J. Goldstein
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View article: BoltzGen: Toward Universal Binder Design
BoltzGen: Toward Universal Binder Design Open
We introduce BoltzGen , an all-atom generative model for designing proteins and peptides across all modalities to bind a wide range of biomolecular targets. BoltzGen builds strong structural reasoning capabilities about target-binder inter…
View article: Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, <scp>CDX</scp> ‐622
Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, <span>CDX</span> ‐622 Open
Background Mast cells (MCs) respond to an array of allergens that drive allergic and inflammatory diseases. Stem cell factor (SCF), the ligand for the receptor KIT, is required for MC survival and function. Thymic stromal lymphopoietin (TS…
View article: Latest results from the RD42 collaboration on the radiation tolerance of polycrystalline diamond detectors
Latest results from the RD42 collaboration on the radiation tolerance of polycrystalline diamond detectors Open
As nuclear and particle physics facilities move to higher intensities, the detectors used there must be more radiation tolerant. Diamond is in use at many facilities due to its inherent radiation tolerance and ease of use. In this article …
View article: CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways
CDX-585, a Bispecific Antibody with Dual Targeting of ILT4 and PD-1 Checkpoint Pathways Open
Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockad…
View article: Dual targeting of mast cells and TSLP with a bispecific antibody
Dual targeting of mast cells and TSLP with a bispecific antibody Open
Rationale Reduction of mast cells (MCs) through stem cell factor (SCF) neutralization combined with inhibition of the alarmin TSLP in a single molecule may result in broader efficacy in inflammatory disorders. Methods Monoclonal antibodies…
View article: Progress in Diamond Detectors
Progress in Diamond Detectors Open
Detectors based on Chemical Vapor Deposition (CVD) diamond have been used successfully in Luminosity and Beam Condition Monitors (BCM) in the highest radiation areas of the LHC. Future experiments at CERN will accumulate an order of magnit…
View article: Radiation tolerance of diamond detectors
Radiation tolerance of diamond detectors Open
Diamond is used as detector material in high energy physics experiments due to its inherent radiation tolerance. The RD42 collaboration has measured the radiation tolerance of chemical vapour deposition (CVD) diamond against proton, pion, …
View article: Anti‐KIT monoclonal antibody CDX‐0159 induces profound and durable mast cell suppression in a healthy volunteer study
Anti‐KIT monoclonal antibody CDX‐0159 induces profound and durable mast cell suppression in a healthy volunteer study Open
Background Mast cells (MC) are powerful inflammatory immune sentinel cells that drive numerous allergic, inflammatory, and pruritic disorders when activated. MC‐targeted therapies are approved in several disorders, yet many patients have l…
View article: 798 CDX-585, A bispecific antibody with dual targeting of ILT4 and PD-1 checkpoint pathways
798 CDX-585, A bispecific antibody with dual targeting of ILT4 and PD-1 checkpoint pathways Open
Background Activation of the ITIM-bearing ILT4/LILRB2 receptor by its cognate ligands (HLA-G and HLA Class I) has been postulated as a resistance mechanism for checkpoint blockade of PD-1 and CTLA-4. Dual inhibition of receptors that suppr…
View article: Sensitivity to millicharged particles in future proton-proton collisions at the LHC with the milliQan detector
Sensitivity to millicharged particles in future proton-proton collisions at the LHC with the milliQan detector Open
We report on the expected sensitivity of dedicated scintillator-based\ndetectors at the LHC for elementary particles with charges much smaller than\nthe electron charge. The dataset provided by a prototype scintillator-based\ndetector is u…
View article: A Study of the Radiation Tolerance of CVD Diamond to 70 MeV Protons, Fast Neutrons and 200 MeV Pions
A Study of the Radiation Tolerance of CVD Diamond to 70 MeV Protons, Fast Neutrons and 200 MeV Pions Open
We measured the radiation tolerance of commercially available diamonds grown by the Chemical Vapor Deposition process by measuring the charge created by a 120 GeV hadron beam in a 50 μm pitch strip detector fabricated on each diamond sampl…
View article: 550 An Axl-targeting monoclonal antibody that inhibits Axl activity and potently stimulates the innate immune response
550 An Axl-targeting monoclonal antibody that inhibits Axl activity and potently stimulates the innate immune response Open
Background Axl is a member of the TAM (Tyro3/Axl/MerTK) family of receptor tyrosine kinases and a negative regulator of innate immunity. Activation of Axl through its ligand Gas6 leads to suppression of myeloid cell activity, while its act…
View article: Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy
Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy Open
CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1 checkpoint axis on T cells. Combining a CD27 agonist antibody with PD-1/PD-L1 blockade has shown synergistic antitumor activity in preclinical models, …
View article: Beam test results of 3D pixel detectors constructed with poly-crystalline CVD diamond
Beam test results of 3D pixel detectors constructed with poly-crystalline CVD diamond Open
As a possible candidate for extremely radiation tolerant tracking devices we present a novel detector design - namely 3D detectors - based on poly-crystalline CVD diamond sensors with a pixel readout. The fabrication of recent 3D detectors…
View article: Latest Results on the Radiation Tolerance of Diamond Detectors
Latest Results on the Radiation Tolerance of Diamond Detectors Open
We have measured the radiation tolerance of chemical vapor deposition (CVD) diamond against protons and neutrons. The relative radiation damage constant of 24 GeV protons, 800 MeV protons, 70 MeV protons, and fast reactor neutrons is prese…
View article: Recent Results from Polycrystalline CVD Diamond Detectors
Recent Results from Polycrystalline CVD Diamond Detectors Open
Diamond is a material in use at many nuclear and high energy facilities due to its inherent radiation tolerance and ease of use. We have characterized detectors based on chemical vapor deposition (CVD) diamond before and after proton irrad…
View article: Latest Results on Radiation Tolerance of Diamond Detectors
Latest Results on Radiation Tolerance of Diamond Detectors Open
At present most experiments at the CERN Large Hadron Collider (LHC) are planning upgrades in the next 5-10 years for their innermost tracking layers as well as luminosity monitors to be able to take data as the luminosity increases and CER…
View article: A study of the radiation tolerance of poly-crystalline and single-crystalline CVD diamond to 800 MeV and 24 GeV protons
A study of the radiation tolerance of poly-crystalline and single-crystalline CVD diamond to 800 MeV and 24 GeV protons Open
We have measured the radiation tolerance of poly-crystalline and single-crystalline diamonds grown by the chemical vapor deposition (CVD) process by measuring the charge collected before and after irradiation in a 50 m pitch strip detector…
View article: Top-quark physics at the CLIC electron-positron linear collider
Top-quark physics at the CLIC electron-positron linear collider Open
© 2019, The Author(s). The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies s = 380 GeV, 1.5 TeV, and 3 TeV. Its ai…
View article: Results from the CBC3 readout ASIC for CMS 2S-modules
Results from the CBC3 readout ASIC for CMS 2S-modules Open
The CBC3 is the latest version of the CMS Binary Chip for readout of the outer radial region of the upgraded CMS Tracker at the High Luminosity LHC. This 254-channel, 130 nm CMOS ASIC is designed to be bump-bonded to a substrate to which s…
View article: CBC3: a CMS microstrip readout ASIC with logic for track-trigger modules at HL-LHC
CBC3: a CMS microstrip readout ASIC with logic for track-trigger modules at HL-LHC Open
The CBC3 is the latest version of the CMS Binary Chip ASIC for readout of the outer radial region of the upgraded CMS Tracker at HL-LHC. This 254-channel, 130nm CMOS ASIC is designed to be bump-bonded to a substrate to which sensors will b…
View article: Diamond detectors for high energy physics experiments
Diamond detectors for high energy physics experiments Open
Beam test results of the radiation tolerance study of chemical vapour deposition (CVD) diamond against different particle species and energies is presented. We also present beam test results on the independence of signal size on incident p…
View article: Diamond Detector Technology: Status and Perspectives
Diamond Detector Technology: Status and Perspectives Open
The planned upgrade of the LHC to the High-Luminosity-LHC will push the luminosity limits above the original design values. Since the current detectors will not be able to cope with this environment ATLAS and CMS are doing research to find…
View article: CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy
CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy Open
CD27, a member of the TNFR superfamily, is constitutively expressed in most T cells and plays crucial roles in T cell effector functions. The costimulation and antitumor activity of CD27 agonistic Abs have been well documented in mouse mod…