Natalia Chira
YOU?
Author Swipe
View article: Dystrophin Dp71 is essential for the development and function of macrophages
Dystrophin Dp71 is essential for the development and function of macrophages Open
Mutations in the DMD gene, encoding dystrophins, cause progressive muscle degeneration with severe sterile inflammation. While macrophages predominate amongst muscle-infiltrating cells, being central to both damage and regeneration, they w…
View article: P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles
P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles Open
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic m…
View article: Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns
Total Absence of Dystrophin Expression Exacerbates Ectopic Myofiber Calcification and Fibrosis and Alters Macrophage Infiltration Patterns Open
Duchenne muscular dystrophy (DMD) causes severe disability and death of young men because of progressive muscle degeneration aggravated by sterile inflammation. DMD is also associated with cognitive and bone-function impairments. This comp…
View article: Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism Open
View article: Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition
Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition Open
P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular adenosine triphosphate (ATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational d…