Nasim Hayati Roodbari
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View article: Prenatal exposure to a single dose of testosterone adversely affects the oocyte and embryo quality in rats during adulthood: An experimental study
Prenatal exposure to a single dose of testosterone adversely affects the oocyte and embryo quality in rats during adulthood: An experimental study Open
Background: Prenatal exposure to excess androgen can adversely affect the hypothalamic-pituitary-ovarian axis in the developing fetus, potentially leading to long-term reproductive system dysfunction in later life. Objective: We aimed to i…
View article: Eugenol Reduces Oxidative Stress and Modulates BAX/ BCL-2 in Testes of Diabetic Rats
Eugenol Reduces Oxidative Stress and Modulates BAX/ BCL-2 in Testes of Diabetic Rats Open
Objectives: Diabetes is a prevalent and chronic condition that has been found to have adverse effects on male fertility. Recent studies have explored the potential of eugenol in preventing diabetes-related complications. This research aime…
View article: Exosomes from miR-149-3p-transfected menstrual blood-derived mesenchymal stem cells ameliorate inflammation and migration of endometriosis cells.
Exosomes from miR-149-3p-transfected menstrual blood-derived mesenchymal stem cells ameliorate inflammation and migration of endometriosis cells. Open
The potential of exosomes as miRNA carriers could be considered in developing novel endometriosis therapies.
View article: Biosynthesis of cobalt oxide nanoparticles and their cytotoxicity against cancer cells mouse colon adenocarcinoma cell line
Biosynthesis of cobalt oxide nanoparticles and their cytotoxicity against cancer cells mouse colon adenocarcinoma cell line Open
The application of plant extracts for the biosynthesis of cobalt oxide nanoparticles is eco-friendly, more economical, less toxic, and more biocompatible. In this study, we used Rose hip extract to synthesize cobalt oxide nanoparticles (Co…
View article: Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate
Nutritional Value of Palm Meristem from Phoenix dactylifera L. and Its Effect on Polycystic Ovary Syndrome in Female Rats Induced with Estradiol Valerate Open
Objective: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. The objective of our investigation is to study the protective effect of hydroethanolic extract of palm meristem (HEPM) on fe…
View article: Fortified electrospun collagen utilizing biocompatible Poly Glycerol Sebacate prepolymer (PGSp) and zink oxide nanoparticles (ZnO NPs) for diabetics wound healing: Physical, biological and animal studies
Fortified electrospun collagen utilizing biocompatible Poly Glycerol Sebacate prepolymer (PGSp) and zink oxide nanoparticles (ZnO NPs) for diabetics wound healing: Physical, biological and animal studies Open
View article: <i>In vitro</i> pro-apoptotic and anti-metastatic potentials of harmaline-silver containing folate-linked chitosan nano-drug delivery system.
<i>In vitro</i> pro-apoptotic and anti-metastatic potentials of harmaline-silver containing folate-linked chitosan nano-drug delivery system. Open
The cancer-selective cytotoxicity, apoptotic, and anti-metastatic properties of HA-fCNP are considered the appropriate properties of an anticancer compound.
View article: Impact of DNA methylation of the human mesoderm-specific transcript (MEST) on male infertility
Impact of DNA methylation of the human mesoderm-specific transcript (MEST) on male infertility Open
Male infertility accounts for nearly 40%-50% of all infertile cases. One of the most prevalent disorders detected in infertile men is errors in the MEST differentially methylated region (DMR), which has been correlated with poor sperm inde…
View article: Protective Effect of Docetaxel Against Autophagy-Related Genes in Vitrification of Mouse Metaphase II Oocytes.
Protective Effect of Docetaxel Against Autophagy-Related Genes in Vitrification of Mouse Metaphase II Oocytes. Open
Incubation of mouse metaphase II oocytes with docetaxel prior to vitrification reduced the expression of autophagy-related genes and increased survival and fertilization rates compared to untreated oocytes.
View article: Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study.
Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study. Open
Hepatotoxicity in Iranian patients with tuberculosis was confirmed due to the presence of NAT2 SA polymorphism. Determining NAT2 and CYP2E1 genotypes and/or INH concentration can be a valuable tool to identify patients…
View article: Investigating the anticancer and anti-angiogenic effects of graphene oxide nanoparticles containing 6-gingerol modified with chitosan and folate
Investigating the anticancer and anti-angiogenic effects of graphene oxide nanoparticles containing 6-gingerol modified with chitosan and folate Open
Objective The use of nanocarriers to improve the targeting of treatment plays a key role in the treatment of many diseases, including cancer. This study was carried out to synthesize graphene oxide (GO) containing 6-gingerol (Ging) modifie…
View article: Study of Protective Effects of Palm Meristem's Hydroalcholic Extract on Polycystic Ovary Syndrome in Rats Induced with Estradiol Valerate
Study of Protective Effects of Palm Meristem's Hydroalcholic Extract on Polycystic Ovary Syndrome in Rats Induced with Estradiol Valerate Open
Study of Protective Effects of Palm Meristem's Hydroalcholic Extract on Polycystic Ovary Syndrome in Rats Induced with Estradiol Valerate
View article: Histopathological changes of spermatogenesis induced by Intra-peritoneal injection of CuO nanoparticles
Histopathological changes of spermatogenesis induced by Intra-peritoneal injection of CuO nanoparticles Open
A number of lifestyle-related factors, including smoking and obesity, as well as a number of environmental factors, such as exposure to dioxins, combustion products, and traffic exhaust gases, appear to have a deleterious influence on the …
View article: Prenatal kisspeptin antagonist exposure prevents polycystic ovary syndrome development in prenatally-androgenized rats in adulthood: An experimental study
Prenatal kisspeptin antagonist exposure prevents polycystic ovary syndrome development in prenatally-androgenized rats in adulthood: An experimental study Open
Background: Increased levels of kisspeptin are associated with hypothalamus-pituitary- ovary axis dysfunction. It may lead to the development of polycystic ovary syndrome (PCOS). Objective: We aimed to investigate the effect of prenatal ki…
View article: Treatment with quercetin increases Nrf2 expression and neuronal differentiation of sub ventricular zone derived neural progenitor stem cells in adult rats.
Treatment with quercetin increases Nrf2 expression and neuronal differentiation of sub ventricular zone derived neural progenitor stem cells in adult rats. Open
Background The presence of neural precursor stem cells in some parts of the adult brain has been proven in recent years, and it has opened up a new approach for the treatment and recovery of the defects and diseases associated with the cen…
View article: Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats
Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats Open
One of the main health concerns of diabetes is testicular dysfunction and impairment of reproductive function and sperm quality which can cause male infertility. kisspeptin is a hypothalamic neuropeptide hormone that is involved in the reg…
View article: Treatment with quercetin increases Nrf2 expression and neuronal differentiation of SVZ-derived NPSCs.
Treatment with quercetin increases Nrf2 expression and neuronal differentiation of SVZ-derived NPSCs. Open
The presence of neural precursor stem cells (NPSCs) in some parts of the adult brain has been proven in recent years, and it has opened up a new approach for the treatment and recovery of the defects and diseases associated with the centra…
View article: Differentiation of Alginate-Encapsulated Wharton Jelly-Derived Mesenchymal Stem Cells into Insulin Producing Cells.
Differentiation of Alginate-Encapsulated Wharton Jelly-Derived Mesenchymal Stem Cells into Insulin Producing Cells. Open
Objective: Insulin insufficiency due to the reduced pancreatic beta cell number is the hallmark of diabetes, resulting inan intense focus on the development of beta-cell replacement options. One approach to overcome the pr…
View article: Anti-tumor Effect of the Ethanolic Extract of Vinca herbacea on Human Breast Cancer Cell Line: A Mechanism Study
Anti-tumor Effect of the Ethanolic Extract of Vinca herbacea on Human Breast Cancer Cell Line: A Mechanism Study Open
Background: Breast cancer is extensively studied for its resistance to chemotherapy. Therefore, finding efficient therapeutic agents is vital to increasing the survival rate of patients. Objective: Here, we conducted an in vitro study on t…
View article: Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6
Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6 Open
Amyloidosis is a heterogeneous group of protein deposition diseases associated with the presence of amyloid fibrils in tissues. Analogs of insulin that are used for treating diabetic patients (including regular insulin) can form amyloid fi…
View article: Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats
Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats Open
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong link between hyperglycemia, oxidative stress, inflammation, and the development of diabetes mellitus. PI3K/Akt/mTOR is the main signaling pa…
View article: Evaluation of different strain mice during in vitro fertilization and embryo development in response to superovulation
Evaluation of different strain mice during in vitro fertilization and embryo development in response to superovulation Open
Evaluation of different strain mice during in vitro fertilization and embryo development in response to superovulation
View article: The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold
The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold Open
The effect of cerebrospinal fluid-derived exosomes on neural differentiation of adipose mesenchymal stem cells in alginate hydrogel scaffold
View article: Effects of Levofloxacin on Expression of Apoptosis Genes of Ovarian Follicles in NMRI Mouse in Vitro and in Vivo
Effects of Levofloxacin on Expression of Apoptosis Genes of Ovarian Follicles in NMRI Mouse in Vitro and in Vivo Open
Background and Objectives: Levofloxacin is a fluoroquinolone. Long-term use of antibiotics, including fluoroquinolone antibiotics, causes dystrophic changes in the ovaries. In this study, the effects of levofloxacin on the development of o…
View article: Forced Suppression of let-7a-5p in Mouse Blastocysts Improves Implantation Rate
Forced Suppression of let-7a-5p in Mouse Blastocysts Improves Implantation Rate Open
Background Embryo implantation requires appropriate communication between the blastocyst and endometrium. Recurrent implantation failure is an essential component of assisted reproductive technology. Also, miRNAs-mediated gene expression i…
View article: Assessment of Antitumor Activity of Vinca herbacea on Human Ovarian Cancer Cell Line
Assessment of Antitumor Activity of Vinca herbacea on Human Ovarian Cancer Cell Line Open
Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials …
View article: The Effect of N-Acetyl-Cysteine on <i>NRF2</i> Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study.
The Effect of N-Acetyl-Cysteine on <i>NRF2</i> Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study. Open
The results demonstrated that NAC oral supplementation protected against oxidative stress by enhancing NRF2 expression. This could improve semen parameters quality parameters in asthenoteratozoospermia men (Registration number: IRCT2017083…
View article: Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ-Irradiated Mice.
Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ-Irradiated Mice. Open
Supplementation of human ovarian tissue culture medium with LPA improves follicular survival and development by promoting an anti-apoptotic balance in transcription of BCL2 and BAX genes.
View article: Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes.
Association of rs11558471 in SLC30A8 Gene with Interleukin 17 Serum Levels and Insulin Resistance in Iranian Patients with Type 2 Diabetes. Open
The present study demonstrated for the first time, the genetic association of rs11558471 with IL-17 and glycemic traits in Iranian patients with T2D. The association of rs11558471 with glycemic traits showed that it might be useful for the…
View article: Impact of coadministration of apigenin and bone marrow stromal cells on damaged ovaries due to chemotherapy in rat: An experimental study
Impact of coadministration of apigenin and bone marrow stromal cells on damaged ovaries due to chemotherapy in rat: An experimental study Open
Background: Apigenin is a plant-derived flavonoid with antioxidative and antiapoptotic effects. Bone marrow stromal cells (BMSCs) are a type of mesenchymal stem cells (MSCs) that may recover damaged ovaries. It seems that apigenin may prom…