Explanipedia

Neonatal Morbidities and Hospitalization in the First 2 Years of Life Among Infants Born Very Preterm Open

Tim J van Hasselt, Rebecca A. Dorner, Anup Katheria, Cheryl Battersby, Christopher Gale , et al. · 2025

Importance Children born very preterm have increased health care use. However, there is a lack of research using contemporary national data quantifying hospitalizations after neonatal discharge to inform counseling of families and health c…

Meeting the needs of women in the perinatal period, who use or are in treatment for using drugs: A mixed-methods systematic review Open

Emma Smith, Shirley Lewis, Lynne Gilmour, Louise Honeybul, Helen Cheyne , et al. · 2025

Background Women who use and/or are in treatment for using drugs during the perinatal period have complex health and social care needs. Substance use in the perinatal period is multifaceted, with many confounding factors that may impact th…

Navigating surveillance: The experience of prenatal women who use or who are in treatment for using drugs Open

Polly Radcliffe, Emma Smith, Shirley Lewis, Louise Honeybul, Lynne Gilmour , et al. · 2025

There is little knowledge of how women who use and are in treatment for using drugs in the perinatal period experience multidisciplinary services prenatally. This study used qualitative longitudinal methods to explore women’s experiences o…

The effect of haemoglobin and blood transfusion on preterm infant gut perfusion and injury Open

Claire Howarth, Christian Mifsud, Jayanta Banerjee, Simon Eaton, Terence S. Leung , et al. · 2024

Introduction There is significant uncertainty regarding the role that anaemia or red blood cell transfusion (RBCT) plays in the development of gut injury in preterm infants. This study evaluated Near Infrared Spectroscopy (NIRS) together w…

Hearing loss in newborn infants with hypoxic ischaemic encephalopathy: protocol for a case–control study Open

Sujith S. Pereira, Mario D’Costa, Narendra Aladangady · 2024

Introduction Hypoxic ischaemic encephalopathy (HIE), a condition where the brain does not receive enough oxygen and/or blood flow around the time of birth, is associated with significant morbidity and mortality. Systemic circulation may be…

Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy Open

Paolo Montaldo, Mario Cirillo, Constance Burgod, Elisabetta Caredda, Serena Ascione , et al. · 2024

Importance Although whole-body hypothermia is widely used after mild neonatal hypoxic-ischemic encephalopathy (HIE), safety and efficacy have not been evaluated in randomized clinical trials (RCTs), to our knowledge. Objective To examine t…

Correction: Investigating Father or Partner Involvement in Family Integrated Care in Neonatal Units: Protocol for a Prospective, Multicenter, Multiphase Study Open

Rupa Rubinstein, Katie Gallagher, John Ho, Julian Bose, Minesh Khashu , et al. · 2024

[This corrects the article DOI: 10.2196/53160.].

Achieving optimal cord management: a multidisciplinary quality improvement initiative Open

Jessica Burgess-Shannon, Rebecca Clarke, Victoria Rowell, Narendra Aladangady · 2024

Optimal cord management (OCM), defined as waiting at least 60 seconds (s) before clamping the umbilical cord after birth, is an evidence-based intervention that improves outcomes for both term and preterm babies. All major resuscitation co…

Examining the impact and response to an outbreak of carbapenemase-producing <i>Enterobacterales</i> in a neonatal unit in the United Kingdom: An outbreak report Open

Megha Anil, Jacki Dopran, Alleyna Claxton, Paul Fleming, Narendra Aladangady · 2024

Background Carbapenemase-producing Enterobacterales (CPE) are a group of Gram-negative bacteria causing global concern due to their resistance to carbapenems. In this report, we detail the learning points from a CPE outbreak in a tertiary …

The Effect of Haemoglobin and Blood Transfusion on Preterm Infant Gut Perfusion and Injury Open

Claire Howarth, Christian Mifsud, Jayanta Banerjee, Simon Eaton, Terence S. Leung , et al. · 2024

There is significant uncertainty regarding the role of anaemia or blood transfusion in the development of necrotising enterocolitis in preterm infants. We conducted a prospective observational study of 48 preterm infants born at <30 weeks …

Scoping review: mapping clinical guidelines and policy documents that address the needs of women who are dependent on drugs during the perinatal period Open

Lynne Gilmour, Louise Honeybul, Shirley Lewis, Emma Smith, Helen Cheyne , et al. · 2024

Investigating Father or Partner Involvement in Family Integrated Care in Neonatal Units: Protocol for a Prospective, Multicenter, Multiphase Study Open

Rupa Rubinstein, Katie Gallagher, John Ho, Julian Bose, Minesh Khashu , et al. · 2024

Background Neonatal unit (NU) admissions for premature babies can last for months, which can significantly impact parental mental health (MH) with symptoms of depression, stress, and anxiety. Literature suggests fathers experience comparab…

A Systematic Review of the Experiences of Family Integrated Care (FICare) for Fathers of Preterm Babies in the Neonatal Unit Setting Open

Rupa Rubinstein, Valentina Pompa, Kaye Bagshaw, John Ho, Minesh Khashu , et al. · 2024

Investigating Father or Partner Involvement in Family Integrated Care in Neonatal Units With TARGET (Fathers and Partners in Family Integrated Care): Protocol for a Prospective, Multicenter, Multiphase Study (Preprint) Open

Rupa Rubinstein, Katie Gallagher, John Ho, Julian Bose, Minesh Khashu , et al. · 2023

BACKGROUND Neonatal unit (NU) admissions for premature babies can last for months, which can significantly impact parental mental health (MH) with symptoms of depression, stress, and anxiety. Literature suggests fathers experience compara…

Measuring gut perfusion and blood flow in neonates using ultrasound Doppler of the superior mesenteric artery: a narrative review Open

Catherine Murphy, S. Baskind, Narendra Aladangady, Jayanta Banerjee · 2023

The gut is a relatively silent organ in utero but takes on a major role after birth for the absorption and digestion of feed for adequate nutrition and growth. The neonatal circulation undergoes a transition period after birth, and gut per…

Editorial: Biomarkers of gut blood flow, oxygenation, inflammation and NEC in neonates Open

Narendra Aladangady, Ian R. Sanderson · 2023

EDITORIAL article Front. Pediatr., 05 July 2023Sec. Neonatology Volume 11 - 2023 | https://doi.org/10.3389/fped.2023.1234832

Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants Open

Narendra Aladangady, Ajay Sinha, Jayanta Banerjee, Felix Asamoah, Asha Mathew , et al. · 2023

Background: There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely preterm infants mana…

Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants Open

Narendra Aladangady, Ajay Sinha, Jayanta Banerjee, Felix Asamoah, Asha Mathew , et al. · 2023

Background There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely preterm infants manag…

Abdominal Near Infrared Spectroscopy can be reliably used to measure splanchnic oxygenation changes in preterm infants Open

R. A. Thomas, M-R Ballard, Narendra Aladangady, Jayanta Banerjee · 2022

Biomarkers of gut injury in neonates – where are we in predicting necrotising enterocolitis? Open

Claire Howarth, Jayanta Banerjee, Simon Eaton, Narendra Aladangady · 2022

Despite advances in neonatal care Necrotising Enterocolitis (NEC) continues to have a significant mortality and morbidity rate, and with increasing survival of those more immature infants the population at risk of NEC is increasing. Ischae…

Attitudes About Extremely Preterm Birth Among Obstetric and Neonatal Health Care Professionals in England Open

Katie Gallagher, Chloë Shaw, Maryam Parisaei, Neil Marlow, Narendra Aladangady · 2022

Importance Variation in attitudes between health care professionals involved in the counseling of parents facing extremely preterm birth (<24 wk gestational age) may lead to parental confusion and professional misalignment. Objectiv…

Could Near Infrared Spectroscopy (NIRS) be the new weapon in our fight against Necrotising Enterocolitis? Open

Claire Howarth, Jayanta Banerjee, Terence S. Leung, Narendra Aladangady · 2022

There is no ideal single gut tissue or inflammatory biomarker available to help to try and identify Necrotising Enterocolitis (NEC) before its clinical onset. Neonatologists are all too familiar with the devastating consequences of NEC, an…

Methaemoglobinaemia associated with use of glyceryl trinitrate patches in an extremely preterm infant Open

Sujith S. Pereira, Beena Yeldo, Narendra Aladangady · 2022

Methaemoglobin represents an altered haemoglobin where the iron of heme is oxidised from its normal ferrous (Fe2+) form to the abnormal ferric (Fe3+) form. Methaemoglobin is unable to bind to oxygen and therefore associated with hypoxia an…

End-of-Life Decision Making Between Doctors and Parents in NICU: The Development and Assessment of a Conversation Analysis Coding Framework Open

Chloë Shaw, Kathrina Connabeer, Paul Drew, Katie Gallagher, Narendra Aladangady , et al. · 2022

We report the development and assessment of a novel coding framework in the context of research into neonatal end-of-life decision making conversations. Data comprised 27 formal conversations between doctors and parents of critically ill b…

Possible In Utero Transmission of SARS-CoV-2 and Severe Respiratory Disease in a Preterm Infant Open

Paul Fleming, Sujith S. Pereira, Olga Kapellou, Alleyna Claxton, Alasdair Bamford , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 infections are uncommon in newborn infants. This report describes possible in utero transmission of the B.1.1.7 (alpha) variant in a preterm infant born at 31 weeks’ gestational age who prese…

Demand for regional level III neonatal services is not reduced during national COVID lockdowns Open

Isobel Kenney, Natalie Maalouf, G. Adams, K. Grayson, Nasser Brown , et al. · 2021

Systematic review of medical literature for medicolegal claims and complaints involving neonates Open

Apoorva Aiyengar, Tom Morris, Kaye Bagshaw, Narendra Aladangady · 2021

Importance Complaints and malpractice claims by families on the care of their babies are pertinent issue. Beyond just the financial implications, it involves harm to babies and distress to parents. Objective The aim was to review published…

Increase in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study Open

Jonathan Cusack, Matthew Babirecki, Liza Harry, Tim Wickham, L M Wong , et al. · 2021

Objective To describe temporal changes in inhaled nitric oxide (iNO) use in English neonatal units between 2010 and 2015. Design Retrospective analysis using data extracted from the National Neonatal Research Database. Setting All National…

Neonatal and perinatal palliative care pathway: a tertiary neonatal unit approach Open

Abena Akyempon, Narendra Aladangady · 2021

A lack of well-structured guideline or care pathway results in inadequate, inconsistent and fragmented palliative care (PC) for babies and their families. The impact on the families could be emotionally and psychologically distressing. Not…

Regional Cerebral and Splanchnic Tissue Oxygen Saturation in Preterm Infants – Longitudinal Normative Measurements Open

Claire Howarth, Terence Leung Leung, Jayanta Banerjee, Simon Eaton, Joan K. Morris , et al. · 2021

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