Naser F. Al‐Tannak
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View article: Stability-Indicating Assay of Novel 5-(Hydroxamic acid)methyl Oxazolidinones with 5-Lipooxygenase Inhibitory Activity
Stability-Indicating Assay of Novel 5-(Hydroxamic acid)methyl Oxazolidinones with 5-Lipooxygenase Inhibitory Activity Open
Background: Oxazolidinone derivatives are a novel class of synthetic antibacterial agents, characterized by a five-membered heterocyclic ring containing oxygen and nitrogen and a carbonyl functionality at position 2. This pharmacophore is …
View article: LC-MS/MS Method Development and Validation for Clinical Pharmacokinetics and Therapeutic Drug Monitoring of Potassium-Competitive Acid Blocker Vonoprazan-Based Triple Therapy for H. pylori in Human Plasma
LC-MS/MS Method Development and Validation for Clinical Pharmacokinetics and Therapeutic Drug Monitoring of Potassium-Competitive Acid Blocker Vonoprazan-Based Triple Therapy for H. pylori in Human Plasma Open
Background: A novel triple therapy regimen for Helicobacter pylori eradication, recently approved by the U.S. FDA, comprises vonoprazan (VPN), a potassium-competitive acid blocker, in combination with amoxicillin (AMX) and clarithromycin (…
View article: Development and Validation of an LC-MS/MS Method for the Simultaneous Determination of Alprazolam, Bromazepam, Clonazepam, Diazepam and Flunitrazpam in Human Urine and Its Application to Samples from Suspected Drug Abusers
Development and Validation of an LC-MS/MS Method for the Simultaneous Determination of Alprazolam, Bromazepam, Clonazepam, Diazepam and Flunitrazpam in Human Urine and Its Application to Samples from Suspected Drug Abusers Open
A simple and reliable method was developed using LC-MS/MS to quantify alprazolam, bromazepam, clonazepam, diazepam, and flunitrazepam in clinical samples. This method was validated for the simultaneous determination of alprazolam, bromazep…
View article: Bioactivity-guided fractionation of Withania somnifera (L.) Dunal roots extract: evaluation of the anti-progressive potential on human Kelly neuroblastoma cell line
Bioactivity-guided fractionation of Withania somnifera (L.) Dunal roots extract: evaluation of the anti-progressive potential on human Kelly neuroblastoma cell line Open
Not applicable.
View article: A review on recent insights on cardiovascular diseases drug design using natural products and in silico studies
A review on recent insights on cardiovascular diseases drug design using natural products and in silico studies Open
Cardiovascular diseases (CVDs), which are among the leading causes of morbidity and mortality, are strongly associated with unhealthy eating habits. Compounds originating from plants, natural products, and balanced diets have been identifi…
View article: Greenness Assessment and Development of an Innovative HPLC Method for the Determination of Rifaximin and Sodium Benzoate in Oral Suspension
Greenness Assessment and Development of an Innovative HPLC Method for the Determination of Rifaximin and Sodium Benzoate in Oral Suspension Open
The pharmaceutical industry has brought advancement and opportunities. However, it has also presented challenges and complexity that must be addressed. The pharmaceutical industry aims to protect public health by providing economical, effe…
View article: Quantitative analysis of mixed lipid nanostructures in rat skin by HPLC-MS
Quantitative analysis of mixed lipid nanostructures in rat skin by HPLC-MS Open
Liquid chromatography-mass spectrometry (LC-MS) is a very sensitive technique for determining small concentrations of drugs in fixed dose combinations or even those deposited in skin layers. Therefore, an LC-MS method was applied for deter…
View article: Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of <i>Vachellia nilotica</i>
Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of <i>Vachellia nilotica</i> Open
A new labdane diterpene characterized as 18α- O - trans - p -feruloyl-15-methyl-8(17)-labdanoate has been isolated from the roots of Vachellia nilotica . Also isolated were p -coumaric acid, ferulic acid, stearic acid, lupeol, and a mixtur…
View article: A New Isoflavone from Lomariopsis guineensis (Underw.) Alston
A New Isoflavone from Lomariopsis guineensis (Underw.) Alston Open
Aim/background: Lomariopsis guineensis (Underw.) Alston is an epiphytic climbing fern. It is widely distributed in Africa where it is also used in traditional medicine and as food. There are no previous reports of any constituents of the p…
View article: Eco-friendly HPLC method by using response surface design to measure a combination of three antidiabetic drugs
Eco-friendly HPLC method by using response surface design to measure a combination of three antidiabetic drugs Open
In recent years, there has been a significant increase in the application of green chemistry principles in analytical chemistry. One of the key factors affecting the environmental sustainability of analytical methods is the choice of solve…
View article: Green chemistry and its implementation in pharmaceutical analysis
Green chemistry and its implementation in pharmaceutical analysis Open
The expanding progression of industrial development has been a pioneer for world economic growth. Green chemistry has been defined as ‘the employment of techniques and methodologies that reduce or eliminate the use or production of feedsto…
View article: Quality by Design Approach for a Multicomponent Quantification Using HPLC-PDA and HPLC-MS: Application to Dosage Form and Biological Body Fluids
Quality by Design Approach for a Multicomponent Quantification Using HPLC-PDA and HPLC-MS: Application to Dosage Form and Biological Body Fluids Open
A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated and quantified in the dosage form on a C-18 column using a gradient mobile pha…
View article: Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids Open
The relationship between nutrient starvation and mitochondrial dynamics is poorly understood. We find that cells facing amino acid starvation display clear mitochondrial fusion as a means to evade mitophagy. Surprisingly, further supplemen…
View article: Development and Validation of Stability-Indicating Assay Method for a Novel Oxazolidinone (PH-192) with Anticonvulsant Activity by Using UHPLC-QToF-MS
Development and Validation of Stability-Indicating Assay Method for a Novel Oxazolidinone (PH-192) with Anticonvulsant Activity by Using UHPLC-QToF-MS Open
The treatment of seizure disorders with currently available pharmacotherapeutic agents is not optimal due to the failure of some patients to respond, coupled with occurrences of side effects. There is therefore a need for research into the…
View article: Eco-Friendly Separation of Antihyperlipidemic Combination Using UHPLC Particle-Packed and Monolithic Columns by Applying Green Analytical Chemistry Principles
Eco-Friendly Separation of Antihyperlipidemic Combination Using UHPLC Particle-Packed and Monolithic Columns by Applying Green Analytical Chemistry Principles Open
Efficient separation of pharmaceuticals and metabolites with the adequate resolution is a key factor in choosing the most suitable chromatographic method. For quality control, the analysis time is a key factor, especially in pharmacokineti…
View article: Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents
Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents Open
By December 2019, humanity was challenged by a new infectious respiratory disease named coronavirus disease of 2019 or COVID-19. This is a viral infection based on the presence of the previously non-problematic coronavirus with assigned nu…
View article: LC-MS Method for the Detection and Quantification of Ursolic Acid and Uvaol Levels in Olive Leaves and Oregano
LC-MS Method for the Detection and Quantification of Ursolic Acid and Uvaol Levels in Olive Leaves and Oregano Open
Ursolic acid and uvaol belong to pentacyclic triterpenes are both secondary metabolites with significant biological activity. Ursolic acid and uvaol are exist in many natural matrices such as olive leaves, oregano and thymus. Therefore, a …
View article: Remdesivir—Bringing Hope for COVID-19 Treatment
Remdesivir—Bringing Hope for COVID-19 Treatment Open
At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (…
View article: Stockpiling by pups and self-sacrifice by their fasting mothers observed in birth to weaning serum metabolomes of Atlantic grey seals
Stockpiling by pups and self-sacrifice by their fasting mothers observed in birth to weaning serum metabolomes of Atlantic grey seals Open
During the uniquely short lactations of true seals, pups acquire a greater proportion of maternal body resources, at a greater rate, than in any other group of mammals. Mothers in many species enter a period of anorexia but must preserve s…
View article: Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study Open
South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (as…
View article: Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma:<i> Clinical Application to Therapeutic Drug Monitoring</i>
Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma:<i> Clinical Application to Therapeutic Drug Monitoring</i> Open
A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni ® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal…
View article: UHPLC-UV Method for Simultaneous Determination of Perindopril Arginine and Indapamide Hemihydrate in Combined Dosage Form: A Stability-Indicating Assay Method
UHPLC-UV Method for Simultaneous Determination of Perindopril Arginine and Indapamide Hemihydrate in Combined Dosage Form: A Stability-Indicating Assay Method Open
Perindopril arginine and Indapamide hemihydrate in combination were proven to have a synergistic antihypertensive impact when compared with the use of each component alone. Therefore, a new Ultra-High Performance Liquid Chromatography coup…
View article: Antimycobacterial Activities of N-Substituted-Glycinyl 1H-1,2,3-Triazolyl Oxazolidinones and Analytical Method Development and Validation for a Representative Compound
Antimycobacterial Activities of N-Substituted-Glycinyl 1H-1,2,3-Triazolyl Oxazolidinones and Analytical Method Development and Validation for a Representative Compound Open
Twelve N-substituted-glycinyl triazolyl oxazolidinone derivatives were screened for antimycobacterial activity against susceptible (Mycobacterium tuberculosis (Mtb) H37Rv) and resistant (isoniazid (INH)-resistant Mtb (SRI 1369), rifampin (…
View article: Protein synthesis inhibitors of natural origin for CML therapy: semisynthetic homoharringtonine (Omacetaxine mepesuccinate)
Protein synthesis inhibitors of natural origin for CML therapy: semisynthetic homoharringtonine (Omacetaxine mepesuccinate) Open
Omacetaxine mepesuccinate is a drug approved in 2014 by FDA for the use in CML therapy in patients resistant to at least two thymidine kinase inhibitors (TKIs). It possesses unique mechanism of anticancer activity that is principally diffe…