Narinder Paul
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View article: New Insights into the Pathophysiology of Type 2 Diabetes: A Review Article
New Insights into the Pathophysiology of Type 2 Diabetes: A Review Article Open
A BSTRACT Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia resulting from insulin resistance, impaired insulin secretion, and dysregulated glucose homeostasis. Despite advances in under…
View article: Airway mucus and <sup>129</sup>Xe MRI ventilation after single inhaler triple therapy in asthma
Airway mucus and <sup>129</sup>Xe MRI ventilation after single inhaler triple therapy in asthma Open
Background In asthma, fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) was previously demonstrated to improve forced expiratory volume in 1 s (FEV 1 ) and asthma control, but the mechanism by which this occurs, especially at the le…
View article: <u>Assessment of Glucosuria and Ketonuria in Diabetic Patients Attending Gitwe District Hospital</u>
Assessment of Glucosuria and Ketonuria in Diabetic Patients Attending Gitwe District Hospital Open
Background: Glucosuria and ketonuria are serious condition which mostly occur and affect in diabetes mellitus. Glycosuria is a rare condition in which kidney excrete glucose into the urine, nearly always caused by elevated blood glucose le…
View article: Evaluation of Proteinuria in Diabetic Patients Attending Gitwe District Hospital
Evaluation of Proteinuria in Diabetic Patients Attending Gitwe District Hospital Open
Background: Proteinuria is a serious condition in which body proteins leak into urine due to kidney dysfunction nearly always caused by elevated serum glucose due to prolonged diabetes. Proteinuria occurs and affects individuals with diabe…
View article: Incidence and Maternal Outcome of All Caesarean Hysterectomy in Tertiary Level Hospitals
Incidence and Maternal Outcome of All Caesarean Hysterectomy in Tertiary Level Hospitals Open
Background: Cesarean hysterectomy is a significant obstetric intervention, often performed in life-threatening circumstances. Understanding its incidence, demographic patterns, and associated complications is essential for improving matern…
View article: Diagnostic Accuracy in Detecting Fungal Infection with Ultra-Low-Dose Computed Tomography (ULD-CT) Using Filtered Back Projection (FBP) Technique in Immunocompromised Patients
Diagnostic Accuracy in Detecting Fungal Infection with Ultra-Low-Dose Computed Tomography (ULD-CT) Using Filtered Back Projection (FBP) Technique in Immunocompromised Patients Open
Purpose: To compare the accuracy of ultra-low-dose (uLDCT) to standard-of-care low-dose chest CT (LDCT) in the detection of fungal infection in immunocompromised (IC) patients. Method and Materials: One hundred IC patients had paired chest…
View article: Resection of a Large Hemorrhagic Mediastinal Lymphangioma in an Adult Patient: A Radiologic-Pathologic Correlation
Resection of a Large Hemorrhagic Mediastinal Lymphangioma in an Adult Patient: A Radiologic-Pathologic Correlation Open
Lymphangiomas are rare benign lesions resulting from abnormal proliferation and sequestration of lymphatic tissues that are disconnected from the rest of the lymphatic system. This is a case of a 50-year-old woman with an unusually large m…
View article: <b>P</b>rospective Clinical Trial Comparing IV Esmolol to IV Metoprolol in CT Coronary Angiography: Effect on Hemodynamic, Technical Parameters and Cost
<b>P</b>rospective Clinical Trial Comparing IV Esmolol to IV Metoprolol in CT Coronary Angiography: Effect on Hemodynamic, Technical Parameters and Cost Open
Background: Intravenous [IV] esmolol, an alternative to IV metoprolol for coronary computed tomography angiography [CCTA], has shorter half-life that decreases the risk of prolonged hypotension. The primary aim was to prospectively compare…
View article: Low dose computed tomography of the lung for detection and grading of interstitial lung disease: A systematic simulation study
Low dose computed tomography of the lung for detection and grading of interstitial lung disease: A systematic simulation study Open
Assessment of ILD specific CT features down to 20 mA and a slice thickness of 3 or 5 mm is feasible.
View article: Restricting motion effects in CT coronary angiography
Restricting motion effects in CT coronary angiography Open
Objective: Evaluation of coronary CT image blur using multi segment reconstruction algorithm. Methods: Cardiac motion was simulated in a Catphan. CT coronary angiography was performed using 320 × 0.5 mm detector array and 275 ms gantry rot…
View article: Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data
Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data Open
Objective To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups …
View article: Estimating GFR by Serum Creatinine, Cystatin C, and β2-Microglobulin in Older Adults: Results From the Canadian Study of Longevity in Type 1 Diabetes
Estimating GFR by Serum Creatinine, Cystatin C, and β2-Microglobulin in Older Adults: Results From the Canadian Study of Longevity in Type 1 Diabetes Open
Better estimates of GFR in older adults are needed for research and clinical practice, as this subgroup of the population has an amplified risk for the development of chronic kidney disease (CKD) that requires accurate GFR estimation metho…
View article: Follow‐Up of Incidental High‐Risk Pulmonary Nodules on Computed Tomography Pulmonary Angiography at Care Transitions
Follow‐Up of Incidental High‐Risk Pulmonary Nodules on Computed Tomography Pulmonary Angiography at Care Transitions Open
BACKGROUND Computed tomography pulmonary angiography (CTPA) detects incidental findings that require follow‐up. In just over 50% of cases, those incidental findings are pulmonary nodules. Fleischner guidelines recommend that patients with …
View article: Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes
Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes Open
Aims To examine the relationship between normal plasma uric acid (PUA) levels, renal haemodynamic function, arterial stiffness and plasma renin and aldosterone over a wide range of type 1 diabetes (T1D) durations in adolescents, young adul…
View article: Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes
Risk factors for diabetic kidney disease in adults with longstanding type 1 diabetes: results from the Canadian Study of Longevity in Diabetes Open
Objectives: Diabetic kidney disease (DKD) is an independent predictor of cardiovascular morbidity and mortality in type 1 diabetes (T1D). We aimed to explore clinical and biochemical factors, including the achievement of American Diabetes …
Enhanced pneumothorax visualization in ICU patients using portable chest radiography Open
Pneumothorax detection improves with novel enhancement software; the largest improvement is seen in less experienced readers.
View article: Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes
Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes Open
OBJECTIVE The importance of renin-angiotensin-aldosterone system (RAAS) activation in retinopathy for long-standing diabetes is not well understood. We determined retinopathy stage and evaluated associations with other vascular complicatio…
View article: Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes
Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes Open
OBJECTIVE Type 1 diabetes carries a significant risk for cardiovascular mortality, but it is unclear how atherosclerosis associates with microvascular complications. We aimed to determine the relationships between atherosclerotic burden an…
View article: Validity of a point-of-care nerve conduction device for polyneuropathy identification in older adults with diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes
Validity of a point-of-care nerve conduction device for polyneuropathy identification in older adults with diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes Open
The POCD has strong agreement and diagnostic accuracy for identification of polyneuropathy in a high-risk subgroup and thus may represent a sufficiently accurate and rapid test for routinely detecting those with electrophysiological dysfun…