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View article: A deep learning model for diagnosis of inherited retinal diseases
A deep learning model for diagnosis of inherited retinal diseases Open
To evaluate the performance of a multi-input deep learning (DL) model in detecting two common inherited retinal diseases (IRDs), i.e. retinitis pigmentosa (RP) and Stargardt disease (STGD), and differentiating them from healthy eyes. This …
View article: Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis
Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis Open
Treatment of posterior segment fibrosis is an unmet challenge in ophthalmology. Fibrotic responses complicate the pathology and treatment of age-related macular degeneration, diabetic retinopathy, retinal detachment, and other retinal dise…
View article: Uncovering the genetic architecture of inherited retinal disease in a consanguineous Iranian cohort
Uncovering the genetic architecture of inherited retinal disease in a consanguineous Iranian cohort Open
An integrated approach combining whole exome sequencing (WES) and autozygosity mapping was used to molecularly diagnose inherited retinal disease (IRD) in 192 unrelated Iranian families, 76.1% of which originate from a consanguineous backg…
View article: Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19
Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19 Open
Purpose: To report the coincidence of acute retinal necrosis (ARN) syndrome following acute meningoencephalitis and presumed coronavirus disease 2019 (COVID-19) in an immunocompetent patient. Case Report: A 58-year-old female presented to …
View article: Modification of a Selective NTRK2 Agonist and Confirmation of Activity in a Glaucoma-on-a-Chip Model
Modification of a Selective NTRK2 Agonist and Confirmation of Activity in a Glaucoma-on-a-Chip Model Open
Purpose: RNYK is a selective agonist of the neurotrophic tyrosine kinase receptor type 2 (NTRK2) which has been screened from a phage-displayed peptide library. Its sequence is SGVYKVAYDWQH, similar to a native NTRK2 ligand, that is, brain…
View article: Polymeric Propranolol Nanoparticles for Intraocular Delivery: Formulation, Characterization, and Vitreous Pharmacokinetics
Polymeric Propranolol Nanoparticles for Intraocular Delivery: Formulation, Characterization, and Vitreous Pharmacokinetics Open
Purpose: Recent studies have reported the promising effect of intravitreal propranolol on retinal neovascularization. However, rapid clearance and short half-life of the drug in the vitreous are the main drawbacks of this therapeutic appro…
View article: A health terminological system for inherited retinal diseases: Content coverage evaluation and a proposed classification
A health terminological system for inherited retinal diseases: Content coverage evaluation and a proposed classification Open
Purpose To present a classification of inherited retinal diseases (IRDs) and evaluate its content coverage in comparison with common standard terminology systems. Methods In this comparative cross-sectional study, a panel of subject matter…
View article: Choroidal structure investigated by choroidal vascularity index in patients with inherited retinal diseases
Choroidal structure investigated by choroidal vascularity index in patients with inherited retinal diseases Open
Purpose To evaluate the choroidal structure in patients with inherited retinal diseases (IRDs) by investigating the choroidal vascularity index (CVI). Methods The present study was conducted on 113 IRD patients and 113 sex- and age-matched…
View article: Effect of Music During General Anesthesia on Anesthetic Consumption During Vitrectomy Surgery
Effect of Music During General Anesthesia on Anesthetic Consumption During Vitrectomy Surgery Open
Background: Controversy remains about the positive role of music during general anesthesia and postoperative recovery. We, therefore, tested the hypothesis that intraoperative exposure to classical music reduces the propofol necessary to m…
View article: 1601 No increased risk of arrhythmia among patients with systemic lupus erythematosus or rheumatoid arthritis using hydroxychloroquine
1601 No increased risk of arrhythmia among patients with systemic lupus erythematosus or rheumatoid arthritis using hydroxychloroquine Open
Background Hydroxychloroquine (HCQ) is a cornerstone medication for the treatment and management of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other autoimmune rheumatic diseases. Previous studies have found an asso…
View article: The Inhibitory Effect of Connective Tissue Growth Factor Antibody on Postoperative Fibrosis in a Rabbit Model of Trabeculectomy
The Inhibitory Effect of Connective Tissue Growth Factor Antibody on Postoperative Fibrosis in a Rabbit Model of Trabeculectomy Open
Purpose: To compare the efficacy of subconjunctival injection of an anti-connective tissue growth factor antibody (anti-CTGF) versus mitomycin-C (MMC) and placebo in reducing scar formation in a rabbit model of trabeculectomy. Methods: A t…
View article: Identification of three novel homozygous variants in COL9A3 causing autosomal recessive Stickler syndrome
Identification of three novel homozygous variants in COL9A3 causing autosomal recessive Stickler syndrome Open
View article: RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort study
RetINal Toxicity And HydroxyChloroquine Therapy (INTACT): protocol for a prospective population-based cohort study Open
Purpose Hydroxychloroquine (HCQ) is an important medication for patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other rheumatic diseases. Although it is well-tolerated and cost-effective, the risk of HCQ ret…
View article: Vision-Related Quality of Life in Patients with Inherited Retinal Dystrophies
Vision-Related Quality of Life in Patients with Inherited Retinal Dystrophies Open
Purpose: To evaluate the effect of inherited retinal dystrophies (IRDs) on vision-related quality of life (VRQoL) among IRDs' patients in Iran. Methods: This cross-sectional study was conducted on 192 patients with different types of IRDs …
View article: Unraveling the genetic complexities of combined retinal dystrophy and hearing impairment
Unraveling the genetic complexities of combined retinal dystrophy and hearing impairment Open
View article: Identification of three novel homozygous variants in COL9A3 causing autosomal-recessive Stickler Syndrome
Identification of three novel homozygous variants in COL9A3 causing autosomal-recessive Stickler Syndrome Open
Background: Stickler syndrome (STL) is a rare, clinically and molecularly heterogeneous connective tissue disorder. Pathogenic variants occurring in a variety of genes cause STL, mainly inherited in an autosomal dominant fashion. Autosomal…
View article: Autosomal Recessive Bestrophinopathy: Clinical and Genetic Characteristics of Twenty-Four Cases
Autosomal Recessive Bestrophinopathy: Clinical and Genetic Characteristics of Twenty-Four Cases Open
Background. To describe ocular manifestations, imaging characteristics, and genetic test results of autosomal recessive bestrophinopathy (ARB). The study design is an observational case series. Methods. Forty-eight eyes of 24 patients diag…
View article: Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography
Retinal Vascular Abnormalities in Different Types of Inherited Retinal Dystrophies Assessed by Optical Coherence Tomography Angiography Open
Purpose: To investigate the retinal vascular characteristics among patients with different types of inherited retinal dystrophies (IRDs). Methods: This comparative cross-sectional study was conducted on 59 genetically confirmed cases of IR…
View article: Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration
Susceptible Single Nucleotide Polymorphisms in Exon 10 and Intron 9 of Complement Factor H Gene in Patients With Age-related Macular Degeneration Open
Background: Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly. Although it has been shown that Y402H polymorphism in the CFH gene was strongly associated with AMD in the Iranian population, there wer…
View article: A lab‐on‐a‐chip model of glaucoma
A lab‐on‐a‐chip model of glaucoma Open
Aims We developed a glaucoma‐on‐a‐chip model to evaluate the viability of retinal ganglion cells (RGCs) against high pressure and the potential effect of neuroprotection. Methods A three‐layered chip consisting of interconnecting microchan…
View article: Varicella Zoster Virus Induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19
Varicella Zoster Virus Induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19 Open
Background : To report the coincidence of acute retinal necrosis syndrome (ARN) following acute meningoencephalitis and presumed coronavirus disease 2019 (COVID-19) in an immunocompetent patient. Case presentation: A 58-year old female pre…
View article: Choroidal Thickness in Different Types of Inherited Retinal Dystrophies
Choroidal Thickness in Different Types of Inherited Retinal Dystrophies Open
Purpose: To compare the choroidal thickness among eyes with retinitis pigmentosa (RP), Stargardt disease, Usher syndrome, cone-rod dystrophy, and healthy eyes of sex- and age-matched individuals. Methods: In this comparative study, 503 eye…
View article: The First Inherited Retinal Disease Registry in Iran: Research Protocol and Results of a Pilot Study
The First Inherited Retinal Disease Registry in Iran: Research Protocol and Results of a Pilot Study Open
Background: To describe the protocol for developing a national inherited retinal disease (IRD) registry in Iran and present its initial report. Methods: This community-based participatory research was approved by the Ministry of Health and…
View article: Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age‐related macular degeneration
Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age‐related macular degeneration Open
Macrophages are the main infiltrating immune cells in choroidal neovascularization (CNV), a hallmark of the human wet, or neovascular age‐related macular degeneration (AMD). Due to their plasticity and ability to adapt to the local microen…
View article: PRPF31 reduction causes mis-splicing of the phototransduction genes in human organotypic retinal culture
PRPF31 reduction causes mis-splicing of the phototransduction genes in human organotypic retinal culture Open
View article: Incidence and risk factors of retinopathy of prematurity and utility of the national screening criteria in a tertiary center in Iran
Incidence and risk factors of retinopathy of prematurity and utility of the national screening criteria in a tertiary center in Iran Open
ROP incidence is relatively high in Iran. Identifying ROP risk factors results in more accurate screening and reduces the risk of irreversible vision loss. The ROP screening criteria utilized in Iran are efficient at the present time.
View article: Effects of Intravitreal Connective Tissue Growth Factor Neutralizing Antibody on the Epiretinal Membrane Formation; an Experimental Study
Effects of Intravitreal Connective Tissue Growth Factor Neutralizing Antibody on the Epiretinal Membrane Formation; an Experimental Study Open
View article: Intravitreal Connective Tissue Growth Factor Neutralizing Antibody Reduces Subretinal Fibrosis Associated with Experimental Choroidal Neovascular Membrane
Intravitreal Connective Tissue Growth Factor Neutralizing Antibody Reduces Subretinal Fibrosis Associated with Experimental Choroidal Neovascular Membrane Open
View article: A lab-on-a-chip model of glaucoma
A lab-on-a-chip model of glaucoma Open
We developed a glaucoma-on-a-chip (GOC) model to evaluate the viability of retinal ganglion cells (RGCs) against high pressure and the potential effect of neuroprotection. A three-layered chip consisting of interconnecting microchannels an…
View article: Generation of Retinal Pigmented Epithelium-Like Cells from Pigmented Spheres Differentiated from Bone Marrow Stromal Cell-Derived Neurospheres
Generation of Retinal Pigmented Epithelium-Like Cells from Pigmented Spheres Differentiated from Bone Marrow Stromal Cell-Derived Neurospheres Open