Ram Naresh Pandey
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View article: Table S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Table S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Patient tumor information
View article: Supplementary Data File S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Supplementary Data File S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Western blots and quantifications
View article: Figure S5 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S5 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Immunofluorescence images of CCH2 and NCH6 cells stained with antibodies towards IGF1R (red) and PCNA (green).
View article: Figure S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
A. Bright field images of CCH1 and CCH2 cells B. CCH1 and CCH2 cells cells stained with antibody towards CD99 (green) and DAPI (blue) C. Western blots on CCH1 and CCH2 cell lysates probed with the indicated antibodies, confirming differenc…
View article: Figure S3 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S3 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
A. Representative images for DNA fiber experiments conducted on CCH1 and CCH2 cells. In each image asterisk (*) indicates a normal fork (red-green), “N” indicates a new fork (red only), and “S” indicates a stalled fork (green only).B. Brig…
View article: Figure S2 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S2 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Cell cycle analyses A. Dansylcadaverine-mediated nIGF1R depletion arrested CCH1 cells at the G1-phase and reduced the percentage of cells in the S-phase. B. Western blots show that Cyclin A2 and Cyclin D1 levels were high in CCH5 cells wit…
View article: Data from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Data from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
EWSR1/FLI1, the most common fusion gene in Ewing sarcoma, upregulates expression of the Eyes Absent 3 (EYA3) transactivator–phosphatase protein. The purpose of this study was to investigate molecular and cellular mechanisms through …
View article: Figure S2 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S2 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Loss of EYA3 in LLC cells leads to reduced tumor growth.
View article: Figure S1 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S1 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S1 shows EYA3 expression levels in Ewing sarcoma cells, the effect of loss of Eya3 on cell migration and proliferation, and the effect of BZ on a tumor xenograft generated with A673 cells lacking EYA3.
View article: Figure S3 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S3 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
BZ cytotoxicity assay
View article: Data from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Data from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
EWSR1/FLI1, the most common fusion gene in Ewing sarcoma, upregulates expression of the Eyes Absent 3 (EYA3) transactivator–phosphatase protein. The purpose of this study was to investigate molecular and cellular mechanisms through …
View article: Figure S1 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S1 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Tamoxifen-induced loss of EYA3 protein in the tumor vasculature of Eya3VEC-KO mice.
View article: Figure S2 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S2 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Loss of EYA3 in LLC cells leads to reduced tumor growth.
View article: Figure S1 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S1 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S1 shows EYA3 expression levels in Ewing sarcoma cells, the effect of loss of Eya3 on cell migration and proliferation, and the effect of BZ on a tumor xenograft generated with A673 cells lacking EYA3.
View article: Figure S4 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S4 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Representative hematoxylin and eosin staining of vehicle and BZ treated LLC tumors.
View article: Figure S4 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S4 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Representative hematoxylin and eosin staining of vehicle and BZ treated LLC tumors.
View article: Figure S1 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S1 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
Tamoxifen-induced loss of EYA3 protein in the tumor vasculature of Eya3VEC-KO mice.
View article: Figure S3 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S3 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S3 documents how loss of Eya3 or BZ treatment affects multicellular tumor spheroids generated with A673 and RD-ES cells.
View article: Figure S3 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Figure S3 from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
BZ cytotoxicity assay
View article: Figure S4 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S4 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S4 documents the effect of Eya3 loss and BZ treatment on DNA damage and repair in tumor cells and how tumor cell conditional medium affects endothelial cell proliferation and migration.
View article: Figure S2 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S2 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S2 documents the effects of loss of Eya3 in additional Ewing sarcoma cell lines and with additional clones.
View article: Figure S4 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S4 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S4 documents the effect of Eya3 loss and BZ treatment on DNA damage and repair in tumor cells and how tumor cell conditional medium affects endothelial cell proliferation and migration.
View article: Figure S3 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S3 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S3 documents how loss of Eya3 or BZ treatment affects multicellular tumor spheroids generated with A673 and RD-ES cells.
View article: Data from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Data from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
DNA damage repair capacity is required for cells to survive catastrophic DNA damage and proliferate under conditions of intratumoral stress. The ability of the minor histone protein H2AX to serve as a hub for the assembly of a productive D…
View article: Figure S2 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
Figure S2 from Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis Open
Figure S2 documents the effects of loss of Eya3 in additional Ewing sarcoma cell lines and with additional clones.
View article: Data from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth
Data from The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth Open
DNA damage repair capacity is required for cells to survive catastrophic DNA damage and proliferate under conditions of intratumoral stress. The ability of the minor histone protein H2AX to serve as a hub for the assembly of a productive D…
View article: Figure S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S1 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
A. Bright field images of CCH1 and CCH2 cells B. CCH1 and CCH2 cells cells stained with antibody towards CD99 (green) and DAPI (blue) C. Western blots on CCH1 and CCH2 cell lysates probed with the indicated antibodies, confirming differenc…
View article: Figure S3 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S3 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
A. Representative images for DNA fiber experiments conducted on CCH1 and CCH2 cells. In each image asterisk (*) indicates a normal fork (red-green), “N” indicates a new fork (red only), and “S” indicates a stalled fork (green only).B. Brig…
View article: Table S2 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Table S2 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Reagents, instruments, tumor cell culture details
View article: Figure S4 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Figure S4 from Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition Open
Characterization of Ewing sarcoma cell lines A673, RD-ES and SK-ESA.Western blot analysis of the IGF1R signaling pathway B. Western blot analysis of markers associated with the Replication Stress Response C. Western blot analysis of RPA ph…