Naoko Nakamura
YOU?
Author Swipe
View article: CORRIGENDUM: JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure
CORRIGENDUM: JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure Open
View article: ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether
ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether Open
Decellularized tissues are used as biomaterials for transplantation. Many decellularized tissues in clinical applications are prepared using surfactants; however, we have developed a new decellularization method that uses subcritical dimet…
View article: JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure
JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure Open
View article: First-in-human clinical study of an embryonic stem cell product for urea cycle disorders
First-in-human clinical study of an embryonic stem cell product for urea cycle disorders Open
Background This study assesses the safety and efficacy of hepatocyte-like cell (HLC) infusion therapy derived from human embryonic stem cells as bridging therapy for neonatal-onset urea cycle disorders (UCD). The research includes both pre…
View article: Effects of Goreisan in the Perioperative Period of Subthalamic Deep Brain Stimulation in Parkinson's Disease
Effects of Goreisan in the Perioperative Period of Subthalamic Deep Brain Stimulation in Parkinson's Disease Open
Introduction Patients with Parkinson's disease (PD) may benefit from deep brain stimulation (DBS). Perifocal brain edema sometimes occurs after DBS surgery, but it is transient and does not affect the final prognosis. Transient deteriorati…
View article: Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials
Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials Open
View article: Pulvinar quantitative susceptibility mapping predicts visual hallucinations post‐deep brain stimulation in Parkinson's disease
Pulvinar quantitative susceptibility mapping predicts visual hallucinations post‐deep brain stimulation in Parkinson's disease Open
Purpose We have reported the relationship between low pulvinar nuclei (PN) intensity in susceptibility‐weighted imaging and the appearance of visual hallucinations and cognitive function. The aim of the study was to examine the changes in …
View article: Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients
Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients Open
Objective The severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified…
View article: Association between behavioral and psychological symptoms and cerebral small vessel disease MRI findings in memory clinic patients
Association between behavioral and psychological symptoms and cerebral small vessel disease MRI findings in memory clinic patients Open
Objectives Cerebral small vessel disease (SVD) is commonly observed among elderly individuals with cognitive impairment and has been recognized as a vascular contributor to dementia and behavioral and psychological symptoms (BPS), however,…
View article: In Vitro Evaluation of Paclitaxel-Loaded Carbon Nanotubes as Delivery Strategy Against Breast Cancer
In Vitro Evaluation of Paclitaxel-Loaded Carbon Nanotubes as Delivery Strategy Against Breast Cancer Open
View article: Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions
Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions Open
Liposome surface coating has been studied to avoid the immunological responses caused by the complement system, and alternative materials to poly(ethylene glycol) (PEG) have been explored recently since the production of anti-PEG IgM antib…
View article: Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium
Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium Open
The periodontium supports the teeth by dentoalveolar fibrous joints that serve unique oral functions. Endogenous regeneration of the periodontium around artificial teeth (dental implants) provides a cost-effective solution for the extensio…
View article: In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration
In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration Open
Recent applications of decellularized tissues have included the ectopic use of their sheets and powders for three-dimensional (3D) tissue reconstruction. Decellularized tissues are fabricated with the desired functions to employ them to a …
View article: Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy
Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy Open
Background The prevalence of cerebral microbleeds (CMBs) is significantly higher in patients with atrial fibrillation (AF) than in those without AF. CMBs in patients with AF have been reported to be primarily of the lobar type, but the exa…
View article: Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions
Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions Open
Liposome surface coating has been studied to avoid the immunological responses caused by the complement system, and alternative materials to poly(ethylene glycol) (PEG) have been explored recently since the production of anti-PEG IgM antib…
View article: Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions
Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions Open
Liposome surface coating has been studied to avoid the immunological responses caused by the complement system, and alternative materials to poly(ethylene glycol) (PEG) have been explored recently since the production of anti-PEG IgM antib…
View article: Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy
Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy Open
Background: The prevalence of cerebral microbleeds (CMBs) is significantly higher in patients with atrial fibrillation (AF) than in those without AF. CMBs in patients with AF have been reported to be primarily of the lobar type, but the ex…
View article: Tumor growth suppression by implantation of an anti-CD25 antibody-immobilized material near the tumor via regulatory T cell capture
Tumor growth suppression by implantation of an anti-CD25 antibody-immobilized material near the tumor via regulatory T cell capture Open
In this study, we designed and synthesized an implantable anti-CD25 antibody-immobilized polyethylene (CD25-PE) mesh to suppress tumor growth by removing regulatory T cells (Tregs). The PE mesh was graft-polymerized with poly(acrylic acid)…
View article: Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior
Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior Open
Due to an increasing number of cardiovascular diseases, artificial heart valves and blood vessels have been developed. Although cardiovascular applications using decellularized tissue have been studied, the mechanisms of their functionalit…
View article: Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior
Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior Open
As the number of cardiovascular diseases increases, artificial heart valves and blood vessels have been developed. Although cardiovascular application using decellularized tissue have been studied, the mechanism of their functionality is s…
View article: Elastic Modulus of ECM Hydrogels Derived from Decellularized Tissue Affects Capillary Network Formation in Endothelial Cells
Elastic Modulus of ECM Hydrogels Derived from Decellularized Tissue Affects Capillary Network Formation in Endothelial Cells Open
Recent applications of decellularized tissue have included the use of hydrogels for injectable materials and three-dimensional (3D) bioprinting bioink for tissue regeneration. Microvascular formation is required for the delivery of oxygen …
View article: Preparation of gradient-type biological tissue–polymer complex for interlinking device
Preparation of gradient-type biological tissue–polymer complex for interlinking device Open
The aim of this study was to investigate the monomer absorption behavior of decellularized dermis and prepare a gradient-type decellularized dermis-polymer complex. Decellularized dermis was prepared using sodium dodecyl sulfate, and its m…
View article: Report of Workshop to Think About the Death Pronouncement in Group Practice; How to Behave when the Unknown Doctor Pronounce the Patient's Death
Report of Workshop to Think About the Death Pronouncement in Group Practice; How to Behave when the Unknown Doctor Pronounce the Patient's Death Open
病院でも在宅でも当直・当番医といった初対面の医師が死亡確認を行うことがある．この場合，家族にとってどんな声かけや態度が望ましいのかは個別性の高い課題である．今回，グループ診療を実践している当センターの医師を対象に，この課題と向き合うワークショップ（以下，WS）を開催した．疑似経験や他者との対話を主体とした本WSは，各参加者が死亡確認のあり方を省察し，よりよい看取りを考える場になったと考えられる．
View article: Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability
Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability Open
Microencapsulation of islets can protect against immune reactions from the host immune system after transplantation. However, sufficient numbers of islets cannot be transplanted due to the increase of the size and total volume. Therefore, …
View article: Low Pulvinar Intensity in Susceptibility-Weighted Imaging May Suggest Cognitive Worsening After Deep Brain Stimulation Therapy in Patients With Parkinson's Disease
Low Pulvinar Intensity in Susceptibility-Weighted Imaging May Suggest Cognitive Worsening After Deep Brain Stimulation Therapy in Patients With Parkinson's Disease Open
Purpose: Deep brain stimulation (DBS) is an established therapy for Parkinson's disease (PD). However, deteriorating cognitive function after DBS is a considerable problem for affected patients. This study was undertaken to assess w…
View article: Extracellular Matrix Induces Periodontal Ligament Reconstruction In Vivo
Extracellular Matrix Induces Periodontal Ligament Reconstruction In Vivo Open
One of the problems in dental implant treatment is the lack of periodontal ligament (PDL), which supports teeth, prevents infection, and transduces sensations such as chewiness. The objective of the present study was to develop a decellula…
View article: Comparison of High‐Hydrostatic‐Pressure Decellularized Versus Freeze‐Thawed Porcine Menisci
Comparison of High‐Hydrostatic‐Pressure Decellularized Versus Freeze‐Thawed Porcine Menisci Open
The meniscus functions as a load distributor and secondary stabilizer in the knee, and the loss of the meniscus increases the risk of osteoarthritis. Freeze‐thawed menisci are used in clinical practice to replace defective menisci; however…
View article: Issue Information
Issue Information Open
View article: Water absorption by decellularized dermis
Water absorption by decellularized dermis Open
View article: Medical Application of Decellularized Tissue-Polymer Complex
Medical Application of Decellularized Tissue-Polymer Complex Open
生体組織から細胞成分を除去した細胞外マトリックスである脱細胞化組織は，組織再生のための移植材料として広く利用されている．筆者らは高分子材料複合化による脱細胞化組織の新規応用を目指している．本報では，まず脱細胞化組織の応用の基礎事項である調製法，構造や力学特性についてまとめた．次に，脱細胞組織の組織再生に関して，移植部位に適した組織が再生される場合が多いが，一方で異所性移植では脱細胞化組織の由来となった組織が再構築される場合もある．それぞれの報告を紹介し，組織再生の終着点の違…