Registration Error" Open
Frameless stereotactic brain biopsy (FSB) with navigation system has been widely used. We reported preliminary experience of FSB with intraoperative computed tomography (iCT) and examined the usefulness of this novel adjuvant technique and…
View article: Bilateral Posterolateral Sulcus Approach for the Removal of Spinal Intramedullary Metastatic Adenocarcinoma: A Technical Case Report
Bilateral Posterolateral Sulcus Approach for the Removal of Spinal Intramedullary Metastatic Adenocarcinoma: A Technical Case Report Open
Spinal intramedullary metastasis is an extremely rare event that occurs in advanced cancer. The surgical indications for spinal intramedullary metastasis are highly limited because of surgical difficulty and poor prognosis. In this technic…
View article: Usefulness of intraoperative PDD under 5-ALA administration in brain tumors
Usefulness of intraoperative PDD under 5-ALA administration in brain tumors Open
View article: Treatment and Pathophysiology of Clinoidal Meningiomas
Treatment and Pathophysiology of Clinoidal Meningiomas Open
トルコ鞍近傍を発生母地とする髄膜腫の総称が傍鞍部髄膜腫であり, そのうち本稿では傍鞍部に発生する前床突起部髄膜腫について論じる.
View article: ET-9 Development of photosensitive antibodies for near-infrared light immunotherapy targeting EGFR and IL13Rα2 of malignant gliomas and investigation of their photodynamic cytotoxic activity in vitro
ET-9 Development of photosensitive antibodies for near-infrared light immunotherapy targeting EGFR and IL13Rα2 of malignant gliomas and investigation of their photodynamic cytotoxic activity in vitro Open
Introduction: Near-Infrared Photoimmunotherapy (NIR-PIT) is a recently developed hybrid cancer therapy based on photodynamic cytotoxicity and anti-tumor immunopotentiation, utilizing a photosensitive antibody drug (PSAD). A global Phase II…
View article: Development of novel Mixed Reality-Based Simulator for Endoscopic Transnasal Surgery with HoloLens and multiple AR tracker
Development of novel Mixed Reality-Based Simulator for Endoscopic Transnasal Surgery with HoloLens and multiple AR tracker Open
Background Virtual reality (VR) and mixed reality (MR) are now widely applied for preoperative simulation and intraoperative navigation. Methods We developed an MR-based simulator for endoscopic transnasal surgery (ETNS) with a head-mounte…
View article: Recent Updates in Neurosurgical Interventions for Spontaneous Intracerebral Hemorrhage: Minimally Invasive Surgery to Improve Surgical Performance
Recent Updates in Neurosurgical Interventions for Spontaneous Intracerebral Hemorrhage: Minimally Invasive Surgery to Improve Surgical Performance Open
The efficacy and safety of surgical treatment for intracerebral hemorrhage (ICH) have long been subjects of investigation and debate. The recent results of the minimally invasive surgery plus alteplase for intracerebral hemorrhage evacuati…
View article: A case of nonapoplectic pituitary adenoma presenting with isolated oculomotor nerve palsy
A case of nonapoplectic pituitary adenoma presenting with isolated oculomotor nerve palsy Open
We report a rare case of nonapoplectic pituitary adenoma that did not invade the cavernous sinus and was associated with isolated oculomotor nerve palsy. A 61-year-old male was admitted to our hospital due to diplopia that had gradually wo…