Nassir Mokarram
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View article: EXTH-95. <i>In vivo</i> electrotaxis of glioblastoma in a rodent model
EXTH-95. <i>In vivo</i> electrotaxis of glioblastoma in a rodent model Open
The treatment of glioblastoma (GBM) continues to be a major clinical challenge, in great part due to the diffusely invasive nature of tumor spread, including into the eloquent regions of the brain. This limits complete surgical resection, …
View article: TIP-27. An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients
TIP-27. An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients Open
BACKGROUND The TMD is a surgically implanted catheter system that remains in place after tumor resection. The TMD is not used to deliver therapy but serves as a platform to monitor changes in the tumor environment post-treatment, potential…
View article: Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma
Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma Open
View article: A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma
A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma Open
Background A major hurdle to effectively treating glioblastoma (GBM) patients is the lack of longitudinal information about tumor progression, evolution, and treatment response. Methods In this study, we report the use of a neural tract-in…
View article: Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats
Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats Open
Traumatic brain injury (TBI) by an external physical impact results in compromised brain function via undesired neuronal death. Following the injury, resident and peripheral immune cells, astrocytes, and neural stem cells (NSCs) cooperativ…
View article: Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats
Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats Open
Traumatic Brain Injury (TBI) by an external physical impact results in compromised brain function via undesired neuronal death. Following the injury, resident and peripheral immune cells, astrocytes, and neural stem cells (NSCs) cooperativ…
View article: Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates
Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates Open
Treatment of neuroepithelial cancers remains a daunting clinical challenge, particularly due to an inability to address rampant invasion deep into eloquent regions of the brain. Given the lack of access, and the dispersed nature of brain t…
View article: Immunoengineering nerve repair
Immunoengineering nerve repair Open
Significance Annually, more than 250,000 Americans suffer from a peripheral nerve injury, which results in a loss of function and a compromised quality of life. The current clinical gold standard to bridge long, nonhealing nerve gaps, the …
View article: Engineering challenges for brain tumor immunotherapy
Engineering challenges for brain tumor immunotherapy Open
Malignant brain tumors represent one of the most devastating forms of cancer with abject survival rates that have not changed in the past 60years. This is partly because the brain is a critical organ, and poses unique anatomical, physiolog…
View article: Bacterial Carriers for Glioblastoma Therapy
Bacterial Carriers for Glioblastoma Therapy Open
View article: Preferential recruitment of anti-inflammatory monocytes significantly enhances peripheral nerve regeneration
Preferential recruitment of anti-inflammatory monocytes significantly enhances peripheral nerve regeneration Open
Event Abstract Back to Event Preferential recruitment of anti-inflammatory monocytes significantly enhances peripheral nerve regeneration Nassir Mokarram1, Kyle Dymanus1, Akhil Srinivasan1, Arthur English2 and Ravi Bellamkonda1 1 Georgia T…
View article: Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes
Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes Open