Christian Nasr
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View article: Thyroid eye disease: What’s the latest?
Thyroid eye disease: What’s the latest? Open
Thyroid eye disease (TED) is an inflammatory autoimmune condition now recognized as being associated not only with Graves hyperthyroidism but also with euthyroidism and hypothyroidism. A high index of suspicion is required to diagnose TED …
View article: Developing a Chitosan/polyvinyl alcohol hydrogel for gastro-retentive release of ranitidine and enhanced anti-ulcerative properties
Developing a Chitosan/polyvinyl alcohol hydrogel for gastro-retentive release of ranitidine and enhanced anti-ulcerative properties Open
View article: High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy
High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy Open
Background: The SENZA-PDN study evaluated high-frequency 10-kHz spinal cord stimulation (SCS) for the treatment of painful diabetic neuropathy (PDN). Over 24 months, 10-kHz SCS provided sustained pain relief and improved health-related qua…
View article: Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes
Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes Open
ClincalTrials.gov Identifier, NCT03228420.
View article: #1707035 Neoadjuvant Tyrosine Kinase Inhibitor Therapy Enables Surgery for Previously Unresectable 15cm Anaplastic Thyroid Cancer
#1707035 Neoadjuvant Tyrosine Kinase Inhibitor Therapy Enables Surgery for Previously Unresectable 15cm Anaplastic Thyroid Cancer Open
View article: 146 NEOADJUVANT SYSTEMIC THERAPY FOR “INOPERABLE” THYROID CANCERS: SURGICAL RESECTION STRATEGIES
146 NEOADJUVANT SYSTEMIC THERAPY FOR “INOPERABLE” THYROID CANCERS: SURGICAL RESECTION STRATEGIES Open
Background Limited treatment options exist for “inoperable” thyroid cancers. Neoadjuvant (NEO) use of systemic tyrosine kinase inhibitors (TKI) has been anecdotally reported. We aimed to evaluate whether NEO-TKI therapy facilitates surgica…
View article: #1707020 Severe Cushing’s Syndrome due to ACTH-producing Pheochromocytoma
#1707020 Severe Cushing’s Syndrome due to ACTH-producing Pheochromocytoma Open
View article: Abstract No. 267 Treatment of Painful Diabetic Neuropathy: 10-kHz Spinal Cord Stimulation Provides Durable Pain Relief and Sensory Function Improvements
Abstract No. 267 Treatment of Painful Diabetic Neuropathy: 10-kHz Spinal Cord Stimulation Provides Durable Pain Relief and Sensory Function Improvements Open
View article: Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial
Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial Open
View article: Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer Open
Objectives Tall cell variant (TCV) papillary thyroid cancer (PTC) is a subtype of PTC associated with aggressive tumor behavior, advanced stage, and higher rates of recurrence and mortality. The present study aimed to test an established d…
View article: Abstract #1399039: Treatment of Painful Diabetic Neuropathy: 10 kHz SCS Provides Durable Pain Relief and Sensory Improvements
Abstract #1399039: Treatment of Painful Diabetic Neuropathy: 10 kHz SCS Provides Durable Pain Relief and Sensory Improvements Open
View article: Association of Treatment Strategies and Tumor Characteristics With Overall Survival Among Patients With Anaplastic Thyroid Cancer
Association of Treatment Strategies and Tumor Characteristics With Overall Survival Among Patients With Anaplastic Thyroid Cancer Open
Importance Survival outcomes for anaplastic thyroid cancer (ATC), the most aggressive subtype of thyroid cancers, have remained poor. However, targeted therapies and immunotherapies present new opportunities for treatment of this disease. …
View article: Real-World Performance of the Afirma Genomic Sequencing Classifier (GSC)—A Meta-analysis
Real-World Performance of the Afirma Genomic Sequencing Classifier (GSC)—A Meta-analysis Open
Context The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91%, specificity (SP) of 68%, positive predictive value (PPV) of 47%, and negat…
View article: Risk Factors Associated With Recurrence and Death in Patients With Tall Cell Papillary Thyroid Cancer
Risk Factors Associated With Recurrence and Death in Patients With Tall Cell Papillary Thyroid Cancer Open
Importance Tall cell morphology (TCM) is a rare and aggressive variant of papillary thyroid carcinoma (PTC) that has been associated with poor outcomes; however, the risk factors for worse survival are not well characterized. Objective To …
View article: LBSAT255 Real World Performance Of The Afirma Genomic Sequencing Classifier (GSC) - A Meta-analysis
LBSAT255 Real World Performance Of The Afirma Genomic Sequencing Classifier (GSC) - A Meta-analysis Open
The Afirma GSC aids in the clinical decision making for patients with indeterminate thyroid nodule cytology (ITN). The 2018 GSC validation study was a prospective, multi-center study, conducted on a patient cohort with ITN. All patients un…
View article: High-Frequency 10-kHz Spinal Cord Stimulation Improves Health-Related Quality of Life in Patients With Refractory Painful Diabetic Neuropathy: 12-Month Results From a Randomized Controlled Trial
High-Frequency 10-kHz Spinal Cord Stimulation Improves Health-Related Quality of Life in Patients With Refractory Painful Diabetic Neuropathy: 12-Month Results From a Randomized Controlled Trial Open
View article: Hürthle cell‐predominant thyroid fine needle aspiration cytology: A four risk‐factor model highly accurate in excluding malignancy and predicting neoplasm
Hürthle cell‐predominant thyroid fine needle aspiration cytology: A four risk‐factor model highly accurate in excluding malignancy and predicting neoplasm Open
Background Interpretation of Hürthle cell‐predominant cytologies (HCP) is very challenging as a majority is diagnosed as indeterminate. Prior studies have reported various cytologic features to help distinguish non‐neoplastic (NN) from neo…
View article: Poorly Differentiated Thyroid Carcinoma: Single Institution Series of Outcomes
Poorly Differentiated Thyroid Carcinoma: Single Institution Series of Outcomes Open
Advanced T and N stage were factors associated with significantly inferior outcomes. While select patients benefited with systemic treatment, it remains unclear if intensified locoregional therapy should be considered in patients with PDTC.
View article: Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial
Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial Open
View article: EPV144/#76 The Tunisian country-specific guidelines for endometrial cancer
EPV144/#76 The Tunisian country-specific guidelines for endometrial cancer Open
Objectives Endometrial cancer is the second gynecologic cancer. The varying tumors profile from country to country and the difference in the means available in each country have raised the need for a country-specific guideline. We aim to P…
View article: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy Open
ClincalTrials.gov Identifier: NCT03228420.
View article: Pleural effusion as a novel prognostic factor in metastatic thyroid carcinoma
Pleural effusion as a novel prognostic factor in metastatic thyroid carcinoma Open
Objective: To identify novel prognostic risk factors and compare them with other known prognostic risk factors in follicular-cell-derived thyroid carcinoma (FDTC) with distant metastases. Methods: A retrospective review was conducted of ad…
View article: The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample Open
Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier a…
View article: High-frequency spinal cord stimulation at 10 kHz for the treatment of painful diabetic neuropathy: design of a multicenter, randomized controlled trial (SENZA-PDN)
High-frequency spinal cord stimulation at 10 kHz for the treatment of painful diabetic neuropathy: design of a multicenter, randomized controlled trial (SENZA-PDN) Open
Background Painful diabetic neuropathy (PDN), a debilitating and progressive chronic pain condition that significantly impacts quality of life, is one of the common complications seen with long-standing diabetes mellitus. Neither pharmacol…
View article: Real-world Comparison of Afirma GEC and GSC for the Assessment of Cytologically Indeterminate Thyroid Nodules
Real-world Comparison of Afirma GEC and GSC for the Assessment of Cytologically Indeterminate Thyroid Nodules Open
Context Molecular tests have improved the accuracy of preoperative diagnosis of indeterminate thyroid nodules. The Afirma Gene Sequencing Classifier (GSC) was developed to improve the specificity of the Gene Expression Classifier (GEC). In…
View article: Factors Associated with Recurrence and Death in Patients with Aggressive Tall Cell Papillary Thyroid Cancer: A Large, Single Institution Series
Factors Associated with Recurrence and Death in Patients with Aggressive Tall Cell Papillary Thyroid Cancer: A Large, Single Institution Series Open
View article: Molecular Variants and Their Risks for Malignancy in Cytologically Indeterminate Thyroid Nodules
Molecular Variants and Their Risks for Malignancy in Cytologically Indeterminate Thyroid Nodules Open
Background: Gene panels are routinely used to assess predisposition to hereditary cancers by simultaneously testing multiple susceptibility genes and/or variants. More recently, genetic panels have been implemented as part of…
View article: MON-609 Hormonal Outcomes after Partial Thyroidectomy: The Cleveland Clinic Experience
MON-609 Hormonal Outcomes after Partial Thyroidectomy: The Cleveland Clinic Experience Open
Background: Partial thyroidectomies (PT) are done frequently, yet controversy remains about thyroid hormonal outcomes. A large number of patients are also being started on thyroid hormone replacement (THR) immediately post PT. In this stud…
View article: Subclinical hypothyroidism: When to treat
Subclinical hypothyroidism: When to treat Open
Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T4) level. Whether it should be treated remains controversial. Currently, the best practical …
View article: Pseudohyponatremia in the Setting of Hypercholesterolemia
Pseudohyponatremia in the Setting of Hypercholesterolemia Open