Abedelnasser Abulrob
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View article: Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease
Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease Open
Efficient delivery of therapeutics to the central nervous system (CNS) remains a major challenge for the treatment of neurological diseases. Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinu…
View article: Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity Open
The identification of molecular biomarkers in CSF from individuals affected by Huntington disease may help improve predictions of disease onset, better define disease progression and could facilitate the evaluation of potential therapies. …
View article: Molecular and Functional Characterization of Caveolae in Mixed Cultures of Human NT-2 Neurons and Astrocytes
Molecular and Functional Characterization of Caveolae in Mixed Cultures of Human NT-2 Neurons and Astrocytes Open
Caveolae are plasma membrane invaginations that are enriched in cholesterol-binding proteins called caveolins. The presence of caveolae and caveolins in mixed cultures of human neurons and glia has not been investigated. Here, we sought to…
View article: Antisense oligonucleotides: absorption, distribution, metabolism, and excretion
Antisense oligonucleotides: absorption, distribution, metabolism, and excretion Open
2'-MOE, 2'-O-methoxyethyl; 2'PS, 2 modified PS; ADME, absorption, distribution, metabolism, and excretion; ASO, antisense oligonucleotide; AUC, area under the curve; BNA, bridged nucleic acid; CPP, cell-penetrating peptide; CMV, cytomegalo…
View article: P685In vivo near-infrared fluorescence (NIRF) molecular imaging of atherosclerosis
P685In vivo near-infrared fluorescence (NIRF) molecular imaging of atherosclerosis Open
Atherosclerosis 135high density lipoprotein-cholesterol (HDL-C), probably due to statin use (79 vs. 0%).Furthermore, FABP4 levels of serum and primary endothelial progenitor cell (EPC) culture supernatant from CAD patients were higher than…
View article: Atherosclerosis and Vascular Imaging 2016
Atherosclerosis and Vascular Imaging 2016 Open
Cardiovascular disease is the main cause of death in the West, and vascular disease is the most common cardiovascular clinical problem. The disease results in serious morbidity and mortality, and carries economic cost implications. While c…
View article: Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy
Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy Open
Atherosclerotic cardiovascular diseases are characterized by the formation of a plaque in the arterial wall. Intravascular ultrasound (IVUS) provides high-resolution images allowing delineation of atherosclerotic plaques. When combined wit…