Naosuke Nonoguchi
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View article: Posterolateral Sulcus Approach for Intramedullary Hemorrhage Associated With Cavernous Malformation of High Cervical Spine: Operative Technique and Outcomes
Posterolateral Sulcus Approach for Intramedullary Hemorrhage Associated With Cavernous Malformation of High Cervical Spine: Operative Technique and Outcomes Open
Objective: Intramedullary hemorrhage (IH) associated with cavernous malformation (CM) of the high cervical spine remains a significant challenge for neurosurgeons. This study aimed to evaluate the efficacy and safety of the posterolateral …
View article: Endovascular coil embolization for cerebral aneurysms in the elderly in an aging society
Endovascular coil embolization for cerebral aneurysms in the elderly in an aging society Open
Objective An aging or aged society is and has been a reality in many developed countries. Additionally, the incidence of subarachnoid hemorrhage (SAH) in elderly patients has been estimated to be increasing. However, the outcomes of SAH tr…
View article: Intelligent Ultrasonic Aspirator Controlled by Fiber-Optic Neoplasm Sensor Detecting 5-Aminolevulinic Acid-Derived Porphyrin Fluorescence
Intelligent Ultrasonic Aspirator Controlled by Fiber-Optic Neoplasm Sensor Detecting 5-Aminolevulinic Acid-Derived Porphyrin Fluorescence Open
The development of an intelligent ultrasonic aspirator controlled by a fiber-optic neoplasm sensor that detects 5-aminolevulinic acid-derived porphyrin fluorescence presents a significant advancement in glioma surgery. By leveraging the fl…
View article: Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients
Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients Open
View article: 10112- ET-10 EVALUATING PBC-IP AS A NOVEL BORON CARRIER IN BNCT
10112- ET-10 EVALUATING PBC-IP AS A NOVEL BORON CARRIER IN BNCT Open
This study aims to expand the application scope of boron neutron capture therapy (BNCT) for BPA-insensitive cancers. To apply BNCT in the treatment of brain tumors, convection-enhanced delivery (CED) is used as the drug administration meth…
View article: 10148- ACT-7 BORON NEUTRON CAPTURE THERAPY FROM TWO-DIRECTION FOR HIGH-GRADE MENINGIOMAS ACHIEVED BY PATIENT REPOSITIONING AND CONTINUOUS BPA ADMINISTRATION
10148- ACT-7 BORON NEUTRON CAPTURE THERAPY FROM TWO-DIRECTION FOR HIGH-GRADE MENINGIOMAS ACHIEVED BY PATIENT REPOSITIONING AND CONTINUOUS BPA ADMINISTRATION Open
BACKGROUND High-grade meningiomas are refractory to repeated surgery and radiotherapy. We have performed boron neutron capture therapy (BNCT) for high-grade meningiomas. We report on BNCT for extensive, deep or multiple lesions in recurren…
View article: 10162- TB-6 VALIDATION OF BORON NEUTRON CAPTURE THERAPY WITH EXISTING BORON COMPOUNDS IN A RAT MALIGNANT GLIOMA MODEL
10162- TB-6 VALIDATION OF BORON NEUTRON CAPTURE THERAPY WITH EXISTING BORON COMPOUNDS IN A RAT MALIGNANT GLIOMA MODEL Open
BACKGROUND Boron neutron capture therapy (BNCT) is a biologically targeted particle therapy that utilizes the capture reaction between boron and neutrons. Theoretically, tumor cell-selective boron uptake allows for tumor-selective therapy.…
View article: Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors
Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors Open
Metastatic spinal tumors are increasingly prevalent due to advancements in cancer treatment, leading to prolonged survival rates. This rising prevalence highlights the need for developing more effective therapeutic approaches to address th…
View article: BORON NEUTRON CAPTURE THERAPY USING DIRECT INTRATUMORAL ADMINISTRATION OF A FOLATE RECEPTOR TARGETING NOVEL BORON CARRIER
BORON NEUTRON CAPTURE THERAPY USING DIRECT INTRATUMORAL ADMINISTRATION OF A FOLATE RECEPTOR TARGETING NOVEL BORON CARRIER Open
View article: Termination without global capture: electrocardiographic and anatomical characteristics using 3D-electroanatomical mapping system in reentrant ventricular tachycardia
Termination without global capture: electrocardiographic and anatomical characteristics using 3D-electroanatomical mapping system in reentrant ventricular tachycardia Open
Background Termination without global capture (TWGC) is the phenomenon which a pacing stimulus applied during ventricular tachycardia (VT) terminates the tachycardia without generating a QRS complex, and is considered as an indicator for t…
View article: Postoperative Airway Management after Anterior Cervical Spine Surgery: Retrospective Neurosurgical Multicenter Study
Postoperative Airway Management after Anterior Cervical Spine Surgery: Retrospective Neurosurgical Multicenter Study Open
Airway complications that occur after anterior cervical spine surgery pose a life-threatening risk, which encompasses complications including prolonged intubation, unplanned reintubation, and/or necessity of tracheostomy. The present study…
View article: Evaluation of the Safety of Folate Receptor-Targeted Boron Carrier in Boron Neutron Capture Therapy (BNCT) for Malignant Gliomas Using CED Administration
Evaluation of the Safety of Folate Receptor-Targeted Boron Carrier in Boron Neutron Capture Therapy (BNCT) for Malignant Gliomas Using CED Administration Open
Knowing how to accumulate boron into the tumor cells is a crucial aspect of boron neutron capture therapy (BNCT), which can be targeted at the cellular level, and the development of novel boron agents other than BPA, which is used in clini…
View article: Nonclinical pharmacodynamics of boron neutron capture therapy using direct intratumoral administration of a folate receptor targeting novel boron carrier
Nonclinical pharmacodynamics of boron neutron capture therapy using direct intratumoral administration of a folate receptor targeting novel boron carrier Open
Background Boron neutron capture therapy (BNCT) is a precise particle radiation therapy known for its unique cellular targeting ability. The development of innovative boron carriers is crucial for the advancement of BNCT technologies. Our …
View article: Treatment of High-grade Meningiomas
Treatment of High-grade Meningiomas Open
View article: 10252-COT-27 TWO CASES OF OVARIAN HYPERSTIMULATION SYNDROME IN A YOUNG FEMALE PATIENTS WITH GLIOMA WHO UNDERWENT OOCYTE CRYOPRESERVATION.
10252-COT-27 TWO CASES OF OVARIAN HYPERSTIMULATION SYNDROME IN A YOUNG FEMALE PATIENTS WITH GLIOMA WHO UNDERWENT OOCYTE CRYOPRESERVATION. Open
Young women with malignant gliomas may wish to have their oocytes preserved prior to the start of chemotherapy in order to maintain fertility. In such cases, fertility drugs make it possible to mature and retrieve multiple oocytes in the o…
View article: 10082-RT-1 LONG-TERM RESULTS OF A BNCT PHASE II CLINICAL TRIAL USING AN ACCELERATOR-BASED NEUTRON SOURCE FOR PATIENTS WITH RECURRENT GLIOBLASTOMA
10082-RT-1 LONG-TERM RESULTS OF A BNCT PHASE II CLINICAL TRIAL USING AN ACCELERATOR-BASED NEUTRON SOURCE FOR PATIENTS WITH RECURRENT GLIOBLASTOMA Open
PURPOSE Accelerator-based neutron sources have received regulatory approval and boron neutron capture therapy (BNCT) for head and neck cancer has been introduced into clinical treatment in earnest. BNCT is a radiotherapy with cell-selectiv…
View article: RADT-37. INTERIM RESULTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, RANDOMIZED CONTROLLED TRIAL FOR RECURRENT AND REFRACTORY HIGH-GRADE MENINGIOMAS
RADT-37. INTERIM RESULTS OF ACCELERATOR-BASED BORON NEUTRON CAPTURE THERAPY, RANDOMIZED CONTROLLED TRIAL FOR RECURRENT AND REFRACTORY HIGH-GRADE MENINGIOMAS Open
BACKGROUND High-grade meningiomas (HGMs) recurred after X-ray treatment showed 5.2 months as median progression free survival (mPFS) and only 24.6 months as median overall survival (mOS) from the literatures. Recently, we showed much more …
View article: Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor
Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor Open
Malignant glioma is a highly invasive tumor, and elucidating the glioma invasion mechanism is essential for developing novel therapies. We aimed to highlight actin alpha 2, smooth muscle (ACTA2) as potential biomarkers of brain invasion an…
View article: Increasing C-reactive protein levels in a patient with glioblastoma with lymph node metastasis: a case report
Increasing C-reactive protein levels in a patient with glioblastoma with lymph node metastasis: a case report Open
Background Glioblastoma usually recurs locally and extracranial metastases are rare. Most patients with extracranial metastases experience recurrence of the primary intracranial tumor. Lymph node metastases are often detected based on lymp…
View article: Vertebral artery is an anatomical landmark in the posterior unilateral resection of cervical benign nerve sheath tumors with dumbbell extension of Eden type 2 or 3
Vertebral artery is an anatomical landmark in the posterior unilateral resection of cervical benign nerve sheath tumors with dumbbell extension of Eden type 2 or 3 Open
Background: In the cervical nerve sheath tumor (NST) surgery with dumbbell extension of Eden type 2 or 3, selection of anterior, posterior, or combined approach remains controversial. Objectives: This technical note aimed to propose possib…
View article: Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model
Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model Open
High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron used by t…
View article: Occult neurohypophyseal germinoma discovered during the course of long-term diabetes insipidus: illustrative case
Occult neurohypophyseal germinoma discovered during the course of long-term diabetes insipidus: illustrative case Open
BACKGROUND The authors report a case of occult neurohypophyseal germinoma detected in a patient with long-term diabetes insipidus. Central diabetes insipidus is the initial symptom in 95% of cases of neurohypophyseal germinoma. In occult n…
View article: Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated Closo-Dodecaborate on a Rat Brain Tumor Model
Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated Closo-Dodecaborate on a Rat Brain Tumor Model Open
High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron carrier c…
View article: Is Intraoperative 5-ALA PDD Effective for Brain Tumors Other than Malignant Gliomas!?—5-ALA PDD and Preoperative Image Analysis in Metastatic Brain Tumors—
Is Intraoperative 5-ALA PDD Effective for Brain Tumors Other than Malignant Gliomas!?—5-ALA PDD and Preoperative Image Analysis in Metastatic Brain Tumors— Open
脳腫瘍において，5-アミノレブリン酸（ALA）を用いた光線力学的診断（photodynamic diagnosis: PDD）の有用性はすでに周知されており，2013年には摘出率向上を目的して悪性神経膠腫に対する5-ALA製剤の術前投与が保険承認された．当教室では以前より様々な脳腫瘍に対する5-ALA-PDDを施行しており，蛍光強度の評価は従来行われている術者による主観的評価（肉眼的な3段階評価）に加え，分光スペクトル解析による蛍光強度の定量的評価（蛍光輝度計による測定）を…
View article: 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy
5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy Open
View article: History, Current Status, and Emerging Issue of 5-Aminolevulinic Acid Induced Fluorescence Guided Surgery in Neurological Surgery
History, Current Status, and Emerging Issue of 5-Aminolevulinic Acid Induced Fluorescence Guided Surgery in Neurological Surgery Open
悪性脳腫瘍に対する5-アミノレブリン酸(5-Aminolevulinic Acid: 5-ALA)を用いた蛍光ガイド手術は主に励起光源および観察用フィルターを内蔵した顕微鏡を用いて行われてきた.近年,5-ALAによる蛍光観察可能な内視鏡・サージカルルーペさらには外視鏡が登場し,その有用性が示唆されている.しかし,蛍光評価は長年蓄積された顕微鏡下評価を基盤にしており,新たな観察システムによる蛍光評価はこれらと異なる可能性があり注意が必要である.また,新たな蛍光観察システム導入…
View article: Increasing C-reactive protein levels in a patient with glioblastoma with lymph node metastasis. A case report
Increasing C-reactive protein levels in a patient with glioblastoma with lymph node metastasis. A case report Open
Background: Glioblastoma multiforme is an intractable brain tumor; however, extracranial metastases are rare. The sites of metastasis vary and include the lungs, bone, lymph nodes, and liver, with approximately half of patients with extrac…
View article: Chronic expanding pituitary hematoma with calcification resulting from pituitary adenoma: illustrative case
Chronic expanding pituitary hematoma with calcification resulting from pituitary adenoma: illustrative case Open
BACKGROUND Pituitary apoplexy (PA) is characterized by sudden headache, vomiting, visual dysfunction, anterior lobe dysfunction, and endocrine disorder due to bleeding or infarction from a pituitary adenoma. PA occurs in approximately 0.6–…
View article: Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model
Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model Open
Integrin αvβ3 is more highly expressed in high-grade glioma cells than in normal tissues. In this study, a novel boron-10 carrier containing maleimide-functionalized closo-dodecaborate (MID), serum albumin as a drug delivery system, and cy…
View article: Occult Germinoma of the Intramedullary Spinal Cord: A Case Report
Occult Germinoma of the Intramedullary Spinal Cord: A Case Report Open
Primary germ cell tumors of the central nervous system (CNS) typically occur in the neurohypophysis, hypothalamus, or pineal gland and rarely in the spinal cord. We report a case of a spinal intramedullary tumor, which was first detected o…