Naoto Kawakami
YOU?
Author Swipe
View article: A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model Open
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive understanding of the signaling pathways that regulate this process. Here, we conducted a genome-wide in vivo CRISPR screen …
View article: T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T:B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity Open
Meningeal ectopic lymphoid follicle-like structures (eLFs) have been described in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), but their role in CNS autoimmunity is unclear. To analyze the c…
View article: Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis
Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis Open
SUMMARY Multiple sclerosis (MS) is a neuroinflammatory disease initiated by the infiltration of autoreactive T cells into the central nervous system (CNS). Several molecules that modulate T cell CNS infiltration in MS have been identified,…
View article: Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity Open
View article: Correction to: Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis
Correction to: Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis Open
View article: 1er Taller Internacional "Enfermedades autoinmunes y el cerebro: Patogénesis y desarrollo de fármacos"
1er Taller Internacional "Enfermedades autoinmunes y el cerebro: Patogénesis y desarrollo de fármacos" Open
Resúmenes de los 12 trabajos presentados en el Taller.
View article: Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses Open
Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to be a continuous process. Here, we show that lymphocyte migration through lymph nodes and lymph occurred in a non-continuous, circadian manner. Lymp…
View article: Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease
Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease Open
These data link CXCL12 expression in the DG and CC of EAE-recovering mice to the promotion of neuro/oligodendrogenesis generating CXCR4(+) CXCL12(+) neuronal and oligodendrocyte progenitor cells endowed with intrinsic neuro/oligondendrogli…