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View article: The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high <i>MYC</i> malignancies
The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high <i>MYC</i> malignancies Open
Ribosome biogenesis (RiBi) is a key determinant of cell growth and proliferation and is highly elevated in cancer due to the activation by oncogenes such as MYC . First-generation RiBi inhibitor CX-5461, while demonstrating clinical potent…
View article: Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome
Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome Open
The innate immune response contributes to the development or attenuation of acute and chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged host cells can activate different host responses that shape disease o…
View article: The role of exercise in limiting progression from liver inflammation and fibrosis to cirrhosis and carcinoma: a systematic review with meta-analysis of human and animal studies
The role of exercise in limiting progression from liver inflammation and fibrosis to cirrhosis and carcinoma: a systematic review with meta-analysis of human and animal studies Open
Background Exercise may prevent the progression of liver disease and protect against liver cancer. This review with meta-analysis synthesised the evidence from both human and animal studies to better understand whether exercise has the cap…
View article: Vale Professor William Doe (6 May 1941–23 August 2022)
Vale Professor William Doe (6 May 1941–23 August 2022) Open
Professor William (Bill) Doe was one of the most outstanding academic gastroenterologists produced by Australia and a major leader in the development of regional cooperation in Asia-Pacific Gastroenterology. He was a very highly regarded c…
View article: Statins as early therapy to mitigate COVID-19 (SARS-CoV-2)-associated ARDS and cytokine storm syndrome – time is of the essence
Statins as early therapy to mitigate COVID-19 (SARS-CoV-2)-associated ARDS and cytokine storm syndrome – time is of the essence Open
While most coronavirus disease 2019 (COVID-19) infections run a benign course with recovery, the inexorable rise in case fatalities in several countries is grim testimony to the lack of effective therapies to arrest the course of severe in…
View article: Recent advances in the management of hepatocellular carcinoma: First, cut … is the deepest or is it “no‐touch” and exercise?
Recent advances in the management of hepatocellular carcinoma: First, cut … is the deepest or is it “no‐touch” and exercise? Open
Remarkable advances have been made in the curative management of hepatocellular carcinoma (HCC) in the past decade, particularly by surgical means, with the continuing refinement of intraoperative instruments and technique, perioperative c…
View article: The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion
The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion Open
View article: Mouse Models of Nonalcoholic Steatohepatitis
Mouse Models of Nonalcoholic Steatohepatitis Open
Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental factors and genetic determinants that cannot be completely replicated in animals. Notwithstanding, preclinical models are needed to understand NASH …
View article: Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis
Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis Open
Recently, FXR agonists have been shown to promote regeneration via the gut-liver axis. This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx. In light of these developments, th…
View article: NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice Open
View article: Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-kB or Akt/mTORC1
Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-kB or Akt/mTORC1 Open
BACKGROUND: There are strong links between obesity, diabetes and hepatocellular carcinoma (HCC), but molecular mechanisms remain unclear. AIM: We tested the proposed involvement of NF-κB, IL-6/STAT3 and Akt/mTORC1 before onset (at 3 months…
View article: Parallel 7: Liver Transplant Diseases and Perioperative Management
Parallel 7: Liver Transplant Diseases and Perioperative Management Open
black tea.The mean ALT noted in 657 individuals within 3 months of TE was 60.6 U/L.The average BMI was 25.7 kg/m 2 and weight was 71.7 kg.Average daily alcohol consumption was 5 g/day.The average liver stiffness for the 1155 individuals wa…
View article: Parallel 8: Novel Molecular Targets in NASH
Parallel 8: Novel Molecular Targets in NASH Open
may help refine post-LT HCC surveillance strategies and identify patients who would derive the most benefits from future post-LT adjuvant therapies.
View article: Parallel 34: Experimental Hepatocarcinogenesis
Parallel 34: Experimental Hepatocarcinogenesis Open
327Ashowed enhanced mitochondrial translocation of JNK accompanied by an increase in the release of mitochondrial enzymes, such as apoptosis-inducing factor and endonuclease G, into the cytosol, which is indicative of increased mitochondri…
View article: Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice
Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice Open
Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose function and inflammation are less clear. Accordingly, it was hypothesized that exe…
View article: Acute atorvastatin is hepatoprotective against ischaemia‐reperfusion injury in mice by modulating <scp>eNOS</scp> and microparticle formation
Acute atorvastatin is hepatoprotective against ischaemia‐reperfusion injury in mice by modulating <span>eNOS</span> and microparticle formation Open
Background & Aims Steatosis accentuates the severity of hepatic ischaemia‐reperfusion injury ( IRI ); ‘statins’ ( HMG ‐CoA reductase inhibitors) protect the heart and brain against post‐ischaemic injury. We tested whether short‐term admini…