Nasim Sheikh‐Bahaei
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View article: The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease
The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease Open
View article: The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease
The Curious Case of a Heterozygous Loss-of-Function PSEN1 variant associated with Early-Onset Alzheimer’s Disease Open
Background Over 300 mutations in PSEN1 have been identified as causes of early-onset Alzheimer’s disease (EOAD). While these include missense mutations and a few insertions, deletions, or duplications, none result in open reading frame shi…
View article: Advancing 1.5T MR imaging: toward achieving 3T quality through deep learning super-resolution techniques
Advancing 1.5T MR imaging: toward achieving 3T quality through deep learning super-resolution techniques Open
Introduction A 3T MRI scanner delivers enhanced image quality and SNR, minimizing artifacts to provide superior high-resolution brain images compared to a 1.5T MRI. Thus, making it vitally important for diagnosing complex neurological cond…
View article: Diffusion based multi-domain neuroimaging harmonization method with preservation of anatomical details
Diffusion based multi-domain neuroimaging harmonization method with preservation of anatomical details Open
View article: Interleaved flow‐sensitive dephasing (<scp>iFSD</scp>): Toward enhanced blood flow suppression and preserved <scp>T<sub>1</sub></scp> weighting and overall signals in <scp>3D TSE</scp>‐based neuroimaging
Interleaved flow‐sensitive dephasing (<span>iFSD</span>): Toward enhanced blood flow suppression and preserved <span>T<sub>1</sub></span> weighting and overall signals in <span>3D TSE</span>‐based neuroimaging Open
Purpose To develop and validate a 3D turbo spin‐echo (TSE)–compatible approach to enhancing black‐blood (BB) effects while preserving T 1 weighting and overall SNR. Methods Following the excitation RF pulse, a 180° RF pulse sandwiched by a…
View article: Unusually young onset of spastic paraparesis in a carrier of both the A431E PSEN1 and A713T APP variants
Unusually young onset of spastic paraparesis in a carrier of both the A431E PSEN1 and A713T APP variants Open
Background The ways in which diverse genetic variants interact to affect the phenotype of AD is poorly understood. The relatively consistent phenotype associated with specific mutations causing autosomal dominant AD (ADAD) provides the opp…
View article: The effect of traumatic brain injury and post‐traumatic stress disorders on AD pathologies, small vessel changes and ultimately cognitive function
The effect of traumatic brain injury and post‐traumatic stress disorders on AD pathologies, small vessel changes and ultimately cognitive function Open
Background Although many studies have shown that traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) regardless of their severity, are associated with a significantly increased risk of all‐cause dementia, the specific pa…
View article: Perivascular Space Analysis: A Possible Tool for Predicting Cerebral Amyloid Angiopathy in Pathology‐Confirmed Cases
Perivascular Space Analysis: A Possible Tool for Predicting Cerebral Amyloid Angiopathy in Pathology‐Confirmed Cases Open
Background Diagnosis of cerebral amyloid angiopathy (CAA) presents a significant challenge in determining whether to propose anti‐amyloid treatment plans. The identification of perivascular spaces (PVS) through MRI serves as a possible str…
View article: Perivascular Space Analysis: A Possible Tool for Predicting Cerebral Amyloid Angiopathy in Pathology‐Confirmed Cases
Perivascular Space Analysis: A Possible Tool for Predicting Cerebral Amyloid Angiopathy in Pathology‐Confirmed Cases Open
Background Diagnosis of cerebral amyloid angiopathy (CAA) presents a significant challenge in determining whether to propose anti‐amyloid treatment plans. The identification of perivascular spaces (PVS) through MRI serves as a possible str…
View article: The effect of traumatic brain injury and post‐traumatic stress disorders on AD pathologies, small vessel changes and ultimately cognitive function
The effect of traumatic brain injury and post‐traumatic stress disorders on AD pathologies, small vessel changes and ultimately cognitive function Open
Background Although many studies have shown that traumatic brain injury (TBI) and post‐traumatic stress disorder (PTSD) regardless of their severity, are associated with a significantly increased risk of all‐cause dementia, the specific pa…
View article: Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment
Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment Open
Background Perivascular spaces (PVS) are fluid-filled spaces surrounding the brain parenchymal vasculature. Literature suggests that PVS may play a significant role in aging and neurological disorders, including Alzheimer’s disease (AD). T…
View article: Diffusion based multi-domain neuroimaging harmonization method with preservation of anatomical details
Diffusion based multi-domain neuroimaging harmonization method with preservation of anatomical details Open
Multi-center neuroimaging studies face technical variability due to batch differences across sites, which potentially hinders data aggregation and impacts study reliability.Recent efforts in neuroimaging harmonization have aimed to minimiz…
View article: Deep learning for the harmonization of structural MRI scans: a survey
Deep learning for the harmonization of structural MRI scans: a survey Open
Medical imaging datasets for research are frequently collected from multiple imaging centers using different scanners, protocols, and settings. These variations affect data consistency and compatibility across different sources. Image harm…
View article: Prediction of future dementia among patients with mild cognitive impairment (MCI) by integrating multimodal clinical data
Prediction of future dementia among patients with mild cognitive impairment (MCI) by integrating multimodal clinical data Open
View article: Prediction of Future Dementia Among Patients with Mild Cognitive Impairment (MCI) by Integrating Multimodal Clinical Data
Prediction of Future Dementia Among Patients with Mild Cognitive Impairment (MCI) by Integrating Multimodal Clinical Data Open
View article: Correction to: Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease
Correction to: Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease Open
View article: Characterizing cerebral microhemorrhage associations in dementia subtypes in the UK Biobank
Characterizing cerebral microhemorrhage associations in dementia subtypes in the UK Biobank Open
Background Cerebral microbleeds (CMBs) are associated with neurodegenerative diseases (Charidimou, 2011) and have been identified as an adverse amyloid‐related imaging abnormality event (ARIA‐H) related to amyloid clearing medications (Spe…
View article: Prediction of future dementia for MCI patients using a novel multimodal machine learning framework
Prediction of future dementia for MCI patients using a novel multimodal machine learning framework Open
Background Prediction of future dementia for patients with mild cognitive impairment (MCI) is a significant clinical goal, so that the identified cases can benefit from treatments. Currently, the clinical standard for diagnosing dementia u…
View article: Cerebral microhemorrhage associations in UK immigrants from the Middle East and North Africa (MENA)
Cerebral microhemorrhage associations in UK immigrants from the Middle East and North Africa (MENA) Open
Background People from the Middle East and North Africa (MENA) are highly underrepresented in health studies, yet, they are forecasted to contribute the most to increasing projections of dementia over the next 30 years (Nichols, 2022). Cer…
View article: Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes
Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes Open
Migraine is a complex and heterogenous disorder whose disease mechanisms remain disputed. This narrative review summarizes functional MRI (fMRI) and diffusion tensor imaging (DTI) findings and interprets their association with migraine sym…
View article: Perivascular spaces in Alzheimer’s disease are associated with inflammatory, stress-related, and hypertension biomarkers
Perivascular spaces in Alzheimer’s disease are associated with inflammatory, stress-related, and hypertension biomarkers Open
Perivascular spaces (PVS) are fluid-filled spaces surrounding the brain vasculature. Literature suggests that PVS may play a significant role in aging and neurological disorders, including Alzheimer’s disease (AD). Cortisol, a stress hormo…
View article: Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma
Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma Open
Migraine is a complex and common disorder that affects patients around the world. Despite recent advances in this field, the exact pathophysiology of migraine is still not completely understood. Structural MRI sequences have revealed a var…
View article: Arterial Spin Labeling in Migraine: A Review of Migraine Categories and Mimics
Arterial Spin Labeling in Migraine: A Review of Migraine Categories and Mimics Open
Migraine is a complex headache characterized by changes in functional connectivity and cerebral perfusion. The perfusion changes represent a valuable domain for targeted drug therapy. Arterial spin labeling is a noncontrast imaging techniq…
View article: Characterization of spastic paraplegia in a family with a novel<i>PSEN1</i>mutation
Characterization of spastic paraplegia in a family with a novel<i>PSEN1</i>mutation Open
Spastic paraparesis has been described to occur in 13.7% of PSEN1 mutations and can be the presenting feature in 7.5%. In this paper, we describe a family with a particularly young onset of spastic paraparesis due to a novel mutation in PS…
View article: Late Age of Onset Predicted by Aβ Profiling in a Novel Psen1 (I180f) Mutation
Late Age of Onset Predicted by Aβ Profiling in a Novel Psen1 (I180f) Mutation Open
View article: WHITE MATTER CHANGE NEAR CEREBRAL MICROBLEEDS AFTER MTBI INVOLVES AGE AND SEX DEPENDENT COGNITIVE DECLINE
WHITE MATTER CHANGE NEAR CEREBRAL MICROBLEEDS AFTER MTBI INVOLVES AGE AND SEX DEPENDENT COGNITIVE DECLINE Open
We tested the null hypothesis that, after mild traumatic brain injury (mTBI), white matter changes near cerebral microbleeds (CMBs) are associated with cognitive decline. Magnetic resonance images were acquired from 62 adults with mTBI and…
View article: White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury
White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury Open
View article: Dementia is associated with medial temporal atrophy even after accounting for neuropathologies
Dementia is associated with medial temporal atrophy even after accounting for neuropathologies Open
Brain atrophy is associated with degenerative neuropathologies and the clinical status of dementia. Whether dementia is associated with atrophy independent of neuropathologies is not known. In this study, we examined the pattern of atrophy…
View article: Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury
Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury Open
View article: Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists
Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists Open
Medications for type 2 diabetes (T2DM) offer a promising path for discovery and development of effective interventions for dementia syndromes. A common feature of dementia syndromes is an energy failure due to reduced energy supply to neur…