Naresh Kumar Katari
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View article: Green metrics and quality by design tool evaluated UPLC content determination method for Sparsentan in formulation sample
Green metrics and quality by design tool evaluated UPLC content determination method for Sparsentan in formulation sample Open
View article: New molecular hybrids of spirochromanone and carbamide: Design, synthesis, docking and in vitro anticancer studies
New molecular hybrids of spirochromanone and carbamide: Design, synthesis, docking and in vitro anticancer studies Open
View article: Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities
Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities Open
This study investigates the antibacterial and anti‐diabetic properties of synthesized thioxolone derivatives. Compounds T‐11 , T‐12 , and T‐13 exhibited significant inhibitory effects at all tested concentrations, demonstrating antibacteri…
View article: Quality-by-Design-Driven RP-HPLC Method Development and Validation for Impurity Analysis of Elexacaftor, a Cystic Fibrosis Drug, with LC-MS/MS-Based Degradant Identification
Quality-by-Design-Driven RP-HPLC Method Development and Validation for Impurity Analysis of Elexacaftor, a Cystic Fibrosis Drug, with LC-MS/MS-Based Degradant Identification Open
The development and validation of an analytical technique based on RP-HPLC for the determination of impurities in Elexacaftor (ELX). Using a straightforward and stability-indicating HPLC technique, six known contaminants were precisely ass…
View article: A comprehensive approach to green and robust UPLC method for combined antihypertensive drugs
A comprehensive approach to green and robust UPLC method for combined antihypertensive drugs Open
View article: Novel 2,4-thiazolidinedione-quinoline hybrid molecules as REV-ERBα modulators for the treatment of diabetes mellitus
Novel 2,4-thiazolidinedione-quinoline hybrid molecules as REV-ERBα modulators for the treatment of diabetes mellitus Open
View article: Liquid chromatography method for quantification of five impurities in Bilastine tablet formulation; robustness study by design expert
Liquid chromatography method for quantification of five impurities in Bilastine tablet formulation; robustness study by design expert Open
The current work proposes a particular, accurate, simple, and speedy HPLC approach for detecting impurities in Bilastine (BLS) tablet formulations. A gradient mode elution buffer solution (10 mm Potassium dihydrogen phosphate and 10 mm Di-…
View article: Development and Validation of an RP‐HPLC Method for Organic Impurity Profiling in Baclofen Utilizing Robustness Through a Quality‐by‐Design (QbD) Approach: A Comprehensive Forced Degradation Assessment
Development and Validation of an RP‐HPLC Method for Organic Impurity Profiling in Baclofen Utilizing Robustness Through a Quality‐by‐Design (QbD) Approach: A Comprehensive Forced Degradation Assessment Open
Strong understandings of science and risk evaluation methodologies are needed to design an analytical method for pharmaceutical quality assessment. This article provides an HPLC method for separating and quantifying baclofen and related im…
View article: Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new α-glucosidase inhibitors
Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new α-glucosidase inhibitors Open
A new series of benzisoxazole derivatives (9a-o) were designed by using molecular hybridization approach and synthesized via click-chemistry. All the synthesized compounds were evaluated for their α-glucosidase enzyme inhibit…
View article: Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors
Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors Open
This study assesses newly synthesized chromones with a 3,4‐dihydropyrimidin‐2(1H)‐one core at C‐3, combined with triazole derivatives for their antidiabetic potential. Compounds 5a and 5b showed strong inhibition of α‐glucosidase, with IC …
View article: Heptad green metrics and quality by design tool evaluated chromatography method for content determination of Bexagliflozin in formulation product
Heptad green metrics and quality by design tool evaluated chromatography method for content determination of Bexagliflozin in formulation product Open
View article: Utilizing quality by design methodology for liquid chromatography method development and validation in quantifying impurities in Pitolisant, a Histamine-3 (H3) receptor antagonist/inverse agonist
Utilizing quality by design methodology for liquid chromatography method development and validation in quantifying impurities in Pitolisant, a Histamine-3 (H3) receptor antagonist/inverse agonist Open
View article: Ultra sensitive ammonia sensing using TDA Schiff base MOFs: complementary strategy for gas detection at room temperature
Ultra sensitive ammonia sensing using TDA Schiff base MOFs: complementary strategy for gas detection at room temperature Open
View article: Quality by Design Based Chromatography Technique Development and Validation for the Medicine Venetoclax (for Chronic Leukemia), in the Context of Impurities Including Degradation Products
Quality by Design Based Chromatography Technique Development and Validation for the Medicine Venetoclax (for Chronic Leukemia), in the Context of Impurities Including Degradation Products Open
The present research study describes the Venetoclax (VEN)‐related substances test method using RP‐HPLC/DAD techniques. It was developed and validated according to ICH Q14 and Q2(R2) guidelines. The substances were separated using an X‐Brid…
View article: Pyrimidine fused heterocyclic derivatives: Design, in silico, in vitro, anti-microbial, antidiabetic and anti-biofilm studies
Pyrimidine fused heterocyclic derivatives: Design, in silico, in vitro, anti-microbial, antidiabetic and anti-biofilm studies Open
Pyrimidine-fused derivatives that are an inextricable part of DNA and RNA play a key role in the normal life cycle of cells. Here, we synthesized new pyrimidine-tetrazolo/pyrimidocarboxylic acids (5a-f and 8a-f) with high yields using new …
View article: Combination of Ethylene glycol and TBAB-mediated pyrimidine fused heterocyclic derivatives: Synthesis, in silico, and in vitro anti-diabetic and anti-microbial studies
Combination of Ethylene glycol and TBAB-mediated pyrimidine fused heterocyclic derivatives: Synthesis, in silico, and in vitro anti-diabetic and anti-microbial studies Open
Pyrimidine-fused heterocyclic compounds exhibit pharmacological activity, including anti-diabetic and antibacterial, antifungal properties. This study involves the design and synthesis of pyrimidine-fused heterocyclic compounds in conjunct…
View article: Unique Research for Developing a Full Factorial Design Evaluated Liquid Chromatography Technique for Estimating Budesonide and Formoterol Fumarate Dihydrate in the Presence of Specified and Degradation Impurities in Dry Powder Inhalation
Unique Research for Developing a Full Factorial Design Evaluated Liquid Chromatography Technique for Estimating Budesonide and Formoterol Fumarate Dihydrate in the Presence of Specified and Degradation Impurities in Dry Powder Inhalation Open
A simple LC method has been developed and validated for estimating budesonide (epimer B + A) and formoterol fumarate dihydrate in dry powder inhalation. The development results of this study make it very significant. The degradation and pr…
View article: Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl
Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl Open
A new selective and sensitive high‐performance liquid chromatography (HPLC) method was developed for the quantification of potential impurities in fluoxetine hydrochloride. Chromatographic separation was achieved on an end‐capped octadecyl…
View article: A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method
A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method Open
The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of NDSRI impurities in mefenamic acid (MFA) tablet and pediatric suspension dosage forms.
View article: Zinc-encapsulating covalent organic frameworks for enhanced chemiresistive NH<sub>3</sub> sensing at room temperature
Zinc-encapsulating covalent organic frameworks for enhanced chemiresistive NH<sub>3</sub> sensing at room temperature Open
A Zn-encapsulating COF sensor (Zn@COF-3) fabricated via a drop-casting method demonstrates a selective and rapid chemiresistive response to NH 3 gas at room temperature, making it suitable for real-time gas sensor applications.
View article: Zinc-doped covalent organic frameworks as high-efficiency chemiresistors for acetylene gas detection
Zinc-doped covalent organic frameworks as high-efficiency chemiresistors for acetylene gas detection Open
This paper investigates the synthesis and characterization of DADE-Tp COF and zinc-doped DADE-Tp COF, demonstrating their capabilities for acetylene gas detection.
View article: Synthesis, characterization, and <i>in vitro</i> and <i>in silico</i> α-glucosidase inhibitory evolution of novel <i>N</i>′-(2-cyclopentyl-2-phenylacetyl)cinnamohydrazide derivatives
Synthesis, characterization, and <i>in vitro</i> and <i>in silico</i> α-glucosidase inhibitory evolution of novel <i>N</i>′-(2-cyclopentyl-2-phenylacetyl)cinnamohydrazide derivatives Open
To discover potential α-glucosidase inhibitory agents, a new series of N ′-(2-cyclopentyl-2-phenylacetyl)cinnamohydrazide derivatives were designed and synthesized as α-glucosidase inhibitors.
View article: Design, synthesis, and biological evaluation of novel 3-oxo-2,3-dihydropyridazine derivatives as interleukin-2-inducible T-cell kinase (ITK) inhibitors
Design, synthesis, and biological evaluation of novel 3-oxo-2,3-dihydropyridazine derivatives as interleukin-2-inducible T-cell kinase (ITK) inhibitors Open
This study reports the design, synthesis, and biological evaluation of a novel series of 3-oxo-2,3-dihydropyridazine derivatives for selective inhibition of ITK, with potential application in T-cell leukemia treatment.
View article: Titanium Dioxide/Graphene‐Based Nanocomposites as Photocatalyst for Environmental Applications: A Review
Titanium Dioxide/Graphene‐Based Nanocomposites as Photocatalyst for Environmental Applications: A Review Open
Nanostructured‐based photocatalysts have always exhibited the potential to solve various environmental issues resulting from global urbanization and industrialization. The creation of nanostructured materials has given humans access to var…
View article: Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and <i>in Vitro</i> Anticancer Studies
Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and <i>in Vitro</i> Anticancer Studies Open
Molecular hybrids of diversely functionalized quinoline and sulfonamide have been designed. Multistep synthetic strategies have been used for the synthesis. The anti‐cancer properties have been evaluated against various cancer cell lines i…
View article: Acid Degradation Study of Dapagliflozin: Structural Characterization of Dapagliflozin and its Degradation Products Using Advanced Analytical Techniques and In Silico Toxicity Prediction
Acid Degradation Study of Dapagliflozin: Structural Characterization of Dapagliflozin and its Degradation Products Using Advanced Analytical Techniques and In Silico Toxicity Prediction Open
The research investigates the stress degradation behavior of Dapagliflozin (DAP), a type‐2 diabetic treatment, following International Council for Harmonization Guidelines. It found that DAP is stable in thermal, photolytic, neutral, and a…
View article: Stability indicating RP‐HPLC method development and validation for quantification of impurities in gonadotropin‐releasing hormone (Elagolix): Robustness study by quality by design
Stability indicating RP‐HPLC method development and validation for quantification of impurities in gonadotropin‐releasing hormone (Elagolix): Robustness study by quality by design Open
The purpose of this research was to establish and validate a reverse phase HPLC method for the determination of Elagolix impurities in pharmaceutical dosage form. Mobile phase A, consisting of 10 mM sodium dihydrogen phosphate (pH 6.0) and…
View article: Greenness assessment for the control of trace-level genotoxic process impurities in Vildagliptin by liquid chromatography with mass spectrometry
Greenness assessment for the control of trace-level genotoxic process impurities in Vildagliptin by liquid chromatography with mass spectrometry Open
View article: Design, Synthesis, and Biological Evaluation of Novel Heterocyclic Derivatives of 2,4‐Thiazolidine Dione as Anti‐Cancer Agents
Design, Synthesis, and Biological Evaluation of Novel Heterocyclic Derivatives of 2,4‐Thiazolidine Dione as Anti‐Cancer Agents Open
This study explores the development of novel 2,4‐thiazolidinedione derivatives as potential anticancer agents. We report the synthesis of 15 novel analogs utilizing a strategic approach focused on intermediate diversification. Key intermed…
View article: Convenient Synthesis, Characterizations and Biological Evolution of Novel 1‐Phenyl‐N’‐(3‐phenylacryloyl)cyclopropane carbohydrazide Derivatives
Convenient Synthesis, Characterizations and Biological Evolution of Novel 1‐Phenyl‐N’‐(3‐phenylacryloyl)cyclopropane carbohydrazide Derivatives Open
Cancer is a longstanding worldwide issue, current chemotherapeutic treatments have limited effectiveness and high toxicity. An extensive investigation has revealed a significant potential link between ITK and the development of cancer. Hen…