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View article: Chemical composition and biological effects of Lavandula angustifolia Mill., essential oils
Chemical composition and biological effects of Lavandula angustifolia Mill., essential oils Open
View article: Biological activities of Centaurium erythraea and its main chemotypes: menthol, carvacrol, and tricosane
Biological activities of Centaurium erythraea and its main chemotypes: menthol, carvacrol, and tricosane Open
View article: Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols
Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols Open
View article: Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights Open
View article: Expediting multiple biological properties of main bioactive compounds of Mentha pulegium L
Expediting multiple biological properties of main bioactive compounds of Mentha pulegium L Open
View article: The First Report on Chemical Composition, Antioxidant, Antienzymatic, Antibacterial, and Anticandidal Properties of <i>Teucrium gypsophilum</i> Essential Oils
The First Report on Chemical Composition, Antioxidant, Antienzymatic, Antibacterial, and Anticandidal Properties of <i>Teucrium gypsophilum</i> Essential Oils Open
Teucrium gypsophilum is an endemic species of the Rif‐Moroccan region, known for its traditional medicinal uses. The main objective of this research is, for the first time, to characterize the volatile compounds and evaluate the antioxidan…
View article: Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches
Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches Open
View article: The role of inflammation in colorectal Cancer and the preventive potential of natural compounds
The role of inflammation in colorectal Cancer and the preventive potential of natural compounds Open
Colorectal cancer (CRC) is the second most deadly cancer and the third most common in the world. The risk of developing CRC is well understood to be increased by chronic inflammation, which activates signaling pathways promoting its progre…
View article: Unlocking the natural chemical sources, nutritional properties, biological effects, and molecular actions of Ajoene
Unlocking the natural chemical sources, nutritional properties, biological effects, and molecular actions of Ajoene Open
Ajoene, a bioactive sulfur-containing compound derived from garlic, exhibits a wide range of pharmacological properties that have garnered substantial scientific interest. This review presents a comprehensive analysis of its biological act…
View article: Clinical efficacy and mechanistic insights of FDA-approved HDAC inhibitors in the treatment of lymphoma
Clinical efficacy and mechanistic insights of FDA-approved HDAC inhibitors in the treatment of lymphoma Open
Lymphomas are complex malignancies of blood cells, characterized by the malignant transformation of lymphocytes. This transformation is partially driven by disruptions in epigenetic regulation, particularly the acetylation of histones. Amo…
View article: Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights
Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights Open
Diabetes mellitus (DM) is a prevalent, long-term illness that adversely impacts patients' quality of life and significantly increases the risk of severe complications. Type 2 diabetes mellitus (T2DM) accounts for approximately 90 % of glob…
View article: DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer
DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer Open
DNA methylation is an epigenetic mark involving the addition of a methyl group to DNA, particularly at cytosine residues. This methylation plays an important role in regulating gene expression through direct gene repression or through the …
View article: Recent advances and molecular mechanisms of TGF-β signaling in colorectal cancer, with focus on bioactive compounds targeting
Recent advances and molecular mechanisms of TGF-β signaling in colorectal cancer, with focus on bioactive compounds targeting Open
Colorectal cancer (CRC) is one of the most significant forms of human cancer. It is characterized by its heterogeneity because several molecular factors are involved in contiguity and can link it to others without having a linear correlati…
View article: Stochasticity of anticancer mechanisms underlying clinical effectiveness of vorinostat
Stochasticity of anticancer mechanisms underlying clinical effectiveness of vorinostat Open
The Food and Drug Administration (FDA) has approved vorinostat, also called Zolinza®, for its effectiveness in fighting cancer. This drug is a suberoyl-anilide hydroxamic acid belonging to the class of histone deacetylase inhibitors (HDACi…
View article: Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases Open
View article: Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus
Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus Open
View article: Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress
Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress Open
Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately l…
View article: Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review
Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review Open
Cannabinol (CBN) is a non-psychoactive phytocannabinoid found in Cannabis sativa. Although overshadowed by its more well-known counterparts, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), CBN has been gaining attention d…
View article: Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies
Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies Open
The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibi…
View article: Cutaneous Leishmaniasis: Physiopathology, Molecular Diagnostic, and Therapeutic Approaches
Cutaneous Leishmaniasis: Physiopathology, Molecular Diagnostic, and Therapeutic Approaches Open
This in-depth study explores various aspects of cutaneous leishmaniasis, shedding light on the physiopathology of the infection, advances in molecular diagnostic techniques, and therapeutic approaches currently in development. Our investig…
View article: Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights
Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights Open
Cyanobacteria and microalgae contain various phytochemicals, including bioactive components in the form of secondary metabolites, namely flavonoids, phenolic acids, terpenoids, and tannins, with remarkable anticancer effects. This review h…
View article: Phytosterols activating nuclear receptors are involving in steroid hormone-dependent cancers: Myth or fact?
Phytosterols activating nuclear receptors are involving in steroid hormone-dependent cancers: Myth or fact? Open
Nuclear receptors (NRs) represent intracellular proteins that function as a signaling network of transcriptional factors to control genes in response to a variety of environmental, dietary, and hormonal stimulations or serve as orphan rece…
View article: Fenchone and camphor: Main natural compounds from Lavandula stoechas L., expediting multiple in vitro biological activities
Fenchone and camphor: Main natural compounds from Lavandula stoechas L., expediting multiple in vitro biological activities Open
Lavandula stoechas, a Mediterranean plant, renowned in traditional medicine for its health benefits, is also arousing strong interest associated with its essential oils (EOs) with promising therapeutic properties. The aim of this st…
View article: Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils
Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils Open
Background: Screening new natural molecules with pharmacological and/or cosmetic properties remains a highly sought-after area of research. Moreover, essential oils and volatile compounds have recently garnered significant interest as natu…
View article: Anticancer clinical efficiency and stochastic mechanisms of belinostat
Anticancer clinical efficiency and stochastic mechanisms of belinostat Open
Cancer progression is strongly affected by epigenetic events in addition to genetic modifications. One of the key elements in the epigenetic control of gene expression is histone modification through acetylation, which is regulated by the …
View article: Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin
Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin Open
Romidepsin, also known as NSC630176, FR901228, FK-228, FR-901228, depsipeptide, or Istodax®, is a natural molecule produced by the Chromobacterium violaceum bacterium that has been approved for its anti-cancer effect. This compound is a se…
View article: Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and induction of cellular cell death related to cellular stresses
Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and induction of cellular cell death related to cellular stresses Open
View article: Natural sources, biological effects, and pharmacological properties of cynaroside
Natural sources, biological effects, and pharmacological properties of cynaroside Open
Cynaroside is a flavonoid, isolated from several species belonging to the Apiaceae, Poaceae, Lamiaceae, Solanaceae, Zingiberaceae, Compositae and other families and it can be extracted from seeds, roots, stems, leaves, barks, flowers, frui…
View article: Traditional use, phytochemistry, toxicology, and pharmacological properties of Lavandula dentata L.: A comprehensive review
Traditional use, phytochemistry, toxicology, and pharmacological properties of Lavandula dentata L.: A comprehensive review Open
Lavandula dentata L. is a medicinal plant belonging to the Lamiaceae family, frequently used in traditional medicine to treat various pathologies such as diabetes, inflammation, microbial infections, and other disordors. The present work a…
View article: Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L.
Determination of Chemical Composition and Investigation of Biological Activities of Ocimum basilicum L. Open
This study aimed to determine the chemical composition of the essential oils (EOs) of Ocimum basilicum L., as well as to evaluate the antibacterial, antidiabetic, dermatoprotective, and anti-inflammatory properties, and the EOs and aqueous…