Natacha Omer
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View article: The Use of a Ward Round Teaching Tool in a Paediatric Oncology Department.
The Use of a Ward Round Teaching Tool in a Paediatric Oncology Department. Open
We demonstrate enhanced teaching despite poor perceived uptake, demonstrating the potential of the STIC framework with further implementation. Our study also highlights that in addition to a specific teaching focus, consultant engagement a…
View article: A systematic review on the impact of delayed local therapy in patients with Ewing sarcoma of the pelvis
A systematic review on the impact of delayed local therapy in patients with Ewing sarcoma of the pelvis Open
Background Local treatment of pelvic Ewing Sarcoma (EWS) is czhallenging due to complex anatomy and potential complications. Local therapy may be deferred to maintain chemotherapy dose-intensity, but the impact of this delay on outcomes re…
View article: Expanding the utility of transcriptome analysis for mutation detection in high-risk childhood precision oncology
Expanding the utility of transcriptome analysis for mutation detection in high-risk childhood precision oncology Open
In precision oncology, whole transcriptome sequencing (RNA-seq) excels at identifying oncogenic fusions. Here, using a cohort of 477 high-risk paediatric tumours, we demonstrate that RNA-seq can identify all mutation classes found previous…
View article: Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR
Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR Open
Background Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer‐related morbidity and mortality in children and young adults. These cance…
View article: Precision-guided treatment in high-risk pediatric cancers
Precision-guided treatment in high-risk pediatric cancers Open
View article: TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer
TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer Open
View article: High-dose chemotherapy for Ewing sarcoma and Rhabdomyosarcoma: A systematic review by the Australia and New Zealand sarcoma association clinical practice guidelines working party
High-dose chemotherapy for Ewing sarcoma and Rhabdomyosarcoma: A systematic review by the Australia and New Zealand sarcoma association clinical practice guidelines working party Open
Prospective randomised trials are required to determine the utility of HDT/ASCT in ES and RMS. Selected patients with relapsed ES could be considered for HDT/ASCT.
View article: Precision-guided treatment improves outcomes for children with high-risk cancers
Precision-guided treatment improves outcomes for children with high-risk cancers Open
Recent reports have shown that precision medicine can identify new treatment strategies for childhood cancer patients. However, it remains unclear which patients will benefit most from precision-guided treatment (PGT). Here we report 384 c…
View article: A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer Open
View article: A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer Open
Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refi…
View article: Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors
Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors Open
Despite aggressive surgery, chemotherapy, and radiotherapy, survival of children and adolescents and young adults (AYAs) with sarcoma has not improved significantly in the past four decades. Immune checkpoint inhibitors (ICIs) are an excit…
View article: Enhancing Natural Killer Cell Targeting of Pediatric Sarcoma
Enhancing Natural Killer Cell Targeting of Pediatric Sarcoma Open
Osteosarcoma, Ewing sarcoma (EWS), and rhabdomyosarcoma (RMS) are the most common pediatric sarcomas. Conventional therapy for these sarcomas comprises neoadjuvant and adjuvant chemotherapy, surgical resection of the primary tumor and/or r…
View article: Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma
Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma Open
Sarcomas are a diverse group of bone and soft tissue tumors that account for over 10% of childhood cancers. Outcomes are particularly poor for children with refractory, relapsed, or metastatic disease. Chimeric antigen receptor T (CAR T) c…
View article: DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM
DIPG-75. PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM Open
The Australian Zero Childhood Cancer (ZERO) program aims to assess the feasibility of a comprehensive precision medicine approach to improve outcomes for patients with an expected survival <30%. ZERO combines molecular profiling (whole …