Naoko Hattori
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View article: EXTH-58. Long-term treatment with mutant IDH inhibitor DS-1001b suppresses tumor growth and induces epigenetic reprogramming in IDH1-mutant gliomas
EXTH-58. Long-term treatment with mutant IDH inhibitor DS-1001b suppresses tumor growth and induces epigenetic reprogramming in IDH1-mutant gliomas Open
BACKGROUND Heterozygous mutations in isocitrate dehydrogenase (IDH) 1 and 2 represent defining molecular alterations in astrocytoma, IDH-mutant, and oligodendroglioma, IDH-mutant, as classified by the World Health Organization Classificati…
View article: Emerging Multi-Source Transmission of SFTS Virus on a Remote Japanese Island: A One-Health Perspective
Emerging Multi-Source Transmission of SFTS Virus on a Remote Japanese Island: A One-Health Perspective Open
Tick-borne viral infections, including Severe Fever with Thrombocytopenia Syndrome (SFTS), pose a growing global public health threat owing to their potential for rapid spread and high mortality rates. We report a localized outbreak of SFT…
View article: Epigenomic Alterations Induced by Environmental Factors and Their Roles in Disease Development
Epigenomic Alterations Induced by Environmental Factors and Their Roles in Disease Development Open
View article: Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value
Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value Open
Liposarcoma (LPS) is the most common soft-tissue sarcoma in adults, and well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are the most frequent subtypes. These LPSs are considered to develop due to disturbanc…
View article: Large-scale epidemiological survey on the actual situation and latent morbidity of tinea pedis and tinea unguium (Foot Check 2023)- Second report:
Large-scale epidemiological survey on the actual situation and latent morbidity of tinea pedis and tinea unguium (Foot Check 2023)- Second report: Open
View article: Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma
Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma Open
Dedifferentiated liposarcoma (DDLPS) comprises a high-grade dedifferentiated (DD) component and a juxtaposed well-differentiated (WD) component. The DD component is believed to originate from the WD component by acquiring additional genomi…
View article: Population Pharmacokinetics of Tamibarotene in Pediatric and Young Adult Patients with Recurrent or Refractory Solid Tumors
Population Pharmacokinetics of Tamibarotene in Pediatric and Young Adult Patients with Recurrent or Refractory Solid Tumors Open
Tamibarotene is a synthetic retinoid that inhibits tumor cell proliferation and promotes differentiation. We previously reported on the safety and tolerability of tamibarotene in patients with recurrent or refractory solid tumors. Therefor…
View article: Intrinsic signaling pathways modulate targeted protein degradation
Intrinsic signaling pathways modulate targeted protein degradation Open
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the ant…
View article: Large-scale epidemiological survey on the actual situation and latent morbidity of tinea pedis and tinea unguium (Foot Check 2023)
Large-scale epidemiological survey on the actual situation and latent morbidity of tinea pedis and tinea unguium (Foot Check 2023) Open
本邦における足に生じる疾患,特に足・爪白癬の潜在罹患率を把握する目的で日本臨床皮膚科医会が2007年に実施した「足白癬・爪白癬の実態と潜在罹患率の大規模疫学調査(Foot Check 2007)」から16年が経過し,その間に新たな爪白癬治療外用薬や経口抗真菌薬が承認され,足白癬・爪白癬に関する啓発活動も行われてきた.しかしながら現在まで,足白癬・爪白癬の潜在罹患率に関する大規模な疫学調査は行われておらず,その実態を十分に把握できていなかった.そこで日本臨床皮膚科医会として,…
View article: Early Separation and Parallel Clonal Selection of Dedifferentiated and Well-Differentiated Components in Dedifferentiated Liposarcoma
Early Separation and Parallel Clonal Selection of Dedifferentiated and Well-Differentiated Components in Dedifferentiated Liposarcoma Open
View article: Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development
Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development Open
View article: Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples
Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples Open
Precise analysis of tissue DNA and RNA samples is often hampered by contaminating non-target cells whose amounts are highly variable. DNA methylation profiles are specific to cell types, and can be utilized for assessment of the fraction o…
View article: P1233: TUMOR PREVENTION USING DNA DEMETHYLATING AGENTS ON VIRUS-DERIVED CARCINOGENESIS IN MICE.
P1233: TUMOR PREVENTION USING DNA DEMETHYLATING AGENTS ON VIRUS-DERIVED CARCINOGENESIS IN MICE. Open
Topic: 20. Lymphoma Biology & Translational Research Background: About 12-20% of human cancers are thought to be caused by viral infections. Human T-lymphotropic virus 1 (HTLV-1) is a cause of adult T-cell leukemia/lymphoma (ATL). ATL was …
View article: P1236: REGULATION OF DNA AND HISTONE METHYLATION THROUGH METHIONINE METABOLISM IN ATL LEUKEMOGENESIS
P1236: REGULATION OF DNA AND HISTONE METHYLATION THROUGH METHIONINE METABOLISM IN ATL LEUKEMOGENESIS Open
Topic: 20. Lymphoma Biology & Translational Research Background: Adult T-cell leukemia/ lymphoma (ATL) is derived from mature T-cells transformed by human T-cell lymphotropic virus type 1 (HTLV-1). It takes several decades for carriers to …
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S2. Volcano-plots showing female/male ratio of the average CCCGGG-methylation signal of each probe for sex chromosomes X (A), Y (B), and autosomes (C) in the SM samples; Distribution of the proport…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S1. Workflow for characterization of GC metastasis biomarkers.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Materials and Methods. Primer sequences, PCR condition, bisulfite-sequencing, tissue microarray, immunohistochemical staining.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S4. Methylation levels of GFRA1, SRF, and ZNF382 by DHPLC are confirmed by MethyLight and inversely correlated with their transcription levels. (A) Correlation between DNA methylation levels measured by DHPLC an…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S2. Volcano-plots showing female/male ratio of the average CCCGGG-methylation signal of each probe for sex chromosomes X (A), Y (B), and autosomes (C) in the SM samples; Distribution of the proport…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S1. Clinicopathological information of 8 patients with GCs used in methylome analysis.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S3. DHPLC chromatograms and bisulfite-sequencing of 12 GC-related gene methylation changes.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S5. IHC images of GCs and SMs in the GFRA1, SRF, and ZNF382 immunostaining.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S2. List of CpG islands of the 73 candidate genes selected for methylation analysis by DHPLC.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S3. DHPLC chromatograms and bisulfite-sequencing of 12 GC-related gene methylation changes.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S4. Methylation levels of GFRA1, SRF, and ZNF382 by DHPLC are confirmed by MethyLight and inversely correlated with their transcription levels. (A) Correlation between DNA methylation levels measured by DHPLC an…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S1. Clinicopathological information of 8 patients with GCs used in methylome analysis.
View article: Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Purpose: Metastasis is the leading cause of death for gastric carcinoma. An epigenetic biomarker panel for predicting gastric carcinoma metastasis could have significant clinical impact on the care of patients with gastric carcinoma…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S1. Workflow for characterization of GC metastasis biomarkers.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Materials and Methods. Primer sequences, PCR condition, bisulfite-sequencing, tissue microarray, immunohistochemical staining.
View article: Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Purpose: Metastasis is the leading cause of death for gastric carcinoma. An epigenetic biomarker panel for predicting gastric carcinoma metastasis could have significant clinical impact on the care of patients with gastric carcinoma…