Naoki Shijubou
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View article: The size of CD8+ infiltrating T cells is a prognostic marker for esophageal squamous cell carcinoma
The size of CD8+ infiltrating T cells is a prognostic marker for esophageal squamous cell carcinoma Open
View article: MHC class I trafficking signal improves induction of cytotoxic T lymphocyte using artificial antigen presenting cells
MHC class I trafficking signal improves induction of cytotoxic T lymphocyte using artificial antigen presenting cells Open
View article: Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis
Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis Open
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including t…
View article: Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization
Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization Open
Adoptive T cell therapy, using T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells, is a potent immunotherapy option. Bladder cancer is a prevalent urological malignancy, particularly in cases of muscle…
View article: 1406 Loss of a squamous cell carcinoma lineage marker deltaNp63 has a role in immune escape in lung cancer
1406 Loss of a squamous cell carcinoma lineage marker deltaNp63 has a role in immune escape in lung cancer Open
View article: Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer
Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer Open
Background The efficacy of anti‐CTLA‐4 antibody (ipilimumab) plus anti‐programmed cell death 1 antibody (nivolumab) in treating advanced non‐small cell lung cancer (NSCLC) is impeded by an elevated risk of severe immune‐related adverse eve…
View article: Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors
Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors Open
Purpose Although immune checkpoint inhibitors (ICIs), together with cytotoxic chemotherapy (chemoimmunotherapy), have been adapted for the initial treatment of extensive-disease small-cell lung cancer (ED-SCLC), they have achieved limited …
View article: Targeting Mhc Class 1 Vesicle Improve Induction of Cytotoxic T Lymphocyte Using Artificial Antigen Presenting Cells
Targeting Mhc Class 1 Vesicle Improve Induction of Cytotoxic T Lymphocyte Using Artificial Antigen Presenting Cells Open
View article: Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity?
Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity? Open
Immune checkpoint inhibitors (ICIs) for various types of malignancy, including non-small-cell lung cancer, have improved prognosis in some cases. Granuloma formation after ICI administration suggests a tumor antigen-specific cytotoxic T ce…
View article: Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity?
Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity? Open
Immune checkpoint inhibitors (ICIs) for various types of malignancy, including non-small-cell lung cancer, have improved prognosis in some cases. Granuloma formation after ICI administration suggests a tumor antigen-specific cytotoxic T ce…
View article: Autoimmune Pulmonary Alveolar Proteinosis during the Treatment of Idiopathic Inflammatory Myopathy
Autoimmune Pulmonary Alveolar Proteinosis during the Treatment of Idiopathic Inflammatory Myopathy Open
Approximately 50% of idiopathic inflammatory myopathies (IIMs) are associated with interstitial lung disease (ILD). Typically, IIM-ILD manifests as nonspecific interstitial pneumonia. We herein report a rare case of a 78-year-old man with …
View article: Association of tumor burden with severe immune-related adverse events in nivolumab plus ipilimumab therapy for non-small cell lung cancer
Association of tumor burden with severe immune-related adverse events in nivolumab plus ipilimumab therapy for non-small cell lung cancer Open
Ipilimumab and nivolumab improve the prognosis of patients with non-small cell lung cancer (NSCLC), albeit with a higher incidence of immune-related adverse events (irAEs) than immune checkpoint inhibitor (ICI) monotherapy. In this study, …
View article: A Case of Immune-related Renal Failure in Response to Chemo-immunotherapy Combinations That Was Successfully Treated with Steroid Therapy and Temporary Hemodialysis
A Case of Immune-related Renal Failure in Response to Chemo-immunotherapy Combinations That Was Successfully Treated with Steroid Therapy and Temporary Hemodialysis Open
背景.免疫チェックポイント阻害薬は非小細胞肺癌の標準治療の一つで有害事象の管理が重要である.免疫関連腎障害の多くはステロイドへの反応は良好だが一部にステロイド抵抗性を認め腎機能障害の遷延は予後悪化と関連する.ステロイド抵抗性時の追加治療は定まっていない.症例.72歳男性 肺扁平上皮癌cT3N2M0 stage IIIBと診断し初回治療でカルボプラチン,ナブパクリタキセルおよびペムブロリズマブを開始し最良効果は部分奏効だった.3コース目施行時に2型糖尿病が悪化し精査入院した.…
View article: Immunological and nutritional predictive factors in patients receiving pembrolizumab for the first-line treatment of non-small cell lung cancer
Immunological and nutritional predictive factors in patients receiving pembrolizumab for the first-line treatment of non-small cell lung cancer Open
View article: Alveolar Hemorrhage Caused by the Combination of Immune Checkpoint Inhibitors (ICIs) and Angiogenesis Inhibitors: The Underlying Long-Term Vascular Endothelial Growth Factor (VEGF) Inhibition
Alveolar Hemorrhage Caused by the Combination of Immune Checkpoint Inhibitors (ICIs) and Angiogenesis Inhibitors: The Underlying Long-Term Vascular Endothelial Growth Factor (VEGF) Inhibition Open
The combination of immune checkpoint inhibitors (ICIs) and other anticancer agents is the standard of care for various cancers. Bevacizumab, an anti-angiogenesis inhibitor, causes serious adverse events such as pulmonary hemorrhage (PH). H…
View article: Pseudocirrhosis due to liver metastasis from lung adenocarcinoma
Pseudocirrhosis due to liver metastasis from lung adenocarcinoma Open
Pseudocirrhosis is a radiological diagnosis of cirrhosis without histological evidence and occurs as a complication of liver metastases from solid tumors. A 50‐year‐old man without any previous history of liver disease was diagnosed with a…
View article: Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy: A case report
Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy: A case report Open
We urge clinicians to consider Entamoeba histolytica infection if severe colitis progresses after steroid therapy. Preemptive treatment is recommended then.
View article: Long‐term response to osimertinib in elderly patients with lung adenocarcinoma harbouring de novo <scp><i>EGFR</i> T790M</scp>: a case report and literature review
Long‐term response to osimertinib in elderly patients with lung adenocarcinoma harbouring de novo <span><i>EGFR</i> T790M</span>: a case report and literature review Open
Osimertinib is a potent and irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that selectively acts on both EGFR‐sensitive and EGFR T790M‐resistant mutations. Patients with pre‐treatment EGFR T790M mutati…
View article: Diffuse alveolar haemorrhage due to pheochromocytoma crisis
Diffuse alveolar haemorrhage due to pheochromocytoma crisis Open
Key message Clinicians should be aware that interstitial shadows with extreme hypertension should be considered as indicators for diffuse alveolar haemorrhage due to pheochromocytoma crisis.
View article: Guillain-Barré Syndrome Developed as a Neurological Immune-related Adverse Event After Response to Combination Chemo-immunotherapy
Guillain-Barré Syndrome Developed as a Neurological Immune-related Adverse Event After Response to Combination Chemo-immunotherapy Open
背景．免疫チェックポイント阻害薬（immune checkpoint inhibitors：ICI）は非小細胞肺癌の標準治療で，様々な免疫関連有害事象の報告がある．免疫関連神経障害（neurological immune-related adverse event：nAE）は稀で，報告例は少ない．症例．64歳男性．肺腺癌cT3N3M0，Stage IIICと診断し，初回治療でシスプラチン，ペメトレキセドおよびペムブロリズマブを開始した．最良効果は部分奏効で，ペメトレキセドお…
View article: Long‐term response to afatinib in an elderly patient with uncommon epidermal growth factor receptor mutation‐positive lung adenocarcinoma
Long‐term response to afatinib in an elderly patient with uncommon epidermal growth factor receptor mutation‐positive lung adenocarcinoma Open
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are the standard treatment for patients with non‐small cell lung cancer (NSCLC) harboring EGFR mutations. Uncommon mutations, excluding exon 19 deletions and exon 21 L858R,…
View article: Spontaneous pneumothorax during nintedanib therapy in patients with systemic sclerosis‐associated interstitial lung disease
Spontaneous pneumothorax during nintedanib therapy in patients with systemic sclerosis‐associated interstitial lung disease Open
Interstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc). Nintedanib, an antifibrotic drug, has recently been approved for treating SSc‐ILD. Although there have been no reports suggesting the development of pneu…
View article: Lung adenocarcinoma with tumor resolution and dystrophic calcification after salvage surgery following immune checkpoint inhibitor therapy: A case report
Lung adenocarcinoma with tumor resolution and dystrophic calcification after salvage surgery following immune checkpoint inhibitor therapy: A case report Open
A clinical trial of immune checkpoint inhibitors for advanced non‐small cell lung cancer reported an overall survival plateau with a long tail to the survival curve, suggesting that immune checkpoint inhibitors prolong survival. However, l…
View article: A Case of Lung Squamous Cell Carcinoma with Alveolar Hemorrhaging After a Long-term Response to Pembrolizumab
A Case of Lung Squamous Cell Carcinoma with Alveolar Hemorrhaging After a Long-term Response to Pembrolizumab Open
背景．免疫チェックポイント阻害薬であるペムブロリズマブは非小細胞肺癌に対する標準治療として用いられているが，免疫チェックポイント阻害薬使用による肺障害（checkpoint inhibitor pneumonitis：CIP）の報告が散見される．症例．78歳，男性．全身CTで左舌区に腫瘤影を認めた．精査の結果，肺扁平上皮癌cT2aN2M1a，Stage IVA，PD-L1 tumor proportion score 5%と診断し，初回治療としてカルボプラチン＋ナブパクリタ…
View article: Lung adenocarcinoma observed within a peripheral cavitary lesion using an ultrathin bronchoscope
Lung adenocarcinoma observed within a peripheral cavitary lesion using an ultrathin bronchoscope Open